Nitrogen-doped carbon dots/curcumin nanocomposite for combined Photodynamic/photothermal dual-mode antibacterial therapy

Wen, Fangzhou; Li, Peiyuan; Meng, Hongrong; Yan, Hongjun; Huang, Xiaodong; Chen, Hao; Su, Wei

doi:10.1016/j.pdpdt.2022.103033

Cited by 23 publications

(10 citation statements)

References 23 publications

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“…It is considered that the structure of MB was changed in the synthesized MB-CPDs. By the hydrothermal processing, more defects and oxygen-containing functional groups might form on MB-CPDs, which provided more active sites and enhanced the interaction between MB-CPDs and oxygen. − In addition, the enhanced stability, prolonged triplet lifetime, and increased interaction time with oxygen could improve the yield of 1 O 2 . Moreover, the special electronic energy level structure of CDs could contribute to the formation of additional excited states under illumination, which further boost the efficiency of photooxygenation .…”

Section: Resultsmentioning

confidence: 99%

Methylene Blue-Doped Carbonized Polymer Dots: A Potent Photooxygenation Scavenger Targeting Alzheimer’s β-Amyloid

Lin,

Zhang,

Liu

et al. 2023

ACS Appl. Mater. Interfaces

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The abnormal aggregation of β-amyloid protein (Aβ) is one of the main pathological hallmarks of Alzheimer's disease (AD), and thus development of potent scavengers targeting Aβ is considered an effective strategy for AD treatment. Herein, photosensitizer-doped carbonized polymer dots (PS-CPDs) were synthesized by a one-step hydrothermal method using photosensitizer (PS) and o-phenylenediamine (oPD) as precursors, and furtherly applied to inhibit Aβ aggregation via photooxygenation. The inhibition efficiency of such PS-CPDs can be adjusted by varying the type of photosensitizer, and among them, methylene blue-doped carbonized polymer dots (MB-CPDs) showed the strongest photooxygenation inhibition capability. The results demonstrated that under 650 nm NIR light irradiation, MB-CPDs (2 μg/mL) produced reactive oxygen species (ROS) to efficiently inhibit Aβ fibrillization and disaggregate mature Aβ fibrils and increased the cultured cell viability from 50% to 83%. In vivo studies confirmed that MB-CPDs extended the lifespan of AD nematodes by 4 days. Notably, the inhibitory capability of MB-CPDs is much stronger than that of MB and previously reported carbonized polymer dots. This work indicated that potent photooxygenation carbon dots can be obtained by using a photosensitizer as one of the precursors, and the results have provided new insights into the design of potent photooxygenation carbon nanomaterials targeting Aβ in AD treatment.

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Section: Resultsmentioning

confidence: 99%

Methylene Blue-Doped Carbonized Polymer Dots: A Potent Photooxygenation Scavenger Targeting Alzheimer’s β-Amyloid

Lin,

Zhang,

Liu

et al. 2023

ACS Appl. Mater. Interfaces

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“…Intraperitoneal treatment with these CQDs significantly reduced mortality and protected against virus-induced hind-limb paralysis in EV71-infected mice in vivo experiments. [228] In another approach, Wen et al [162] Surface-decorated CQDs with curcumin to create photosensitive N-CQDs. These N-CQDs, when exposed to 405and 808-nm light irradiation, exhibited collaborative PTT and PDT effects, generating 1 O 2 and raising the solution temperature concurrently.…”

Section: Antibacterial Effect For Treating Inflammationmentioning

confidence: 99%

Fluorescent carbon quantum dots with controllable physicochemical properties fantastic for emerging applications: A review

You,

Zou,

Jiang

et al. 2024

Carbon Neutralization

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Carbon quantum dots (CQDs) have emerged as prominent contenders in the realm of luminescent nanomaterials over the past decade owing to their tunable optical properties, robust photostability, versatile surface functionalization and doping potential, low toxicity, and straightforward synthesis utilizing environmentally friendly precursors. In this review, we commence with a concise introduction, presenting both top‐down and bottom‐up strategies for the eco‐friendly synthesis of CQDs. Subsequently, we delve into a comprehensive examination of CQDs' structure and optical characteristics, encompassing their ultraviolet–visible absorption properties, surface confinement effects, and surface state emissions contributing to room‐temperature photoluminescence (PL). This review proceeds to elucidate recent advancements in modification strategies for CQDs, specifically focusing on surface oxidation, passivation, and the incorporation of heteroatoms. These strategies serve to afford control over the physicochemical properties, facilitating the enhancement of PL through the decoration of highly visible‐responsive CQDs. This enhancement is achieved by suppressing the nonradiative recombination of electron‐hole pairs, enabling red/blue shifts in CQDs for the generation of a full‐color emission spectrum, and regulating the band‐gap and surface states to broaden the photoabsorption range. Finally, we offer an overview of the most recent developments in the applications of fluorescent CQDs, emphasizing their utility in biomedicine, fluorescent sensors, lighting, and displays, as well as photocatalysis.

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“…Accordingly, CDs have been used as carriers to load curcumin for the construction of composite nanomaterials, enhance the solubility and bioavailability of curcumin, and promote its photodynamic antibacterial properties (figure 8). Su et al, discovered that CDs containing curcumin not only produce 1 O 2 but also possess certain formal conversion properties that enable photothermal/photodynamic combined antibacterial treatment [127,128]. Correspondingly, they synthesized NIR emissive curcumin carbon quantum dots (Cur-NRCQDs) with antibacterial and imaging effects by hydrothermal method.…”

Section: Cds Act As Auxiliary Antibacterial Agentmentioning

confidence: 99%

Synthesis, properties and mechanism of carbon dots-based nano-antibacterial materials

Zhu,

Peng,

Liang

et al. 2023

Biomed. Mater.

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Antibiotics play an important role in the treatment of diseases, but bacterial resistance caused by their widespread and unreasonable use has become an urgent problem in clinical treatment. With the rapid advancement of nanoscience and nanotechnology, the development of nanomedicine has been transformed into a new approach to the problem of bacterial resistance. As a new type of carbon-based nanomaterial, carbon dots (CDs) have attracted the interest of antibacterial researchers due to their ease of preparation, amphiphilicity, facile surface functionalization, and excellent optical properties, among other properties. This article reviewed the synthesis methods and properties of various CDs and their composites in order to highlight the advancements in the field of CDs-based antibacterial agents. Then we focused on the relationship between the principal properties of CDs and the antibacterial mechanism, including the following: (1) The physical damage caused by the small size, amphiphilicity, and surface charge of CDs. (2) Photogenerated electron transfer characteristics of CDs that produce reactive oxygen species (ROS) in themselves or in other compounds. The ability of ROS to oxidize can lead to the lipid peroxidation of cell membranes, as well as damage proteins and DNA. (3) The nanoenzyme properties of CDs can catalyze reactions that generate ROS. (4) Synergistic antibacterial effect of CDs and antibiotics or other nanocomposites. Finally, we look forward to the challenges that CDs-based nanocomposites face in practical antibacterial applications and propose corresponding solutions to further expand the application potential of nanomaterials in the treatment of infectious diseases, particularly drug-resistant bacterial infections.

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Nitrogen-doped carbon dots/curcumin nanocomposite for combined Photodynamic/photothermal dual-mode antibacterial therapy

Cited by 23 publications

References 23 publications

Methylene Blue-Doped Carbonized Polymer Dots: A Potent Photooxygenation Scavenger Targeting Alzheimer’s β-Amyloid

Methylene Blue-Doped Carbonized Polymer Dots: A Potent Photooxygenation Scavenger Targeting Alzheimer’s β-Amyloid

Fluorescent carbon quantum dots with controllable physicochemical properties fantastic for emerging applications: A review

Synthesis, properties and mechanism of carbon dots-based nano-antibacterial materials

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