No association of TAP1 and TAP2 genes polymorphism with risk of cervical cancer in north Indian population

Kordi-Tamandani, Dor Mohammad; Sobti, Ranbir Chander; Shekari, Mohammad; Husseini, Seyd Ali; Suri, Vanita

doi:10.1007/s10815-009-9301-2

Cited by 9 publications

(8 citation statements)

References 20 publications

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“…In particular, SNPs in the LMP7 , TAP2, and ERAP1 have been found to be associated with cervical carcinoma risk, lymph node metastases, and overall survival, both individually and in specific haplotype configurations [ 41 , 45 ]. Though similar gene and haplotype associations have been found in several populations, including Dutch, Indonesian, Austrian Caucasian, North Indian, and North American, the actual genes and gene combinations involved differ greatly between the various populations [ 42 – 44 , 107 ].…”

Section: Antigen-processing Machinerymentioning

confidence: 87%

Cervical Carcinogenesis and Immune Response Gene Polymorphisms: A Review

Mehta

Mooij

Branković

et al. 2017

Journal of Immunology Research

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The local immune response is considered a key determinant in cervical carcinogenesis after persistent infection with oncogenic, high-risk human papillomavirus (HPV) infections. Genetic variation in various immune response genes has been shown to influence risk of developing cervical cancer, as well as progression and survival among cervical cancer patients. We reviewed the literature on associations of immunogenetic single nucleotide polymorphism, allele, genotype, and haplotype distributions with risk and progression of cervical cancer. Studies on HLA and KIR gene polymorphisms were excluded due to the abundance on literature on that subject. We show that multiple genes and loci are associated with variation in risk of cervical cancer. Rather than one single gene being responsible for cervical carcinogenesis, we postulate that variations in the different immune response genes lead to subtle differences in the effectiveness of the antiviral and antitumour immune responses, ultimately leading to differences in risk of developing cervical cancer and progressive disease after HPV infection.

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Section: Antigen-processing Machinerymentioning

confidence: 87%

Cervical Carcinogenesis and Immune Response Gene Polymorphisms: A Review

Mehta

Mooij

Branković

et al. 2017

Journal of Immunology Research

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“…There are several studies on the relationship between TAP (including TAP1 and TAP2) polymorphisms and various carcinoma, and only TAP1 polymorphisms have been confirmed to be susceptible to various tumor types. One study shows that no significant difference in genotype distribution of TAP1 and TAP2 polymorphisms was observed in women with cervical intraepithelial neoplasm (CIN) and controls [ 56 ], and a similar study conducted in India succeeded to reproduce this observation [ 57 ], however, in another similar study, significant differences in allele distribution between women with high-grade cervical neoplasm (CIN II or III) and women without was seen for both TAP1 I333V ( P = 0.02) and TAP1 D637G ( P = 0.01) [ 58 ]. In addition, G allele at TAP1 Codon 637 is associated with nasopharyngeal carcinoma (NPC) in Han population in Yunnan, China (OR, 1.88; 95 % CI, 1.35–2.82; P < 0.001), and EBV pathogenesis in NPC might be facilitated by polymorphisms in the TAP1 proteins [ 59 ].…”

Section: Discussionmentioning

confidence: 99%

Heterozygote of TAP1 Codon637 decreases susceptibility to HPV infection but increases susceptibility to esophageal cancer among the Kazakh populations

Zou

Yang

Chen

et al. 2015

J Exp Clin Cancer Res

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BackgroundThe role of human papillomavirus (HPV) may be involved in the development of esophageal cancer (EC) and the polymorphic immune response gene transporter associated with antigen processing (TAP) may be involved in HPV persistence and subsequent cancer carcinogenesis. The current study aims to provide association evidence for HPV with EC, to investigate TAP1 polymorphisms in EC and assess its association with HPV statuses and EC in Kazakhs.MethodsThe HPV genotypes in 361 patients with EC and 66 controls selected from Kazakh population were evaluated using PCR. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was performed to detect two SNPs of TAP1 in 150 cases comprised of 75 HPV+ and 75 HPV- patients and 283 pure ethnic population of Kazakh and evaluate their associations with susceptibility to EC. A case-to-case comparison based on the genotyping results was conducted to address the function of TAP1 variants in the involvement of HPV.ResultsThe presence of four HPV genotypes in EC tissues ― including HPV 16, 18, 31, 45 ― was significantly higher at 64.6 % than those in controls at 18.2 % (P < 0.001). Such presence was strongly associated with increased risk of EC (OR 8.196; 95 % CI 4.280–15.964). The infection of HPV16, and multi-infection of 16 and 18 significantly increase the risk for developing EC (OR 4.616, 95 % CI 2.099–10.151; and OR 6.029, 95 % CI 1.395–26.057 respectively). Heterozygote of TAP1 D637G had a significantly higher risk for developing EC (OR 1.626; 95 % CI 1.080–2.449). The odds ratio for HPV infection was significantly lower among carriers of TAP1 D637G polymorphism (OR 0.281; 95 % CI 0.144–0.551).ConclusionsHPV infection exhibits a strong positive association with the risk of EC in Kazakhs. Heterozygote of TAP1 D637G decreases susceptibility to HPV infection in patients with EC but increases susceptibility to EC among the Kazakh populations.

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“…17,30 After the removal of all investigations that did not meet our criteria, seven articles were included for qualitative synthesis. [9][10][11][12][13]15,16 One article was further separated into three studies, as it investigated different cancer types. Finally, a total of nine case-control studies with 2800 cases and 1620 controls were pooled into the meta-analysis.…”

Section: Study Characteristicsmentioning

confidence: 99%

Quantitative assessment of the association between TAP2 rs241447 polymorphism and cancer risk

Liu

Chen

2019

J of Cellular Biochemistry

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The findings regarding the relation of transporter associated with antigen processing (TAP) to cancer risk have been inconsistent. The aim of this study was to comprehensively evaluate the association between TAP2 rs241447 polymorphism and cancer susceptibility. A meta‐analysis of nine investigations with 2800 cases and 1620 controls was conducted to gain a better understanding of the effect of TAP2 rs241447 polymorphism on cancer risk. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to evaluate the strength of the correlation between TAP2 gene polymorphism and cancer susceptibility. The pooled results from TAP2 rs241447 polymorphism showed a decreased risk of cancer in two dominant genetic models (GG + AG vs AA: OR = 0.86, 95% CI, 0.75‐0.99; AG vs AA: OR = 0.85, 95% CI, 0.73‐0.99). From the subgroup analysis, decreased cancer susceptibility was found in Caucasians (GG + AG vs AA: OR = 0.82, 95% CI, 0.68‐0.99), especially among the subgroup of cervical carcinoma (GG + AG vs AA: OR = 0.82, 95% CI, 0.69‐0.96; AG vs AA: OR = 0.83, 95% CI, 0.70‐0.99). Overall, the results suggest that TAP2 rs241447 polymorphism contributes to decreased cancer susceptibility.

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No association of TAP1 and TAP2 genes polymorphism with risk of cervical cancer in north Indian population

Abstract: Thus, TAP1 and TAP2 genes polymorphism are not linked to cervical carcinoma, since no association was found between a particular genotype and the disease.

Cited by 9 publications

References 20 publications

Cervical Carcinogenesis and Immune Response Gene Polymorphisms: A Review

Cervical Carcinogenesis and Immune Response Gene Polymorphisms: A Review

Heterozygote of TAP1 Codon637 decreases susceptibility to HPV infection but increases susceptibility to esophageal cancer among the Kazakh populations

Quantitative assessment of the association between TAP2 rs241447 polymorphism and cancer risk

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