Nitrogen doped carbon quantum dots demonstrate no toxicity under<i>in vitro</i>conditions in a cervical cell line and<i>in vivo</i>in Swiss albino mice

Singh, Vimal; Kashyap, Sonu; Yadav, Umakant; Srivastava, Anchal; Singh, Ajay Vikram; Singh, Radhey M.; Singh, Santosh Kumar; Saxena, Preeti S.

doi:10.1039/c8tx00260f

Cited by 43 publications

(25 citation statements)

References 39 publications

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“…In the recent scenario, due to their comprehensive assortment of implementations in the world of biomedicine, nanomaterials have emerged as potent tools for clinicians and researchers in different biomedical and allied fields of human life [16,17,18]. Nanomaterials possess notable virtues, such as high reactivity, large surface-to-mass ratio, and ultra-small size making them highly useful in biomedical applications [19,20].…”

Section: Introductionmentioning

confidence: 99%

In Vivo Biocompatibility of Electrospun Biodegradable Dual Carrier (Antibiotic + Growth Factor) in a Mouse Model—Implications for Rapid Wound Healing

Dwivedi

Pandey

et al. 2019

Pharmaceutics

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Tissue engineering technologies involving growth factors have produced one of the most advanced generations of diabetic wound healing solutions. Using this approach, a nanocomposite carrier was designed using Poly(d,l-lactide-co-glycolide) (PLGA)/Gelatin polymer solutions for the simultaneous release of recombinant human epidermal growth factor (rhEGF) and gentamicin sulfate at the wound site to hasten the process of diabetic wound healing and inactivation of bacterial growth. The physicochemical characterization of the fabricated scaffolds was carried out using scanning electron microscopy (SEM) and X-ay diffraction (XRD). The scaffolds were analyzed for thermal stability using thermogravimetric analysis and differential scanning calorimetry. The porosity, biodegradability, and swelling behavior of the scaffolds was also evaluated. Encapsulation efficiency, drug loading capacity, and in vitro drug release were also investigated. Further, the bacterial inhibition percentage and detailed in vivo biocompatibility for wound healing efficiency was performed on diabetic C57BL6 mice with dorsal wounds. The scaffolds exhibited excellent wound healing and continuous proliferation of cells for 12 days. These results support the applicability of such systems in rapid healing of diabetic wounds and ulcers.

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Section: Introductionmentioning

confidence: 99%

In Vivo Biocompatibility of Electrospun Biodegradable Dual Carrier (Antibiotic + Growth Factor) in a Mouse Model—Implications for Rapid Wound Healing

Dwivedi

Pandey

et al. 2019

Pharmaceutics

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“…114 The molecular dynamic simulation, supported with experimental photothermal therapy, has shown the excellent application of these GNPs in nanomedicine for clearing biofilm and promoting the grown of fibroblast. 115,116 These biomineralized nanomaterials proved excellent imaging agents 117 and are drug carriers with enhanced bioavailability in vitro 118 and in vivo. 119 Modifying the GNPs with peptides is another way to enhance efficiency and safety.…”

Section: Inorganic Nanomedicinementioning

confidence: 99%

Nanomedicine-Based Therapeutics to Combat Acute Lung Injury

Bian¹,

Cai²,

Cui³

et al. 2021

IJN

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Acute lung injury (ALI) or its aggravated stage acute respiratory distress syndrome (ARDS) may lead to a life-threatening form of respiratory failure, resulting in high mortality of up to 30-40% in most studies. Although there have been decades of research since ALI was first described in 1967, the clinical therapeutic alternatives for ALI are still in a state of limited availability. Supportive treatment and mechanical ventilation still have priority. Despite some preclinical studies demonstrating the benefit of pharmacological interventions, none of these has been proved completely effective to date. Recent advances in nanotechnology may shed new light on the pharmacotherapy of ALI. Nanomedicine possesses targeting and synergistic therapeutic capability, thus boosting pharmaceutical efficacy and mitigating the side effects. Currently, a variety of nanomedicine with diverse frameworks and functional groups have been elaborately developed, in accordance with their lung targeting ability and the pathophysiology of ALI. The in-depth review of the current literature reveals that liposomes, polymers, inorganic materials, cell membranes, platelets, and other nanomedicine approaches have conferred attractive therapeutic benefits for ALI treatment. In this review, we explore the recent progress in the study of the nanomedicinebased therapy of ALI, presenting various nanomedical approaches, drug choices, therapeutic strategies, and outcomes, thereby providing insight into the trends.

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“…In 2019, Singh et al [ 220 ] systematically evaluated the in vivo and in vitro toxicity of N-CQDs. For the first time, an extensive assessment of the phenomena of in vitro cyto- and genotoxicity of CQDs was entailed, and an in-depth analysis of hematological, biochemical, and histopathological parameters in vivo was performed in Swiss albino mice.…”

Section: Pharmacokinetics Pharmacodynamics and Toxicitymentioning

confidence: 99%

You Don’t Learn That in School: An Updated Practical Guide to Carbon Quantum Dots

2021

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Carbon quantum dots (CQDs) have started to emerge as candidates for application in cell imaging, biosensing, and targeted drug delivery, amongst other research fields, due to their unique properties. Those applications are possible as the CQDs exhibit tunable fluorescence, biocompatibility, and a versatile surface. This review aims to summarize the recent development in the field of CQDs research, namely the latest synthesis progress concerning materials/methods, surface modifications, characterization methods, and purification techniques. Furthermore, this work will systematically explore the several applications CQDs have been subjected to, such as bioimaging, fluorescence sensing, and cancer/gene therapy. Finally, we will briefly discuss in the concluding section the present and future challenges, as well as future perspectives and views regarding the emerging paradigm that is the CQDs research field.

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Nitrogen doped carbon quantum dots demonstrate no toxicity underin vitroconditions in a cervical cell line andin vivoin Swiss albino mice

Abstract: Carbon quantum dots (CQDs) and their derivatives have potential applications in the field of biomedical imaging.

Cited by 43 publications

References 39 publications

In Vivo Biocompatibility of Electrospun Biodegradable Dual Carrier (Antibiotic + Growth Factor) in a Mouse Model—Implications for Rapid Wound Healing

In Vivo Biocompatibility of Electrospun Biodegradable Dual Carrier (Antibiotic + Growth Factor) in a Mouse Model—Implications for Rapid Wound Healing

Nanomedicine-Based Therapeutics to Combat Acute Lung Injury

You Don’t Learn That in School: An Updated Practical Guide to Carbon Quantum Dots

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