Is cognitive functioning detrimentally affected after early, induced menopause?

Vearncombe, Katharine; Pachana, Nancy A.

doi:10.1097/gme.0b013e3181775eb4

Cited by 45 publications

(31 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These results are consistent with improved memory in mice given other replacement estrogens treatments [52]. Over half of randomized clinical studies find significant improvements in cognition and attention after estrogen replacement therapy (Table 1) [53]. Estradiol has been shown to increase levels of ApoE in the brain, proposed to be beneficial for neuronal reorganization and repair [7].…”

Section: Estradiolsupporting

confidence: 72%

The Confounding Factor of Apolipoprotein E on Response to Chemotherapy and Hormone Regulation Altering Long-Term Cognition Outcomes

Acevedo¹

2012

Lipoproteins - Role in Health and Diseases

View full text Add to dashboard Cite

Section: Estradiolsupporting

confidence: 72%

The Confounding Factor of Apolipoprotein E on Response to Chemotherapy and Hormone Regulation Altering Long-Term Cognition Outcomes

Acevedo¹

2012

Lipoproteins - Role in Health and Diseases

View full text Add to dashboard Cite

“…The results also showed that . However, it was found no effect of surgical menopause on cognitive functioning 3 . Estrogen replacement therapy has been reported to prevent or delay cognitive decline in postmenopausal women and in estrogen-depleted animals 3,4 .…”

Section: Discussionmentioning

confidence: 99%

“…It has been suggested that estrogen may prevent cognitive impairments due to aging 2 . Increasing in the risk of Alzheimer's disease due to estrogen deficiency has been reported 3 . It was also found that estrogens have enhancing action on memory tasks 4 .…”

Section: Brain Tissue Oxidative Damage As a Possible Mechanism For Thmentioning

confidence: 99%

Brain tissue oxidative damage as a possible mechanism for the deleterious effect of a chronic high dose of estradiol on learning and memory in ovariectomized rats

Khodabandehloo

Hosseini

Rajaei

et al. 2013

Arq. Neuro-Psiquiatr.

View full text Add to dashboard Cite

In addition to antioxidative effects, estrogens also exert pro-oxidative actions. The effect of chronic administration of a high dose of estradiol valerate on Morris water maze tasks and brain tissues oxidative damage was investigated. The Sham-Est and OVX-Est groups were treated with estradiol valerate (4 mg/kg) for 12 weeks. Escape latency and traveled path in the Sham-Est and OVX-Est groups were significantly higher than in the Sham and OVX groups (p<0.01 and p<0.001). In the probe trial, the animals of the Sham-Est and OVX-Est groups spent lower time in Q 1 compared to Sham and OVX groups (p<0.05 and p<0.001). In Sham-Est and OVX-Est groups, the brain tissue total thiol concentration was significantly lower, and malondialdehyde (MDA) concentrations were higher than in the Sham and OVX groups (p<0.05 and p<0.001). It is concluded that administration of high exogenous levels of estradiol impairs performance and enhances oxidative stress.Key words: learning, memory, ovariectomy, estradiol, morris water maze, oxidative stress. RESUMOAlém dos efeitos antioxidantes, os estrógenos também têm ação pró-oxidativa. Foi investigado o efeito da administração crônica de alta dose de valereato de estradiol no desempenho do labirinto aquático de Morris e o dano oxidativo ao tecido cerebral. Os grupos Sham-Est e OVX-Est foram tratados com valereato de estradiol (4 mg/kg) por 12 semanas. O tempo de latência para escapada e o caminho percorrido foram significativamente maiores nos grupos Sham-Est e OVX-Est em relação aos grupos Sham e OVX (p<0,01 e p<0,001). No estudo probe, os animais dos grupos Sham-Est e OVX-Est levaram menos tempo no Q 1 em comparação aos grupos Sham e OVX (p<0,05 e p<0,001). Nos grupos Sham-Est e OVX-Est, a concentração total de tiol foi significativamente menor, enquanto a concentração de malondialdehydo (MDA) for maior do que aquela dos grupos Sham e OVX (p<0,05 e p<0,001). Concluiu-se que a administração de altas doses de estradiol exógeno compromete o desempenho e aumenta o estresse oxidativo naqueles animais.Palavras-Chave: aprendizado, memória, ovariectomia, estradiol, Labirinto Aquático de Morris, estresse oxidativo.

show abstract

“…An earlier age at menopause, 5,6 particularly surgical menopause, [7][8][9] has been associated with increased risk of dementia and cognitive decline in some but not all 10,11 studies. [12][13][14] In general, prior studies of surgical menopause examined the risk of developing Alzheimer disease (AD) or dementia but did not assess intermediate phenotypes, such as change in performance on detailed cognitive testing or development of the neuropathologic features associated with AD.…”

mentioning

confidence: 99%

Age at surgical menopause influences cognitive decline and Alzheimer pathology in older women

et al. 2014

View full text Add to dashboard Cite

Objective: To determine the association between age at surgical menopause and both cognitive decline and Alzheimer disease (AD) pathology in 2 longitudinal cohorts.Methods: Female subjects from 2 longitudinal studies of cognitive decline (Religious Orders Study and Rush Memory and Aging Project) were included (total n 5 1,884). The primary analysis examined the association between age at surgical menopause and decline in a global cognition score. Secondary analyses examined additional outcomes: 1) decline in 5 cognitive subdomains and 2) a global measure of the burden of AD pathology. In exploratory analyses, we examined the effect of hormone replacement therapy (HRT). We adjusted all models for age, education, smoking, and cohort and stratified by surgical vs natural menopause.Results: For the 32% of subjects with surgical menopause, earlier age at menopause was associated with faster decline in global cognition (p 5 0.0007), specifically episodic memory (p 5 0.0003) and semantic memory (p 5 0.002). Earlier age at menopause was also associated with increased AD neuropathology (p 5 0.038), in particular neuritic plaques (p 5 0.013). HRT use for at least 10 years, when administered within a 5-year perimenopausal window, was associated with decreased decline in global cognition. No associations were seen in women who had natural menopause.Conclusions: Early age at surgical menopause was associated with cognitive decline and AD neuropathology. Ongoing studies should clarify the potential effect of HRT on this relationship.

show abstract

Is cognitive functioning detrimentally affected after early, induced menopause?

Cited by 45 publications

References 50 publications

The Confounding Factor of Apolipoprotein E on Response to Chemotherapy and Hormone Regulation Altering Long-Term Cognition Outcomes

The Confounding Factor of Apolipoprotein E on Response to Chemotherapy and Hormone Regulation Altering Long-Term Cognition Outcomes

Brain tissue oxidative damage as a possible mechanism for the deleterious effect of a chronic high dose of estradiol on learning and memory in ovariectomized rats

Age at surgical menopause influences cognitive decline and Alzheimer pathology in older women

Contact Info

Product

Resources

About