NMR-Based Kinetic Experiments for Undergraduate Chemistry Laboratories

Kantorowski, Eric J.; Ghaffari, Bijan D.; Macrorie, Allee; Candee, Kellan N.; Petraitis, Jennifer M.; Miller, Marina; Warneke, Gayle; Takacs, Michelle; Hancock, Vanessa; Lusth, Zoe A.

doi:10.1021/bk-2013-1128.ch014

Cited by 5 publications

(2 citation statements)

References 11 publications

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“…Historically NMR has been a useful analytical tool to measure reaction kinetics as well as quantification, 21 but often this is not examined at the undergraduate level. Limited examples have been found in the literature that have explored this concept, but they have focused on kinetics in isolation, [22][23][24] thus here we wanted to create a holistic experiment that bridges multiple branches of chemistry. To obtain a fully quantitative NMR, the relaxation time (T 1 ) of the analyte molecules must be known, or measured.…”

Section: Introductionmentioning

confidence: 99%

Brewing alcohol 101: An undergraduate experiment utilizing benchtop NMR for quantification and process monitoring

Jenne,

Soong,

Downey

et al. 2024

Magnetic Reson in Chemistry

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In recent years there has been a renewed interest in benchtop NMR. Given their lower cost of ownership, smaller footprint, and ease of use, they are especially suited as an educational tool. Here, a new experiment targeted at upper‐year undergraduates and first‐year graduate students follows the conversion of D‐glucose into ethanol at low‐field. First, high and low‐field data on D‐glucose are compared and students learn both the Hz and ppm scales and how J‐coupling is field‐independent. The students then acquire their own quantitative NMR datasets and perform the quantification using an Electronic Reference To Access In Vivo Concentration (ERETIC) technique. To our knowledge ERETIC is not currently taught at the undergraduate level, but has an advantage in that internal standards are not required; ideal for following processes or with future use in flow‐based benchtop monitoring. Using this quantitative data, students can relate a simple chemical process (fermentation) back to more complex topics such as reaction kinetics, bridging the gaps between analytical and physical chemistry. When asked to reflect on the experiment, students had an overwhelmingly positive experience, citing agreement with learning objectives, ease of understanding the protocol, and enjoyment. Each of the respondents recommended this experiment as a learning tool for others. This experiment has been outlined for other instructors to utilize in their own courses across institutions, with the hope that a continued expansion of low‐field NMR will increase accessibility and learning opportunities at the undergraduate level.

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Section: Introductionmentioning

confidence: 99%

Brewing alcohol 101: An undergraduate experiment utilizing benchtop NMR for quantification and process monitoring

Jenne,

Soong,

Downey

et al. 2024

Magnetic Reson in Chemistry

View full text Add to dashboard Cite

show abstract

“…Nuclear magnetic resonance (NMR) as a well-known characterization tool has found lately its application in monitoring chemical reaction progression as well as providing practical insights into the structure–property relationships. 17,18 Likewise, NMR found its place in studying polymer gel systems for conformance control applications. 19 While the majority of the studies in the literature employed the NMR experiments to mainly characterize the structures of the reactants (polymer/crosslinker), the unique study which demonstrated the gelation reaction and gel state kinetics was reported by Romero-zeron et al 20 using a PHPA/chromium( iii ) acetate system.…”

Section: Introductionmentioning

confidence: 99%