No association of the insulin gene VNTR polymorphism with polycystic ovary syndrome in a Han Chinese population

Xu, Yuping; Wei, Zhaolian; Zhang, Zhiguo; Xing, Qinghe; Hu, Pin Jin; Zhang, Xiaohui; Gao, Guihua; Wang, Yong; Gao, Qian; Yi, Long; Cao, Yunxia

doi:10.1186/1477-7827-7-141

Cited by 23 publications

(14 citation statements)

References 18 publications

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“…Exenatide is believed to exert its beneficial effect in the endocrine pancreas by maintaining optimal b-cell mass and function by increasing the b-cell gene expression. In turn, this may lead to b-cell proliferation and neogenesis, thereby inhibiting apoptosis in pancreatic islet cells (Xu et al 2009). Exenatide can also exert its secretagogue effect on insulin release by activating GLP1r in the b-cells.…”

Section: Effect Of Exenatide On Metabolic Parametersmentioning

confidence: 99%

Mechanism of the beneficial and protective effects of exenatide in diabetic rats

Lotfy

Singh

Rashed

et al. 2013

Journal of Endocrinology

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Glucagon-like peptide 1 (GLP1) agonists are promising therapeutic agents in the treatment of diabetes mellitus. This study examines the mechanism of the protective effects of exenatide in experimental diabetes, employing four groups of ten rats each, in which two groups were streptozotocin-induced diabetic and two were control groups. One control and one diabetic group were treated with exenatide (1 mg/kg body weight (BW)) for 10 weeks. Blood plasma was taken for biochemical analyses while pancreatic tissue was taken for immunofluorescence and immunoelectron microscopy studies and real-time PCR to examine the expression of genes. The results show that exenatide improved BW gain and reduced blood glucose in diabetic rats compared with controls. Similarly, exenatide enhanced insulin release from the pancreatic fragments and improved liver and kidney functions and lipid profile in diabetic rats compared with controls. Exenatide not only induced significant increases in serum insulin level but also elevated the number of insulin-, GLP1-and exenatide-positive cells compared with untreated controls. Exenatide also elevated the number of catalase-and glutathione reductase-positive cells in diabetic rat pancreas compared with controls. Exenatide caused significant elevation in the expressions of pancreatic duodenal homeobox-1, heat shock protein-70, glutathione peroxidase, insulin receptor and GLP1 receptor genes in the pancreas of both control and diabetic rats compared with untreated animals. The results have demonstrated that exenatide can exert its beneficial and protective effects by elevating the levels of endogenous antioxidants and genes responsible for the survival, regeneration and proliferation of pancreatic b-cell.

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Section: Effect Of Exenatide On Metabolic Parametersmentioning

confidence: 99%

Mechanism of the beneficial and protective effects of exenatide in diabetic rats

Lotfy

Singh

Rashed

et al. 2013

Journal of Endocrinology

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“…Ferk found significant association between class III VNTR alleles and PCOS in 117 cases and 108 healthy controls from Slovenia [15]. However, these findings have not been replicated consistently; including studies with much larger data sets and different ethnic backgrounds [16][17][18][19] and therefore, contribution of INS to the etiology of PCOS is still in controversial.…”

Section: Insulin (Ins) Gene Polymorphism In Pcosmentioning

confidence: 93%

Past, Present and Future of Insulin Gene and Its Related Genes In Relation To Polycystic Ovary Syndrome

Kumar¹

2014

J Mol Genet Med

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Polycystic ovary syndrome is the most common endocrinal disorder and is associated with infertility. Insulin resistance is a key component in the pathogenesis of PCOS and the predisposition to Type 2 diabetes mellitus. The existing literature supports a strong basis of PCOS clusters in families. However, due to the genetic and phenotypic heterogeneity of PCOS and the lack of large cohort studies and identification of specific contributing genes to date have yielded only few conclusive results. Although several loci have been proposed as PCOS genes including CYP11A, the insulin gene, and a region near the insulin receptor, the strongest case can be made for the region near the insulin receptor gene. Insulin receptor substrates proteins (IRS) are critical for insulin mediated signal transduction in insulin target tissues. Several studies have shown that IRS-1 Gly972Arg polymorphism might be the factor causing susceptibility to Type 2 diabetes mellitus (T2DM) and are associated with phenotypic features of PCOS. In this article we reviewed the current status of the genetic analysis of insulin (INS), insulin receptor (INSR), insulin receptor substrate (IRS) in relation to polycystic ovary syndrome, an infertility disorder in females.

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“…In total, 13 case-control studies [21][22][23][24][25][26][27][28][29][30] including 1,767 cases and 4,181 controls, were included in the analysis. Waterworth DM [21] and Powell BL [23] were conducted on the anovulatory PCOS.…”

Section: Baseline Characteristicsmentioning

confidence: 99%

Lack of association of INS VNTR polymorphism with polycystic ovary syndrome: a meta-analysis

Song

Luo

Peng

et al. 2014

J Assist Reprod Genet

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Purpose An association between the INS VNTR polymorphisms and polycystic ovary syndrome (PCOS) susceptibility has been reported in previous studies, but the results were inconsistent. This study was conducted to explore this association using meta-analysis. Methods PubMed, Embase, and China National Knowledge Infrastructure (CNKI) were searched according to predefined criteria for all relevant studies published up to August 2013. Four genetic models, together with odds ratios (ORs) and 95 % confidence intervals (CI), were calculated. Subgroup analyses were performed by ethnicity, anovulatory PCOS, and Hardy-Weinberg equilibrium (HWE) in the controls. Results In total, 13 case-control studies, including 1,767 cases and 4,108 controls, were included. No significant association was detected in overall population in all models (III/III Conclusions This meta-analysis revealed no significant association between INS VNTR polymorphisms and the risk of PCOS in the overall population, while it supported that variance may be associated with susceptibility to PCOS with anovulation. Further confirmation is needed from more welldesigned and larger studies.

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No association of the insulin gene VNTR polymorphism with polycystic ovary syndrome in a Han Chinese population

Cited by 23 publications

References 18 publications

Mechanism of the beneficial and protective effects of exenatide in diabetic rats

Mechanism of the beneficial and protective effects of exenatide in diabetic rats

Past, Present and Future of Insulin Gene and Its Related Genes In Relation To Polycystic Ovary Syndrome

Lack of association of INS VNTR polymorphism with polycystic ovary syndrome: a meta-analysis

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