NMR Spectroscopy in Forensic Science

Groombridge, Christopher J.

doi:10.1016/s0066-4103(08)60080-0

Cited by 16 publications

(7 citation statements)

References 216 publications

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“…A more complex and tough issue, which has not fully addressed yet, is the biological investigation of the metabolic pathways related to an acute or a chronic assumption of one, or more substances, and their potential pathognomonic signature on the human metabolome. NMR spectroscopy has been widely used for forensic purposes to characterize drugs and their metabolites in human and animal biological matrices (Groombridge 1996;Nicholas et al 2006;Liu et al 2010;Santos et al 2018;Dinis-Oliveira 2019). In the present review, we focused on the 1 H NMR metabolomic studies dealing with the effects of addictive drugs on the endogenous metabolomic profile, which may be used to address their biological effects in view of the description of a putative substance-specific phenotype.…”

Section: Drug-induced Biological Effects On the Metabolomementioning

confidence: 99%

“…NMR spectroscopy has been widely used for forensic purposes to characterize drugs and their metabolites in human and animal biological matrices (Groombridge 1996 ; Nicholas et al 2006 ; Liu et al 2010 ; Santos et al 2018 ; Dinis-Oliveira 2019 ). In the present review, we focused on the 1 H NMR metabolomic studies dealing with the effects of addictive drugs on the endogenous metabolomic profile, which may be used to address their biological effects in view of the description of a putative substance-specific phenotype.…”

Section: Drug-induced Biological Effects On the Metabolomementioning

confidence: 99%

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Forensic NMR metabolomics: one more arrow in the quiver

et al. 2020

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Introduction NMR metabolomics is increasingly used in forensics, due to the possibility of investigating both endogenous metabolic profiles and exogenous molecules that may help to describe metabolic patterns and their modifications associated to specific conditions of forensic interest. Objectives The aim of this work was to review the recent literature and depict the information provided by NMR metabolomics. Attention has been devoted to the identification of peculiar metabolic signatures and specific ante-mortem and post-mortem profiles or biomarkers related to different conditions of forensic concern, such as the identification of biological traces, the estimation of the time since death, and the exposure to drugs of abuse. Results and Conclusion The results of the described studies highlight how forensics can benefit from NMR metabolomics by gaining additional information that may help to shed light in several forensic issues that still deserve to be further elucidated.

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Section: Drug-induced Biological Effects On the Metabolomementioning

confidence: 99%

Section: Drug-induced Biological Effects On the Metabolomementioning

confidence: 99%

Forensic NMR metabolomics: one more arrow in the quiver

et al. 2020

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“…One of the most important advantages is that NMR can quickly and accurately provide a wealth of structural information about compounds without destroying the properties of the compound [ 14 , 15 ]. Recently, both liquid and solid NMR instruments have been used to study illicit drugs [ 16 – 19 ].…”

Section: Introductionmentioning

confidence: 99%

The Application of a Desktop NMR Spectrometer in Drug Analysis

Zhong

Huang

Luo

et al. 2018

International Journal of Analytical Chemistry

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A desktop NMR spectrometer was used to qualitatively analyze samples in drug-related cases in order to enhance the accuracy of the results and identify new drugs. Twelve known drugs and their derivatives were used to establish the parameters, conditions, and procedures for the methods and validate the feasibility and reliability of the methods. First, 1-D and 2-D NMR data for these 12 drugs and their derivatives were obtained in detail using a 600-MHz NMR spectrometer to create a data library. Next, some of these 12 drugs were analyzed using a Picospin 80 MHz desktop NMR spectrometer to set up the analytical procedure and method. With the procedure and method established, real case samples were analyzed and the data were compared to those obtained by a standard method. The results indicate that the desktop NMR spectrometer is a reliable and promising approach that can be used in criminology to quickly identify whether or not samples contain illegal drugs.

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“…Confirmation of the drugs is by GC-MS, with suitable derivatisation. Nuclear magnetic resonance (NMR) 20 or HPLC is used to quantify the drugs, but comparison of samples requires GC-MS. The methods of synthesis of the drugs are well known, and levels of impurities expected for each route are known.…”

Section: Drug Analysismentioning

confidence: 99%

Advances in chemistry applied to forensic science

Rendle

2005

Chem. Soc. Rev.

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Acts of terrorism, an increase in the use of firearms, drug abuse, the use of so-called date-rape drugs, and driving whilst under the influence of drugs, are just some of the subjects frequently in the news. In the absence of fingermarks and of material leading to the recovery of DNA, the forensic scientist has to rely upon chemical analysis of trace amounts of materials including explosives, drugs, toxicological specimens, firearms discharge residues, fibres, glass, paint, soil etc., in order to establish or eliminate links between suspect and victim and/or scene. This tutorial review describes analytical problems facing the forensic chemist, and the current methods and techniques employed to tackle them.

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NMR Spectroscopy in Forensic Science

Cited by 16 publications

References 216 publications

Forensic NMR metabolomics: one more arrow in the quiver

Forensic NMR metabolomics: one more arrow in the quiver

The Application of a Desktop NMR Spectrometer in Drug Analysis

Advances in chemistry applied to forensic science

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