No association of the CD45 77C>G transversion with inflammatory bowel disease in German patients

Abstract

A 77C>G transversion in exon A of the CD45 gene was investigated in patients with inflammatory bowel disease (IBD) and controls. The distribution of the 77G allele was not significantly different between patients and controls. We found no evidence for the contribution of the 77C>G transversion in susceptibility to IBD.

No association between transmembrane protein–tyrosine–phosphatase receptor type C (CD45) exon A 77C>G transversion and Hashimoto's thyroiditis in a German population

“…This 77CϾG transversion has been suggested by some investigators to be associated with multiple sclerosis, although other studies could not confirm such an association [9 -12]. Negative results were also obtained for the autoimmune diseases diabetes mellitus type I, rheumatoid arthritis, inflammatory bowel disease, and idiopathic dilated cardiomyopathy [13][14][15][16][17]. Furthermore, some studies reported an increased frequency of the 77G allele in autoimmune hepatitis and systemic sclerosis, which was contradicted by recently published studies [18 -21].…”