Nitroprusside and metal nitroprusside nano analogues for cancer therapy

Abstract

Sodium nitroprusside (SNP), U.S approved drug has been used in clinical emergency as a hypertensive drug for more than a decade. It is well established for its various biomedical applications such as angiogenesis, wound healing, neurological disorders including anti-microbial applications etc. Apart from that, SNP have been considered as excellent biomedical materials for its use as anti-cancer agent because of its behavior as NO-donor. Recent reports suggest that incorporation of metals in SNP/encapsulation of SNP in metal nanoparticles (metal nitroprusside analogues) shows better therapeutic anti-cancer activity. Although there are numerous reports available regarding the biological applications of SNP and metal-based SNP analogue nanoparticles, unfortunately there is not a single comprehensive review which highlights the anti-cancer activity of SNP and its derivative metal analogues in detail along with the future perspective. To this end, the present review article focuses the recent development of anti-cancer activity of SNP and metal-based SNP analogues, their plausible mechanism of action, current status. Furthermore, the future perspectives and challenges of these biomedical materials are also discussed. Overall, this review article represents a new perspective in the area of cancer nanomedicine that will attract a wider spectrum of scientific community.

Copper nitroprusside analogue nanoparticles against melanoma: detailed in vitro and in vivo investigation

“…11,12 Very recently, metal nanomedicines have been investigated for the treatment of several diseases, especially cancers. 13–18 Among various metals, copper-based nanoparticles have attracted considerable attention in several interdisciplinary (agriculture, industry and environmental applications) and biomedical (anti-bacterial, anti-viral, cancer, wound healing, drug delivery, etc .) applications due to their distinct physiochemical characteristics.…”