NLRP6 expressed in astrocytes aggravates neurons injury after OGD/R through activating the inflammasome and inducing pyroptosis

Zhang, Jinyan; Jiang, Ning; Zhang, Luyu; Meng, Changchang; Zhao, Jing; Wu, Jiangling

doi:10.1016/j.intimp.2019.106183

Cited by 38 publications

(27 citation statements)

References 30 publications

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“…For example, in a rat model of middle cerebral artery occlusion/reperfusion, an upregulated brain expression of Nlrp6 aggravates cerebral ischaemic and reperfusion injury and worsens neurological functions, indicating a potential neuroprotective role of NLRP6 59 . In this regard, a recent in vitro study showed that upon oxygen–glucose deprivation, NLRP6 inflammasome assembly in astrocytes induces the production of the pro‐inflammatory cytokines IL‐1β and IL‐8, coupled with promotion of pyroptosis 60 . Likewise in another mouse model of intracerebral haemorrhage, Nlrp6 downregulation targeted by a microRNA miR‐331‐3p dampens the inflammatory responses and restores the neurological function after cerebral haemorrhage 25 .…”

Section: Nlrp6 Inflammasome Assembly Regulation and Effector Functionmentioning

confidence: 99%

The NLRP6 inflammasome

2020

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Section: Nlrp6 Inflammasome Assembly Regulation and Effector Functionmentioning

confidence: 99%

The NLRP6 inflammasome

2020

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“…After the development of these vesicles, pores are formed in the cell membrane through which the intracellular contents flow out [12]. The typical pyroptotic pathway is sparked by the activation of nucleotide-binding domain leucine-rich repeats family protein 3 (NLRP3) inflammasomes as well as the associated inflammatory response [13,14]. Several reports have verified that pyroptosis plays a critical role in tumorigenesis and cancer treatment [15][16][17][18][19].…”

Section: Introductionmentioning

confidence: 99%

A novel pyroptosis-related lncRNA signature for prognostic prediction in patients with lung adenocarcinoma

et al. 2021

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Lung adenocarcinoma (LUAD) has been the major cause of tumor-associated mortality in recent years and has a poor prognosis. Pyroptosis is regulated via the activation of inflammasomes and participates in tumorigenesis. However, the effects of pyroptosis-related lncRNAs (PRlncRNAs) on LUAD have not yet been completely elucidated. Therefore, we attempted to systematically explore patterns of cell pyroptosis to establish a novel signature for predicting LUAD survival. Based on TCGA database, we set up a prognostic model by incorporating PRlncRNAs with differential expression using Cox regression and LASSO regression. Kaplan-Meier analysis was conducted to compare the survival of LUAD patients. We further simplified the risk model and created a nomogram to enhance the prediction of LUAD prognosis. Altogether, 84 PRlncRNAs with differential expression were discovered. Subsequently, a new risk model was constructed based on five PRlncRNAs, GSEC, FAM83A-AS1, AL606489.1, AL034397.3 and AC010980.2. The proposed signature exhibited good performance in prognostic prediction and was related to immunocyte infiltration. The nomogram exactly forecasted the overall survival of patients and had excellent clinical utility. In the present study, the five-lncRNA prognostic risk signature and nomogram are trustworthy and effective indicators for predicting the prognosis of LUAD.

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“…Moreover, Map2k7 heterozygous mice showed insufficient prefrontal cortex-dependent working memory [44,46], consistent with the learning and memory impairment in Brpf1 mutant mice [19]; Nlrp6 is part of Nlrp6 inflammasome and plays a crucial role in innate immunity and inflammation. Nlrp6 could induce apoptosis to regulate the survival of neurons [47].Interestingly, study found that the space exploration ability and associative learning of Nlrp6 -/male mice were weakened [48]. We validated that Map2k7 and Nlrp6 were significantly decreased upon Brpf1 knockdown ( Figure 5C).…”

Section: Gabaergic Interneuronsmentioning

confidence: 55%

Deficiency of intellectual disability-related geneBrpf1reduced inhibitory neurotransmission andMap2k7expression in GABAergic interneurons

You

Cao

Xian

et al. 2021

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Intellectual disability is closely related to impaired GABA neurotransmission. Brpf1 was specifically expressed in medial ganglionic eminence (MGE), a developmental niche of GABAergic interneurons, and patients with BRPF1 mutations were mentally retarded. To test its role in development and function of MGE-derived GABAergic interneurons, we performed immunofluorescence staining, whole-cell patch-clamp, MGE transplantation and mRNA-Seq to understand its effect on neuronal differentiation, dendritic morphology, electrophysiology, migration and gene regulation, using mouse MGE-derived GABAergic interneurons infected with AAV-shBrpf1. We found a decreasing trend on parvalbumin+ interneuron differentiation. Moreover, increased firing threshold, decreased number of evoked APs, and a reduced amplitude of mIPSCs were observed before any significant change of MAP2+ dendritic morphology and in vivo migration appeared. Finally, mRNA-Seq analysis revealed that genes related to neurodevelopment and synaptic transmission such as Map2k7 were dysregulated. Our results demonstrated a key role of Brpf1 in inhibitory neurotransmission and related gene expression of GABAergic interneurons.

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NLRP6 expressed in astrocytes aggravates neurons injury after OGD/R through activating the inflammasome and inducing pyroptosis

Cited by 38 publications

References 30 publications

The NLRP6 inflammasome

The NLRP6 inflammasome

A novel pyroptosis-related lncRNA signature for prognostic prediction in patients with lung adenocarcinoma

Deficiency of intellectual disability-related geneBrpf1reduced inhibitory neurotransmission andMap2k7expression in GABAergic interneurons

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