Effects of ketamine on response properties of neurons in the superior paraolivary nucleus of the mouse

Felix, Richard A.; Kadner, Alexander; Berrebi, Albert S.

doi:10.1016/j.neuroscience.2011.11.027

Cited by 16 publications

(16 citation statements)

References 77 publications

(117 reference statements)

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“…In relating the results of these previous studies to the present results, one must take into account that the auditory systems of all species studied display unique adaptations, and each study was subject to the effects of its anesthesia protocol and recording methodology. In the present study, the known effects of ketamine anesthesia include increased peak latencies of auditory evoked potentials (Church and Gritzke 1987; Smith and Mills 1989, 1991), increased thresholds of auditory brainstem responses (van Looij et al 2004), decreased sound evoked and spontaneous spiking, and reduced the sharpness of frequency tuning (Felix et al 2012). Therefore comparisons between studies must be approached with caution.…”

Section: Discussionmentioning

confidence: 89%

Forward masking in the medial nucleus of the trapezoid body of the rat

Gao

Berrebi

2015

Brain Struct Funct

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Perception of acoustic stimuli is modulated by the temporal and spectral relationship between sound components. Forward masking experiments show that the perception threshold for a probe tone is significantly impaired by a preceding masker stimulus. Forward masking has been systematically studied at the level of the auditory nerve, cochlear nucleus, inferior colliculus and auditory cortex, but not yet in the superior olivary complex. The medial nucleus of the trapezoid body (MNTB), a principal cell group of the superior olive, plays an essential role in sound location. The MNTB receives excitatory input from the contralateral cochlear nucleus via the calyces of Held and innervates the ipsilateral lateral and medial superior olives (LSO and MSO), as well as the superior paraolivary nucleus (SPON). Here, we performed single-unit extracellular recordings in the MNTB of rats. Using a forward-masking paradigm previously employed in studies of the inferior colliculus and auditory nerve, we determined response thresholds for a 20 ms characteristic frequency (CF) pure tone (the probe), and then presented it in conjunction with another tone (the masker) that was varied in intensity, duration, and frequency; we also systematically varied the masker-to-probe delay. Probe response thresholds increased and response magnitudes decreased when a masker was presented. The forward suppression effects were greater when masker level and masker duration were increased, when the masker frequency approached the MNTB unit’s characteristic frequency, and as the masker-to-probe delay was shortened. Probe threshold shifts showed an exponential decay as the masker-to-probe delay increased.

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Section: Discussionmentioning

confidence: 89%

Forward masking in the medial nucleus of the trapezoid body of the rat

Gao

Berrebi

2015

Brain Struct Funct

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“…Ketamine can potentiate inhibition by acting as a GABA‐A receptor agonist (Irifune et al ., ), and it can therefore lengthen neuronal recovery times. In fact, it has been reported that ketamine reduces the range of modulation frequencies that can be tracked by neurons in the mouse superior paraolivary nucleus (Felix et al ., ). Future studies in the bat cortex need to assess whether recovery times measured in awake bats are shorter than those described here (i.e., 80 ms).…”

Section: Discussionmentioning

confidence: 97%

Processing of temporally patterned sounds in the auditory cortex of Seba's short‐tailed bat,Carollia perspicillata

Martin

García‐Rosales

Beetz

et al. 2017

Eur J of Neuroscience

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This article presents a characterization of cortical responses to artificial and natural temporally patterned sounds in the bat species Carollia perspicillata, a species that produces vocalizations at rates above 50 Hz. Multi-unit activity was recorded in three different experiments. In the first experiment, amplitude-modulated (AM) pure tones were used as stimuli to drive auditory cortex (AC) units. AC units of both ketamine-anesthetized and awake bats could lock their spikes to every cycle of the stimulus modulation envelope, but only if the modulation frequency was below 22 Hz. In the second experiment, two identical communication syllables were presented at variable intervals. Suppressed responses to the lagging syllable were observed, unless the second syllable followed the first one with a delay of at least 80 ms (i.e., 12.5 Hz repetition rate). In the third experiment, natural distress vocalization sequences were used as stimuli to drive AC units. Distress sequences produced by C. perspicillata contain bouts of syllables repeated at intervals of ~60 ms (16 Hz). Within each bout, syllables are repeated at intervals as short as 14 ms (~71 Hz). Cortical units could follow the slow temporal modulation flow produced by the occurrence of multisyllabic bouts, but not the fast acoustic flow created by rapid syllable repetition within the bouts. Taken together, our results indicate that even in fast vocalizing animals, such as bats, cortical neurons can only track the temporal structure of acoustic streams modulated at frequencies lower than 22 Hz.

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“…Such effects may be achieved if inhibitory interneurons are considered in the network (Oliver and Morest 1984; Malmierca et al 2009). For example, a timed disinhibition mediated by the SPON would enhance the IC SAM response up to the MF limit of SPON neurons (Kuwada and Batra 1999; Kadner and Berrebi 2008; Felix et al 2012). In this scenario, abolishing the SPON input would unmask a potentially tonic inhibition from interneurons, which would smear the synchronization of the response without substantially affecting the overall spiking activity.…”

Section: Discussionmentioning

confidence: 99%

The superior paraolivary nucleus shapes temporal response properties of neurons in the inferior colliculus

2014

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The mammalian superior paraolivary nucleus (SPON) is a major source of GABAergic inhibition to neurons in the inferior colliculus (IC), a well-studied midbrain nucleus that is the site of convergence and integration for the majority ascending auditory pathways en route to the cortex. Neurons in the SPON and IC exhibit highly precise responses to temporal sound features, which are important perceptual cues for naturally occurring sounds. To determine how inhibitory input from the SPON contributes to the encoding of temporal information in the IC, a reversible inactivation procedure was conducted to silence SPON neurons while recording responses to amplitude-modulated tones and silent gaps between tones in the IC. The results show that SPON-derived inhibition shapes responses of onset and sustained units in the IC via different mechanisms. Onset neurons appear to be driven primarily by excitatory inputs and their responses are shaped indirectly by SPON-derived inhibition, whereas sustained neurons are heavily influenced directly by transient offset inhibition from the SPON. The findings also demonstrate that a more complete dissection of temporal processing pathways is critical for understanding how biologically important sounds are encoded by the brain.

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Effects of ketamine on response properties of neurons in the superior paraolivary nucleus of the mouse

Cited by 16 publications

References 77 publications

Forward masking in the medial nucleus of the trapezoid body of the rat

Forward masking in the medial nucleus of the trapezoid body of the rat

Processing of temporally patterned sounds in the auditory cortex of Seba's short‐tailed bat,Carollia perspicillata

The superior paraolivary nucleus shapes temporal response properties of neurons in the inferior colliculus

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