No change of serum levels of leptin and adiponectin during anti-tumour necrosis factor antibody treatment with adalimumab in patients with rheumatoid arthritis

Härle, Peter; Sarzi-Puttini, Piercarlo; Cutolo, Maurizio; Straub, Rainer H.

doi:10.1136/ard.2005.040857

Cited by 66 publications

(51 citation statements)

References 11 publications

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“…Recent reports in literature demonstrate, that anti-TNF treatment was associated with an increase [8,22,28,39] or no change in adiponectin levels [40]. The adiponectin levels were positively correlated with the endothelium-dependent vasodilatation and negatively with …”

Section: Discussionmentioning

confidence: 93%

Adiponectin and leptin serum concentrations in patients with rheumatoid arthritis

2009

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International audienceAdipose tissue is regarded as an active metabolic and endocrine organ producing adipokines. The purpose of the study was to evaluate adiponectin and leptin concentrations in rheumatoid arthritis (RA) patients (pts) in relation to disease duration and activity. The study group consisted of 80 RA pts. Serum adiponectin and leptin concentrations remained within normal ranges. Adiponectin concentration correlated positively both with the age and disease duration. Both adipokines levels correlated negatively with glomerular filtration rate. There were significant positive correlations between adipokines' concentrations and lipid profile components (between adiponectin and HDL-cholesterol, leptin and total cholesterol and LDL-cholesterol). In pts with long-standing RA, there was a negative correlation between adiponectin and numbers of tender, swollen joints and a positive relationship between leptin level and DAS28. The results confirm adipokines' involvement in the process of inflammation and atherosclerosis: protective and antiinflammatory adiponectin effect and proatherogenic and proinflammatory leptin function

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Section: Discussionmentioning

confidence: 93%

Adiponectin and leptin serum concentrations in patients with rheumatoid arthritis

2009

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“…Leptin in RA. Leptin concentrations were shown to be increased in the synovial fluid of patients with RA (44,45). The question of whether serum levels of leptin are increased in RA is controversial (27,(46)(47)(48)(49).…”

Section: Adiponectin In Ramentioning

confidence: 99%

Adipocytokines as driving forces in rheumatoid arthritis and related inflammatory diseases?

Neumann

Frommer

Vasile

et al. 2011

Arthritis & Rheumatism

100

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“…Gunaydin et al 26 indicated lack of difference between serum leptin levels of RA patients treated with methotrexate. In a study by Härle et al, 27 the authors reported that clinical and biochemical activation parameters of inflammation in RA patients treated with adalimumab had decreased without any change in leptin levels.…”

Section: Discussionmentioning

confidence: 99%

Relationship Between Leptin and Neopterin Levels and Disease Activation Parameters in Patients With Rheumatoid Arthritis

et al. 2016

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No change of serum levels of leptin and adiponectin during anti-tumour necrosis factor antibody treatment with adalimumab in patients with rheumatoid arthritis

Cited by 66 publications

References 11 publications

Adiponectin and leptin serum concentrations in patients with rheumatoid arthritis

Adiponectin and leptin serum concentrations in patients with rheumatoid arthritis

Adipocytokines as driving forces in rheumatoid arthritis and related inflammatory diseases?

Relationship Between Leptin and Neopterin Levels and Disease Activation Parameters in Patients With Rheumatoid Arthritis

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