NMR of Drug Delivery Coupled with Lipid Membrane Dynamics

Okamura, Emiko

doi:10.1002/9781119075691.ch30

Encyclopedia of Biocolloid and Biointerface Science 2V Set 2016

DOI: 10.1002/9781119075691.ch30

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NMR of Drug Delivery Coupled with Lipid Membrane Dynamics

Emiko Okamura

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2019

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Cited by 2 publications

References 49 publications

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Solution NMR to Quantify Mobility in Membranes: Diffusion, Protrusion, and Drug Transport Processes

Okamura

2019

Chem. Pharm. Bull.

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Lipid bilayer membranes are soft, fluid, and dynamic architecture where molecules are constantly moving and thermally fluctuating under physiological conditions. In this review, a strategy to quantify molecular dynamics in membranes is introduced by utilizing solution-state NMR spectroscopy as a versatile, noninvasive technique. The dynamics involves lateral diffusion and protrusion motion, in parallel and vertical direction to the membrane surface. Dynamical behavior of small-sized drugs, chemicals, and peptides is also reviewed in relation to the lipid movements in membranes, on the basis of recent multinuclear NMR in combination with the pulsed field gradient technique. Finally, in-cell NMR method is introduced as a promising technique to capture drug transport processes in real time, to shed light on mechanisms of deliveries to living cells without perturbation of the system.

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Solution NMR to Quantify Mobility in Membranes: Diffusion, Protrusion, and Drug Transport Processes

Okamura

2019

Chem. Pharm. Bull.

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Uptake of Sevoflurane Limited by the Presence of Cholesterol in the Lipid Bilayer Membrane: A Multinuclear Nuclear Magnetic Resonance Study

2014

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NMR of Drug Delivery Coupled with Lipid Membrane Dynamics

Cited by 2 publications

References 49 publications

Solution NMR to Quantify Mobility in Membranes: Diffusion, Protrusion, and Drug Transport Processes

Solution NMR to Quantify Mobility in Membranes: Diffusion, Protrusion, and Drug Transport Processes

Uptake of Sevoflurane Limited by the Presence of Cholesterol in the Lipid Bilayer Membrane: A Multinuclear Nuclear Magnetic Resonance Study

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