ROS mediated Cu[Fe(CN)5NO] nanoparticles for triple negative breast cancer: A detailed study in preclinical mouse model

Copper nitroprusside analogue nanoparticles against melanoma: detailed in vitro and in vivo investigation

“…The detailed synthesis and characterization of CuNPANP have been reported in our recently published paper. 13 In the present study, we again synthesized CuNPANP via the interaction of copper sulfate and sodium nitroprusside (SNP) under stirring at room temperature. The newly synthesized CuNPANP were characterized by UV-VIS spectroscopy, XRD, TEM, SEM, XPS, etc ., and the results are presented in Fig.…”

“…11,12 Very recently, metal nanomedicines have been investigated for the treatment of several diseases, especially cancers. 13–18 Among various metals, copper-based nanoparticles have attracted considerable attention in several interdisciplinary (agriculture, industry and environmental applications) and biomedical (anti-bacterial, anti-viral, cancer, wound healing, drug delivery, etc .) applications due to their distinct physiochemical characteristics.…”

“…applications due to their distinct physiochemical characteristics. 13,19–21 Apart from this, copper has been used as a drug supplement to an anti-alcoholism drug, disulfiram (FDA-approved), for treating cancers in clinical trials. 22,23 Therefore, copper (Cu) and Cu-based nanomedicines have gained significant interest in the field of cancer biology as it is least explored even they have possible opportunity.…”

“…24 Various investigators including our group all over the world are investigating the anti-cancer properties of copper-based nanomedicines. 13,25–28…”

“…To this, our group investigated the anti-cancer properties of CuNPANP in triple-negative breast cancer. 13 These nanoparticles themselves possess anti-cancer activities without any anti-neoplastic agents. Melanoma arises as a global concern because of the unmet medical challenges associated with conventional therapeutics.…”