Nizatidine enhances salivary secretion in patients with dry mouth

Histamine modulates salivary secretion and diminishes the progression of periodontal disease in rat experimental periodontitis

“…In this regard, histamine H1 receptor antagonists prescribed for allergic reactions are reported to cause xerostomia (dry mouth), which is a pathological condition characterized by decreased salivary secretion [50]. On the other hand, other studies demonstrated that H2 receptor antagonists enhanced salivary secretion [51], while preventing periodontitis when locally administered [52]. In our study, a secretory effect of histamine in the control group (non-periodontitis) was not observed, except for a very slight increase at the lowest methacholine concentration, suggesting that the preventive effect of histamine on periodontitis-induced salivary secretion dysfunction is preferentially due to its capacity to reduce the apoptotic response and to enhance the proliferative capacity of SMG.…”

The effect of fluoxetine on the structure of adult rat parotid glands and the possible role of pilocarpine with nizatidine

“…It has been reported that nizatidine has a saliva stimulatory effect in addition to its effects of accelerating gastric juice release and increasing the pressure of the lower esophageal sphincter, which suppress the onset of gastroesophageal reflux disease [23]. The mechanism by which nizatidine induces these effects has still not been completely clarified [23].…”

Xerostomia: An Update of Causes and Treatments

“…Other drugs that have been put forward include drug with mucolytic properties such us bromhexine improved salivary secretion in patients with SS [86,87]. Nizatidine, an H2 receptor antagonist alone or in combination with cisapride, showed a significant increase in salivary secretions of dry mouth patients [88,89]. In addition, other drugs, such as neostigmine, distigmine, yohimbine, nicotinic, and malic acid have also been attributed positive effects in the treatment of xerostomia [3].…”