Nitrogen-doped carbon-ZnO heterojunction derived from ZIF-8: a photocatalytic antibacterial strategy for scaffold

Shuai, Cijun; Yuan, Xun; Shuai, Yang; Qian, Guowen; Yao, Jia Mei; Xu, Wendi; Peng, Shuping; Yang, Wenjing

doi:10.1016/j.mtnano.2022.100210

Cited by 31 publications

(18 citation statements)

References 55 publications

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“…Cell viability is also an important indicator for evaluating the cytocompatibility of the scaffold [ 38 ]. To investigate the cells viability induced by the PLLA, PLLA/Fe 3 O 4 and PLLA/Fe 3 O 4 @SiO 2 scaffolds, the cells were strained with calcein AM.…”

Section: Resultsmentioning

confidence: 99%

Construction of magnetic nanochains to achieve magnetic energy coupling in scaffold

Shuai

Chen

et al. 2022

Biomater Res

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Background Fe3O4 nanoparticles are highly desired for constructing endogenous magnetic microenvironment in scaffold to accelerate bone regeneration due to their superior magnetism. However, their random arrangement easily leads to mutual consumption of magnetic poles, thereby weakening the magnetic stimulation effect. Methods In this study, magnetic nanochains are synthesized by magnetic-field-guided interface co-assembly of Fe3O4 nanoparticles. In detail, multiple Fe3O4 nanoparticles are aligned along the direction of magnetic force lines and are connected in series to form nanochain structures under an external magnetic field. Subsequently, the nanochain structures are covered and fixed by depositing a thin layer of silica (SiO2), and consequently forming linear magnetic nanochains (Fe3O4@SiO2). The Fe3O4@SiO2 nanochains are then incorporated into poly l-lactic acid (PLLA) scaffold prepared by selective laser sintering technology. Results The results show that the Fe3O4@SiO2 nanochains with unique core–shell structure are successfully constructed. Meanwhile, the orderly assembly of nanoparticles in the Fe3O4@SiO2 nanochains enable to form magnetic energy coupling and obtain a highly magnetic micro-field. The in vitro tests indicate that the PLLA/Fe3O4@SiO2 scaffolds exhibit superior capacity in enhancing cell activity, improving osteogenesis-related gene expressions, and inducing cell mineralization compared with PLLA and PLLA/Fe3O4 scaffolds. Conclusion In short, the Fe3O4@SiO2 nanochains endow scaffolds with good magnetism and cytocompatibility, which have great potential in accelerating bone repair.

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Section: Resultsmentioning

confidence: 99%

Construction of magnetic nanochains to achieve magnetic energy coupling in scaffold

Shuai

Chen

et al. 2022

Biomater Res

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“…40 In addition, it also involves reducing the band gap by doping (non-metal, metal elements, etc. ), [41][42][43] recombination (metal, non-metal, etc. ), [44][45][46] hybridization (MOFs, UCNPs, etc.…”

Section: Light-triggered Therapymentioning

confidence: 99%

“…A great deal of research indicated that compared with traditional antibiotics, visible light-responsive photocatalytic materials could eliminate infection and inflammation in a short time, with better controllability as well as less adverse reactions, which were less likely to induce drug resistance. 41 In other words, the development of photocatalytic antibacterial materials is an effective strategy to decrease the misuse of antibiotics.…”

Section: Design and Biomedical Applications Of Single Exogenous Stimu...mentioning

confidence: 99%

Research progress of stimuli-responsive ZnO-based nanomaterials in biomedical applications

Weng

Gao

et al. 2023

Biomater. Sci.

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“…15,17 Meanwhile, it also has many advantages for antibacterial applications, such as minimal invasiveness, deep tissue penetration, and no drug resistance. 18,19 Therefore, combining photodynamic therapy with photothermal treatment will facilitate a significant synergistic antibacterial effect of photoresponsive nanoparticles. Constructing nanocomposites by assembling different photoresponsive nanoparticles is a prospective method to simultaneously achieve photothermal/photodynamic functions.…”

Section: Introductionmentioning

confidence: 99%

“…Currently, many strategies, including preventing bacterial adhesion, destroying biofilm integrity, enhancing bacterial membrane permeability, and so on, have been developed to enhance the available concentration of ROS in bacteria. − Among them, photothermal treatment is an effective method against both biofilms and membranes because high temperature can not only destroy the biofilm structure but also enhance membrane permeability. , Meanwhile, it also has many advantages for antibacterial applications, such as minimal invasiveness, deep tissue penetration, and no drug resistance. , Therefore, combining photodynamic therapy with photothermal treatment will facilitate a significant synergistic antibacterial effect of photoresponsive nanoparticles.…”

Section: Introductionmentioning

confidence: 99%

Photothermal and Photodynamic Effects of g-C₃N₄ Nanosheet/Bi₂S₃ Nanorod Composites with Antibacterial Activity for Tracheal Injury Repair

Qian

Wen

Shuai

et al. 2022

ACS Appl. Nano Mater.

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Photodynamic antimicrobial therapy via producing ROS based on light-responsive nanoparticles has attracted worldwide attention because of the high selectivity and low side effects. However, biofilms and bacterial membranes provide a natural barrier to prevent the penetration of ROS, which impairs the photodynamic antibacterial efficiency of nanoparticles. Photothermal therapy is an effective strategy against biofilms and bacterial membranes because high temperature can destroy the biofilm structure and enhance the membrane permeability. Herein, Bi2S3 nanorods were anchored on the surface of zinc-doped g-C3N4 (ZnCN) nanosheets to construct a ZnCN-Bi2S3 nanocomposite; then, it was incorporated into poly-l-lactic acid and prepared into scaffolds by the selective laser sintering technology. Bi2S3 nanorods not only endowed the scaffold with an excellent photothermal property but also strengthened the photodynamic effect of ZnCN nanosheets after forming the nanocomposite. The results showed that this nanocomposite had a lower recombination rate of photogenerated electron–hole pairs and produced higher photocurrent compared to those of the g-C3N4 nanosheets and Bi2S3 nanorods. The scaffold destroyed the biofilm and elevated the bacterial membrane permeability significantly and finally achieved 98.5% antibacterial rate for Staphylococcus aureus and 96.3% antibacterial rate for Pseudomonas aeruginosa. Encouragingly, the scaffold could also promote chondrogenic differentiation because of the continuous release of Zn ions. The scaffold containing ZnCN-Bi2S3 nanocomposites possessed excellent antimicrobial and cartilage regeneration functions, which displayed great potential in treating tracheal injuries.

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Nitrogen-doped carbon-ZnO heterojunction derived from ZIF-8: a photocatalytic antibacterial strategy for scaffold

Cited by 31 publications

References 55 publications

Construction of magnetic nanochains to achieve magnetic energy coupling in scaffold

Construction of magnetic nanochains to achieve magnetic energy coupling in scaffold

Research progress of stimuli-responsive ZnO-based nanomaterials in biomedical applications

Photothermal and Photodynamic Effects of g-C₃N₄ Nanosheet/Bi₂S₃ Nanorod Composites with Antibacterial Activity for Tracheal Injury Repair

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Nitrogen-doped carbon-ZnO heterojunction derived from ZIF-8: a photocatalytic antibacterial strategy for scaffold

Cited by 31 publications

References 55 publications

Construction of magnetic nanochains to achieve magnetic energy coupling in scaffold

Construction of magnetic nanochains to achieve magnetic energy coupling in scaffold

Research progress of stimuli-responsive ZnO-based nanomaterials in biomedical applications

Photothermal and Photodynamic Effects of g-C3N4 Nanosheet/Bi2S3 Nanorod Composites with Antibacterial Activity for Tracheal Injury Repair

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Product

Resources

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Photothermal and Photodynamic Effects of g-C₃N₄ Nanosheet/Bi₂S₃ Nanorod Composites with Antibacterial Activity for Tracheal Injury Repair