No changes in event-related potentials with estrogen or estrogen plus progesterone treatment in healthy older hysterectomized women: results from a double-blind, placebo-controlled study

Walpurger, Verena; Pietrowsky, Reinhard; Djahansouzi, S.; Wolf, Oliver T.

doi:10.1007/s00213-004-2090-5

Cited by 5 publications

(3 citation statements)

References 42 publications

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“…Another randomized clinical trial of 20 weeks duration, in women aged 70 and older (N=115), using a standard dose (2 mg) of estradiol, showed no benefit of hormone on cognitive function 26 . This was consistent with the results of another study that did not find any change in event‐related potentials or electrophysiological indicators of cognitive information processing after treatment with standard‐dose estradiol 27 …”

Section: Discussionsupporting

confidence: 74%

The Effect of 3‐Year Treatment with 0.25 mg/day of Micronized 17β‐Estradiol on Cognitive Function in Older Postmenopausal Women

Pefanco

Kenny

Kaplan

et al. 2007

J American Geriatrics Society

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Section: Discussionsupporting

confidence: 74%

The Effect of 3‐Year Treatment with 0.25 mg/day of Micronized 17β‐Estradiol on Cognitive Function in Older Postmenopausal Women

Pefanco

Kenny

Kaplan

et al. 2007

J American Geriatrics Society

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“…31 Finally, the most recent RCT assessed 33 older hysterectomized women using a number of cognitive tests and electrophysiological indicators and also found no significant effect of estradiol. 19 However, specific results relating to the cognitive outcome measures were not reported. These RCTs share many problems, including the significant issue of including older women who may or may not have previously received HT as participants.…”

Section: Rctsmentioning

confidence: 98%

Is cognitive functioning detrimentally affected after early, induced menopause?

Vearncombe

Pachana

2009

Menopause

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Although smaller prospective studies have found that surgical menopause is associated with specific deficits in the memory (visual and verbal) and verbal fluency domains, larger randomized, controlled trials have generally found no effect of surgical menopause on cognitive functioning. The effects of chemical menopause are harder to assess as only three prospective trials have explicitly investigated the effect of induced menopause in the context of breast cancer treatment, and the results remain inconclusive. However, as surgical and chemical menopause both comprise the abrupt withdrawal of estrogen, there is the potential that this process may exert neurobiological effects that are different from those occurring with natural menopause and further prospective investigations comprising pre- and postsurgical/chemotherapy neuropsychological assessments are warranted.

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“…Several outcome measures were taken (e.g. cognitive tests and EEG measures, which will be reported elsewhere [23,24] . The most important inclusion and exclusion criteria were screened via phone: hysterectomy; no estrogen treatment within the past 12 months; absence of cancers, tumors, deep vein thrombosis, metabolic diseases, cardiovascular diseases and neurological or psychiatric disorders.…”

Section: Recruitment and Telephone Screeningmentioning

confidence: 99%

Investigating the Effects of Estradiol or Estradiol/Progesterone Treatment on Mood, Depressive Symptoms, Menopausal Symptoms and Subjective Sleep Quality in Older Healthy Hysterectomized Women: A Questionnaire Study

Heinrich¹,

Wolf²

2005

Neuropsychobiology

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Clinical studies have documented that estrogen treatment often ameliorates mood disturbances and depressive symptoms occurring during the menopausal transition. The relevance of gonadal hormones for mood and well-being in healthy older nondepressed women is less well understood. Fifty-one healthy hysterectomized women (mean age 64) participated in a placebo-controlled double-blind study on the effects of gonadal hormones on cognition. They received either estradiol (2 mg estradiol valerate), estradiol plus progesterone (100 mg micronized progesterone) or placebo. Mood, well being, menopausal symptoms, depressive symptoms and subjective sleep quality were measured at baseline and after 4 and 24 weeks of treatment using three questionnaires. Thirty-five women could be included into the final analysis. Strong increases in estradiol and progesterone levels occurred in response to the treatment. The two hormones, however, had no effects on mood, well-being, menopausal symptoms, sleep quality and depressive symptoms. The current small study suggests that older healthy nondepressed hysterectomized women do not react with positive or negative mood changes to estradiol or estradiol/progesterone treatment.

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No changes in event-related potentials with estrogen or estrogen plus progesterone treatment in healthy older hysterectomized women: results from a double-blind, placebo-controlled study

Abstract: Estradiol or estradiol/progesterone treatment appears to have no strong effects on several ERP markers of information processing in older hysterectomized women. The current negative findings might suggest a reduced sensitivity of the aged brain to gonadal steroids.

Cited by 5 publications

References 42 publications

The Effect of 3‐Year Treatment with 0.25 mg/day of Micronized 17β‐Estradiol on Cognitive Function in Older Postmenopausal Women

The Effect of 3‐Year Treatment with 0.25 mg/day of Micronized 17β‐Estradiol on Cognitive Function in Older Postmenopausal Women

Is cognitive functioning detrimentally affected after early, induced menopause?

Investigating the Effects of Estradiol or Estradiol/Progesterone Treatment on Mood, Depressive Symptoms, Menopausal Symptoms and Subjective Sleep Quality in Older Healthy Hysterectomized Women: A Questionnaire Study

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