Nitrosamine formation from the reaction of methamphetamine with gaseous nitrous acid

Mayer, Alexandra; Rindelaub, Joel D.; Miskelly, Gordon M.

doi:10.1002/dta.3048

Cited by 7 publications

(8 citation statements)

References 19 publications

(43 reference statements)

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“…One of the questions associated with clandestine drug production in houses relates to their fate and/or their degradation following their deposition on surfaces inside dwellings. Mayer et al presented a proof‐of‐concept study that investigated the interaction of methamphetamine with the common gaseous indoor oxidant nitrous acid and found that the detection of the suspected carcinogenic and mutagenic N ‐nitrosomethamphetamine could potentially present a risk to public health in properties contaminated with methamphetamine 12 . A retrospective study involving the analysis of methamphetamine profiles obtained from the Australian Federal Police was carried out by Popovic and colleagues who explored the feasibility of using drug profiles for the understanding of drug markets at a strategic and operational level.…”

Section: Beyond the Traditionalmentioning

confidence: 99%

Addressing the challenges in forensic drug chemistry II

Brandt

Collins

2022

Drug Testing and Analysis

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Section: Beyond the Traditionalmentioning

confidence: 99%

Addressing the challenges in forensic drug chemistry II

Brandt

Collins

2022

Drug Testing and Analysis

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Section: Introductionmentioning

confidence: 99%

“…In the cosmetics industry, nitrosamines were reported in hair dyes, nail polish, and other personal care products. Nitrosamines have also been reported in pharmaceuticals, particularly in products that contain nitrosatable compounds 2 7 8 9 . Recent reports have shown that nitrosamine impurities have been found in several drugs, including the anti-hypertensive drug valsartan and metformin an anti-diabetic drug widely used by the public 10 11 12 .…”

Section: Introductionmentioning

confidence: 99%

“…Adequate testing and extensive research are crucial for producing and distributing herbal medicines to the general population. ed in pharmaceuticals, particularly in products that contain nitrosatable compounds [2,[7][8][9]. Recent reports have shown that nitrosamine impurities have been found in several drugs, including the anti-hypertensive drug valsartan and metformin an anti-diabetic drug widely used by the public [10][11][12].…”

Section: Introductionmentioning

confidence: 99%

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Nitrosamine Impurities in Herbal Formulations: A Review of Risks and Mitigation Strategies

et al. 2023

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Nitrosamines are a class of chemical compounds that have been found to be impurities in a variety of pharmaceutical products. These impurities have raised concerns due to their potential carcinogenic effects. Recent studies have identified nitrosamines as impurities in a number of pharmaceutical products including angiotensin II receptor blockers (ARBs) and proton pump inhibitors (PPIs). The presence of nitrosamines in these products has led to recalls and market withdrawals. In addition to pharmaceuticals, nitrosamines have also been found in some herbal medicines particularly those containing traditional Chinese medicinal ingredients. The presence of nitrosamines in herbal formulations poses a significant risk to public health and highlights the need for quality control and regulations in the herbal drug industry. The present review article aims to discuss nitrosamine impurities (NMI) prominent causes, risks and scientific strategies for preventing NMI in herbal formulations. The primary objective of this study is to examine the origins of nitrosamine contamination in herbal formulations, the risks associated with these contaminants, and the methods for reducing them. The significance of thorough testing and examination before releasing herbal products to the public is also emphasized. In conclusion, the presence of nitrosamines is not limited to pharmaceutical products and poses a significant threat to the safety of herbal drugs as well. Adequate testing and extensive research are crucial for producing and distributing herbal medicines to the general population.

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“…Moreover, HONO is an important indoor air pollutant, 6 which, upon entering the human body, can react with secondary amines to produce carcinogenic nitrosamines, posing a threat to human health. 7 Despite extensive research on HONO's impact on air quality, significant uncertainties remain in quantifying its formation and tracing its origins to nitrogen sources.…”

Section: ■ Introductionmentioning

confidence: 99%

Quantifying the Nitrogen Sources and Secondary Formation of Ambient HONO with a Stable Isotopic Method

Zong,

Wang,

Chai

et al. 2023

Environ. Sci. Technol.

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Nitrous acid (HONO) is a reactive gas that plays an important role in atmospheric chemistry. However, accurately quantifying its direct emissions and secondary formation in the atmosphere as well as attributing it to specific nitrogen sources remains a significant challenge. In this study, we developed a novel method using stable nitrogen and oxygen isotopes (δ15N; δ18O) for apportioning ambient HONO in an urban area in North China. The results show that secondary formation was the dominant HONO formation processes during both day and night, with the NO2 heterogeneous reaction contributing 59.0 ± 14.6% in daytime and 64.4 ± 10.8% at nighttime. A Bayesian simulation demonstrated that the average contributions of coal combustion, biomass burning, vehicle exhaust, and soil emissions to HONO were 22.2 ± 13.1, 26.0 ± 5.7, 28.6 ± 6.7, and 23.2 ± 8.1%, respectively. We propose that the isotopic method presents a promising approach for identifying nitrogen sources and the secondary formation of HONO, which could contribute to mitigating HONO and its adverse effects on air quality.

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Nitrosamine formation from the reaction of methamphetamine with gaseous nitrous acid

Cited by 7 publications

References 19 publications

Addressing the challenges in forensic drug chemistry II

Addressing the challenges in forensic drug chemistry II

Nitrosamine Impurities in Herbal Formulations: A Review of Risks and Mitigation Strategies

Quantifying the Nitrogen Sources and Secondary Formation of Ambient HONO with a Stable Isotopic Method

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