Adiponectin and leptin serum concentrations in patients with rheumatoid arthritis

Targońska-Stępniak, Bożena; Dryglewska, Magdalena; Majdan, Maria

doi:10.1007/s00296-009-1053-x

Cited by 56 publications

(53 citation statements)

References 37 publications

(46 reference statements)

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“…Regarding the association of leptin with RA duration and activity, results are also inconclusive. Leptin level was demonstrated to be independent of RA activity or duration in different studies [8, 12, 13, 32]. But, there are also other studies in which, serum leptin was correlated to RA activity and/or duration [2, 4, 5].…”

Section: Discussionmentioning

confidence: 99%

Absence of a positive correlation between CRP and leptin in rheumatoid arthritis

Najafizadeh

Farahmand

Roudsari

et al. 2016

Heliyon

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AimsRheumatoid Arthritis (RA) is a model of chronic inflammatory disease. In this study we evaluated the correlation of leptin and CRP in patients with RA and normal controls.Main methodsA total of 75 patients with RA and 40 healthy adults were recruited in this case-control study. RA patients were categorized into high (DAS–28 > 3.2) and low activity (DAS ≤ 3.2) group according to their DAS-28 score.Key findingsLeptin level was significantly correlated with CRP in healthy controls (r = 0.365; p < 0.05), but this correlation was lost in RA patients (r = 0.095, p = 0.41). Patients with RA had higher serum leptin levels compared to healthy controls (P < 0.01). No difference in serum leptin level was observed between patients with high and low activity disease. Also leptin was correlated with BMI in healthy controls (r = 0.326, p = 0.037). This correlation was not present in RA patients (r = 0.039, p = 0.756).SignificanceWe observed that the physiologic correlation between leptin and CRP and BMI and CRP was not present RA patients. This is a new study reporting the lost correlation between leptin and CRP in RA patients.

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Section: Discussionmentioning

confidence: 99%

Absence of a positive correlation between CRP and leptin in rheumatoid arthritis

Najafizadeh

Farahmand

Roudsari

et al. 2016

Heliyon

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“…Leptin is proinflammatory adipokine involved in different inflammatory diseases such as rheumatoid arthritis 29. It is produced mainly by fat tissue and is always correlated with BMI and TNF-α and is also higher in obese individuals.…”

Section: Discussionmentioning

confidence: 99%

Increased leptin/leptin receptor pathway affects systemic and airway inflammation in COPD former smokers

Bruno¹,

Alessi²,

Soresi³

et al. 2011

JIR

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BackgroundLeptin, a hormone produced mainly by adipose tissue, regulates food intake and energy expenditure. It is involved in inflammatory diseases such as chronic obstructive pulmonary disease (COPD) and its deficiency is associated with increased susceptibility to the infection. The leptin receptor is expressed in the lung and in the neutrophils.MethodsWe measured the levels of leptin, tumor necrosis factor alpha (TNF-α) and soluble form of intercellular adhesion molecule-1 (sICAM-1) in sputum and plasma from 27 smoker and former smoker patients with stable COPD using ELISA methods. Further we analyzed leptin and its receptor expression in sputum cells from 16 COPD patients using immunocytochemistry.ResultsIn plasma of COPD patients, leptin was inversely correlated with TNF-α and positively correlated with the patient weight, whereas the levels of sICAM-1 were positively correlated with TNF-α. In sputum of COPD patients leptin levels were correlated with forced expiratory volume in 1 second/forced vitality capacity. Additionally, increased levels of sputum leptin and TNF-α were observed in COPD former smokers rather than smokers. Further the expression of leptin receptor in sputum neutrophils was significantly higher in COPD former smokers than in smokers, and the expression of leptin and its receptor was positively correlated in neutrophils of COPD former smokers.ConclusionOur findings suggest a role of leptin in the local and systemic inflammation of COPD and, taking into account the involvement of neutrophils in this inflammatory disease, describe a novel aspect of the leptin/leptin receptor pathway in the regulation of host defense after smoking cessation.

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“…Some, but not all, studies have found altered circulating levels of adipokines in patients with RA, and associations of adipokine levels with disease activity and with antiTNF treatment have been inconsistent. [60][61][62] Further research is required to elucidate the complex relationship between insulin r esistance, a dipokines and inflammation in RA.…”

Section: Diabetes and Insulin Resistancementioning

confidence: 99%

Atherosclerosis in rheumatoid arthritis: is it all about inflammation?

2015

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Rheumatoid arthritis (RA) has long been associated with increased cardiovascular risk, but despite substantial improvements in disease management, mortality remains high. Atherosclerosis is more prevalent in RA than in the general population, and atherosclerotic lesions progress at a faster rate and might be more prone to rupture, causing clinical events. Cells and cytokines implicated in RA pathogenesis are also involved in the development and progression of atherosclerosis, which is generally recognized as an inflammatory condition. The two diseases also share genetic and environmental risk factors, which suggests that patients who develop RA might also be predisposed to developing cardiovascular disease. In RA, inflammation and atherosclerosis are closely linked. Inflammation mediates its effects on atherosclerosis both through modulation of traditional risk factors and by directly affecting the vessel wall. Treatments such as TNF inhibitors might have a beneficial effect on cardiovascular risk. However, whether this benefit is attributable to effective control of inflammation or whether targeting specific cytokines, implicated in atherosclerosis, provides additional risk reduction is unclear. Further knowledge of the predictors of cardiovascular risk, the effects of early control of inflammation and of drug-specific effects are likely to improve the recognition and management of cardiovascular risk in patients with RA.

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Adiponectin and leptin serum concentrations in patients with rheumatoid arthritis

Cited by 56 publications

References 37 publications

Absence of a positive correlation between CRP and leptin in rheumatoid arthritis

Absence of a positive correlation between CRP and leptin in rheumatoid arthritis

Increased leptin/leptin receptor pathway affects systemic and airway inflammation in COPD former smokers

Atherosclerosis in rheumatoid arthritis: is it all about inflammation?

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