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Levin, A. D.; Pribytkov, V. A.; Rukin, E. M.; Серегина, И. Ф.

doi:10.1023/a:1012339901875

Cited by 3 publications

(1 citation statement)

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“…AAS has been widely applied for estimation of residual active pharmaceutical ingredients in specimens of cleaning validation [2], environmental measurements [3,4], direct as well as the indirect assay of compounds of pharmaceutical interest [5,6].…”

Section: Introductionmentioning

confidence: 99%

Green Atomic Absorption Spectroscopic Methods for the Determination of Rabeprazole Sodium and Fluvastatin Sodium in Pure and Pharmaceutical Dosage Forms

Kamal

Morshedy

Saad

et al. 2021

IRJPAC

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Aims: Novel green analytical methods have been proposed for the assay of Rabeprazole sodium and Fluvastatin sodium in their pure and formulated dosage forms. Study Design: The methods determine each drug through the estimation of its sodium content, using Flame Atomic Absorption Spectroscopy at wavelength 589 nm. Place and Duration of Study: Central laboratory at Faculty of Pharmacy, Damanhour University. Time duration January-March, 2020. Methodology: Methods are developed and optimized for maximum sensitivity, selectivity and degree of greenness. Linearity is achieved in the range of 8.29- 66.33 ppm of Rabeprazole sodium (equivalent to 0.5- 4 ppm Na) and 14.13- 141.32 ppm of Fluvastatin sodium (equivalent to 0.75 -7.5 ppm Na). The proposed assays are fully validated regarding ICH guidelines. Results: Atomic spectroscopic assays are compared to reported spectrophotometric ones for each drug separately using Student t-test and F-variance ratio. Conclusion: Satisfactory values indicate good agreement and the insignificant difference between both methods. The obtained percentages of recovery (99-101%) indicate no interference from excipients in formulation matrices.

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Section: Introductionmentioning

confidence: 99%

Green Atomic Absorption Spectroscopic Methods for the Determination of Rabeprazole Sodium and Fluvastatin Sodium in Pure and Pharmaceutical Dosage Forms

Kamal

Morshedy

Saad

et al. 2021

IRJPAC

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ToF-SIMS analysis of elemental distributions in human hair

Kempson

Skinner

2005

Science of The Total Environment

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Copper and Human Health- A Review

Karim¹

2018

J. Bahria Uni. Med. Dent. Coll.

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Copper (Cu), is an essential trace element. Along with lead, arsenic, mercury, cadmium etc. it is classified as a member of heavy metal group. Deficiency of copper is involved in the etiology and promotion of many disease processes related to gastrointestinal and neurological systems as well as affect functions of heart, blood vessel, pancreas etc. Deficiency of copper in early part of gestation can produce major organ malformations in the developing fetus and this in turn if persistently present can lead to neurological as well as immunological abnormalities in the newborn. Conversely presence of enormous concentrations of copper is also a great danger for the human health. Acute copper toxicity predisposes to various pathological conditions and can cause death in severe cases. Chronic exposure to copper produces anemia, liver toxicity and severe neurological defects.

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Cited by 3 publications

References 1 publication

Green Atomic Absorption Spectroscopic Methods for the Determination of Rabeprazole Sodium and Fluvastatin Sodium in Pure and Pharmaceutical Dosage Forms

Green Atomic Absorption Spectroscopic Methods for the Determination of Rabeprazole Sodium and Fluvastatin Sodium in Pure and Pharmaceutical Dosage Forms

ToF-SIMS analysis of elemental distributions in human hair

Copper and Human Health- A Review

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