Lack of association of INS VNTR polymorphism with polycystic ovary syndrome: a meta-analysis

Abstract

Purpose An association between the INS VNTR polymorphisms and polycystic ovary syndrome (PCOS) susceptibility has been reported in previous studies, but the results were inconsistent. This study was conducted to explore this association using meta-analysis. Methods PubMed, Embase, and China National Knowledge Infrastructure (CNKI) were searched according to predefined criteria for all relevant studies published up to August 2013. Four genetic models, together with odds ratios (ORs) and 95 % confidence intervals (CI), were calculated. Subgroup analyses were performed by ethnicity, anovulatory PCOS, and Hardy-Weinberg equilibrium (HWE) in the controls. Results In total, 13 case-control studies, including 1,767 cases and 4,108 controls, were included. No significant association was detected in overall population in all models (III/III Conclusions This meta-analysis revealed no significant association between INS VNTR polymorphisms and the risk of PCOS in the overall population, while it supported that variance may be associated with susceptibility to PCOS with anovulation. Further confirmation is needed from more welldesigned and larger studies.

Pathophysiologic Mechanisms of Insulin Secretion and Signaling-Related Genes in Etiology of Polycystic Ovary Syndrome

“…Nevertheless, due to the impact of insulin resistance and hyperinsulinemia on anovulation, there may be an association between insulin-related genes and ovulation. While in a meta-analysis study, no association between INS VNTR gene and PCOS was observed [ 63 ], INS VNTR class III allele is correlated with increased HOMA-IR and BMI in Kashmiri women with PCOS [ 64 ]. A set of previous studies have shown that the variable number of tandem repeat of INS gene is not likely to be dependent on PCOS in different populations ( Table 2 ).…”