Whole-body diffusion-weighted MRI and 18F-FDG PET/CT can discriminate between different lymphoma subtypes

Correlation between glycolytic activity on [18F]‐FDG‐PET and cell density on diffusion‐weighted MRI in lymphoma at staging

“…Findings suggestive of the latter were observed in several types of tumor, such as breast cancer, head and neck squamous cell carcinoma, and primary rectal cancer . In lymphomas, there is an additional, strong heterogeneity in NHL due to the considerable number of histological subtypes, which further increases the tumor tissue heterogeneity between patients, adds to the biological complexity, and may be chiefly responsible for the variability detected in our study, as well as in previous studies …”

“…[8][9][10][11][12] In lymphomas, there is an additional, strong heterogeneity in NHL due to the considerable number of histological subtypes, [33][34][35][36] which further increases the tumor tissue heterogeneity between patients, adds to the biological complexity, and may be chiefly responsible for the variability detected in our study, as well as in previous studies. 3,15,16,19,25,37 Moreover, the quantitative ADC and SUV data are also influenced by several technical factors, such as the selection of the b-values, acquisition technique (EPI-SPAIR or STIR-based; free-breathing, breath-hold, or respiratory triggered), and the presence of artifacts for DWI. These data are also influenced by the postinjection delay, reconstruction parameters (numbers of iteration and subsets), and reconstruction algorithms for PET; and finally, for both techniques, by the size and placement of the regions of interest.…”

Whole‐body magnetic resonance imaging (WB‐MRI) in lymphoma: State of the art

“…Of note, Mosavi et al evaluated 50 patients with lymphoma (12 HLs, 29 aggressive lymphomas, and nine i‐NHLs) by WB‐MRI and reported significantly lower ADC values in i‐NHLs than in other lymphomas. This suggests the potential application of WB‐MRI to detect the transformation of i‐NHLs in aggressive NHL . As previously mentioned, both 18 F‐FDG‐PET/CT and WB‐MRI have shown to be valid tools to detect BMI in aggressive lymphomas.…”

PET Scan in Hodgkin Lymphoma

“…There is preliminary evidence that the glycolytic rate as measured by FDG-PET and changes in water compartmentalization and water diffusion as measured by the apparent diffusion coefficients on DWI (ADC) are independent biological phenomena in newly diagnosed DLBCL [173,174]. ADC values were also found to discriminate between indolent and aggressive NHL, and this finding can be useful in assessing possible transformation from indolent to aggressive NHL [176]. Thus, these data did not support the replacement of FDG-PET with DW-MRI for response evaluation in lymphoma patients [175].…”