NMDAR1 isoforms in the rat superior olivary complex and changes after unilateral cochlear ablation

Nakagawa, Hiroe; Sato, Kazuo; Shiraishi, Yuri; Kuriyama, Hiromichi; Altschuler, Richard A.

doi:10.1016/s0169-328x(00)00059-0

Cited by 44 publications

(9 citation statements)

References 56 publications

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“…There are three NR1 spliced variants expressed in the MNTB (NR1a > 1b > 1–4 and 11) but NR1–3 was not detected (Nakagawa et al 2000). The NR1‐1b spliced‐variant containing exon 5 is associated with a somatic location (Pal et al 2003) and fast deactivation kinetics (Rumbaugh et al 2000).…”

Section: Discussionmentioning

confidence: 99%

NMDAR-mediated EPSCs are maintained and accelerate in time course during maturation of mouse and rat auditory brainstemin vitro

Steinert

Postlethwaite

Jordan

et al. 2010

The Journal of Physiology

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NMDA receptors (NMDARs) mediate a slow EPSC at excitatory glutamatergic synapses throughout the brain. In many areas the magnitude of the NMDAR-mediated EPSC declines with development and is associated with changes in subunit composition, but the mature channel composition is often unknown. We have employed the calyx of Held terminal with its target, the principal neuron of the medial nucleus of the trapezoid body (MNTB), to examine the NMDAR-mediated EPSC during synapse maturation from P10 to P40. Our data show that the calyx has reached a mature state by around P18. α-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate (receptor); AP, action potential; D-AP5, D-2-amino-5-phosphonovalerate; GluRDo, glutamate receptor subunit 4 (or D) flop spliced variant; HP, holding potential; Kv3, voltage-gated K + channel, third family; MNTB, medial nucleus of the trapezoid body; NMDA(R), N -methyl-D-aspartate (receptor); NR1 and NR2, NMDA receptor subunits; qPCR, quantitative real time PCR; RT, room temperature; tPA, tissue plasminogen activator.

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Section: Discussionmentioning

confidence: 99%

NMDAR-mediated EPSCs are maintained and accelerate in time course during maturation of mouse and rat auditory brainstemin vitro

Steinert

Postlethwaite

Jordan

et al. 2010

The Journal of Physiology

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“…Author Manuscript changes in amino acid neurotransmitters and receptors (Bledsoe et al, 1995;Potashner et al, 1997Potashner et al, , 2000Milbrandt et al, 1997;Ryugo et al, 1998;Caspary et al, 1999;Helfert et al, 1999;Mossop et al, 2000;Nakagawa et al, 2000; Sato et al, 2000a,b;Holt et al, 2005), in ion channels (Macica et al, 2003;Lu et al, 2004;von Hehn et al, 2004), as well as in synapse-related proteins such as protein kinases, Gap43, calbindin, ERK, SAPK, NT3 and BDNF (Idrizbegovic et al, 1998;Garcia et al, 2000;Illing and Michler, 2001; Suneja and Potashner, 2003b). Thus, there is a resulting influence on the balance between excitation and inhibition reflected in changes in neuronal response profiles (Bledsoe et al, 1995;Caspary et al, 1995;Francis and Manis, 2000;Kaltenbach and Afman, 2000;Mossop et al, 2000;Salvi et al, 2000;Syka and Rybalko, 2000) as well as in changes in tonotopic maps (Willott et al, 1982(Willott et al, , 1993Robertson and Irvine, 1989;Schwartz et al, 1993;Rajan and Irvine, 1998;Salvi et al, 1999;Nagase et al, 2000).…”

Section: Author Manuscript Author Manuscriptmentioning

confidence: 99%

Changes in glycine immunoreactivity in the rat superior olivary complex following deafness

et al. 2005

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The balance between inhibitory and excitatory amino acid neurotransmitters contributes to the control of normal functioning of the auditory brainstem. Changes in the level of neuronal activity within the auditory brainstem pathways influence the balance between inhibition and excitation. Activity-dependent plasticity in the auditory pathways can be studied by creating a large decrease in activity through peripheral deafening. Deafness-related decreases in GABA have previously been shown in the inferior colliculus. However, glycine is a more prevalent inhibitory transmitter in the mature superior olivary complex (SOC). The present study therefore examined if there were deafness-related changes in glycine in the SOC using postembedding immunocytochemistry. Animals were bilaterally deafened by an intrascalar injection of neomycin. Five nuclei in the SOC, the lateral superior olive (LSO), superior paraolivary nucleus (SPoN), and the medial, lateral, and ventral nuclei of the trapezoid body (MNTB, LNTB, and VNTB) were examined 14 days following the deafening and compared to normal hearing age-matched controls. The LSO and SPoN were divided into high and low frequency regions. The number of glycine immunoreactive puncta on the somata of principal cells showed significant decreases in all regions assessed, with changes ranging from 50% in the VNTB to 23% in the LSO. J. Comp. Neurol. 494:179-189, 2006. Indexing termsauditory; brainstem; neomycin; superior olivary complex Increases or decreases in activity induce plastic changes in the mature auditory pathways (recently reviewed by Syka, 2002; and more generally by Møller 2001, 2005). There is deafness-associated plasticity at the synaptic level in the mature auditory brainstem, with HHS Public Access Author Manuscript Author ManuscriptAuthor ManuscriptAuthor Manuscript changes in amino acid neurotransmitters and receptors (Bledsoe et al., 1995;Potashner et al., 1997Potashner et al., , 2000Milbrandt et al., 1997;Ryugo et al., 1998;Caspary et al., 1999;Helfert et al., 1999;Mossop et al., 2000;Nakagawa et al., 2000; Sato et al., 2000a,b;Holt et al., 2005), in ion channels (Macica et al., 2003;Lu et al., 2004;von Hehn et al., 2004), as well as in synapse-related proteins such as protein kinases, Gap43, calbindin, ERK, SAPK, NT3 and BDNF (Idrizbegovic et al., 1998;Garcia et al., 2000;Illing and Michler, 2001; Suneja and Potashner, 2003b). Thus, there is a resulting influence on the balance between excitation and inhibition reflected in changes in neuronal response profiles (Bledsoe et al., 1995;Caspary et al., 1995;Francis and Manis, 2000;Kaltenbach and Afman, 2000;Mossop et al., 2000;Salvi et al., 2000;Syka and Rybalko, 2000) as well as in changes in tonotopic maps (Willott et al., 1982(Willott et al., , 1993Robertson and Irvine, 1989;Schwartz et al., 1993;Rajan and Irvine, 1998;Salvi et al., 1999;Nagase et al., 2000). A shift towards decreased inhibition and increased excitation has been reported in the CIC (Vale and Sanes, 2002) associated with decreases in GAB...

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“…Both of these effects are thought to be mediated by antagonism of the N-methyl-D-aspartate glutamate receptor (NMDAR; Anis et al, 1983; Harrison and Simmonds, 1985). NMDARs are widely distributed in auditory brainstem structures, including the SPON (Petralia et al, 1994a, b; Sato et al, 1999), cochlear nucleus (Bilak et al, 1996; Sato et al, 1998; Petralia et al, 1994a, b; 2000) and MNTB (Petralia et al, 1994a, b; Sato et al, 1999; Nakagawa et al, 2000). Moreover, in-vivo and in-vitro physiological studies of the auditory brainstem and midbrain have shown that pharmacologic blockade of NMDARs reduces excitability in many cell types ( cochlear nucleus: Martin, 1985; Isaacson and Walmsley, 1995; Ferragamo et al, 1998; lateral superior olive: Caspary and Faingold, 1989; Wu and Kelly, 1992; medial superior olive: Smith et al, 2000; MNTB: Forsythe and Barnes-Davies, 1993; Hamann et al, 2003; auditory midbrain: Faingold et al, 1989; Feldman and Knudsen, 1994; Zhang and Kelly, 2001; Wu et al, 2002; Sanchez et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Effects of ketamine on response properties of neurons in the superior paraolivary nucleus of the mouse

2012

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The superior paraolivary nucleus (SPON; alternative abbreviation: SPN for the same nucleus in certain species) is a prominent brainstem structure that provides strong inhibitory input to the auditory midbrain. Previous studies established that SPON neurons encode temporal sound features with high precision. These earlier characterizations of SPON responses were recorded under the influence of ketamine, a dissociative anesthetic agent and known antagonist of NMDA receptors. Because NMDA alters neural responses from the auditory brainstem, single unit extracellular recordings of SPON neurons were performed in the presence and absence of ketamine. In doing so, this study represents the first in-vivo examination of the SPON of the mouse. Herein, independent data sets of SPON neurons are characterized that did or did not receive ketamine, as well as neurons that were recorded both prior to and following ketamine administration. In all conditions, SPON neurons exhibited contralaterally-driven spikes triggered by the offset of pure tone stimuli. Ketamine lowered both evoked and spontaneous spiking, decreased the sharpness of frequency tuning and increased auditory thresholds and first-spike latencies. In addition, ketamine limited the range of modulation frequencies to which neurons phase-locked to sinusoidally amplitude-modulated tones.

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NMDAR1 isoforms in the rat superior olivary complex and changes after unilateral cochlear ablation

Cited by 44 publications

References 56 publications

NMDAR-mediated EPSCs are maintained and accelerate in time course during maturation of mouse and rat auditory brainstemin vitro

NMDAR-mediated EPSCs are maintained and accelerate in time course during maturation of mouse and rat auditory brainstemin vitro

Changes in glycine immunoreactivity in the rat superior olivary complex following deafness

Effects of ketamine on response properties of neurons in the superior paraolivary nucleus of the mouse

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