Nitrogen dioxide and allergic asthma: starting to clarify an obscure association

Antó, JosepM.; Sunyer, Jordi

doi:10.1016/s0140-6736(95)90395-x

Cited by 21 publications

(11 citation statements)

References 7 publications

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“…15 29 On the other hand, children who have atopic pre-disposition have been suggested to be susceptible to environmental factors-such as air pollution and passive smoking. [30][31][32] The present findings also suggest that children with asthma or wheeze and children with higher IgE concentrations were susceptible to air pollution and exposure to ETS. No significant difference in serum hyaluronate concentration, however, was found between children who had asthma or wheeze and children without these symptoms, leaving the physiological significance of hyaluronate concentrations unclear.…”

Section: Discussionsupporting

confidence: 64%

Effect of air pollution and environmental tobacco smoke on serum hyaluronate concentrations in school children

Fuji

Shima²,

Ando³

et al. 2002

Occup Environ Med

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Objectives: To evaluate serum hyaluronate concentrations relative to air pollution, environmental tobacco smoke (ETS), and respiratory health in Japanese school children. Methods: Respiratory symptoms and serum IgE concentrations were examined in 1037 school children living in four communities in Japan with differing levels of air pollution. Serum hyaluronate concentrations were assayed in 230 children, consisting of all the children who had symptoms of either asthma or wheeze (65 and 50 subjects, respectively) and normal controls adjusted for sex, school grade, and school without these symptoms (115 subjects). Results: Although serum hyaluronate concentrations did not differ for either asthma or wheeze, the concentrations were significantly higher in children living in communities with higher levels of air pollution. Children with asthma or wheeze and those with serum IgE concentrations of 250 IU/ml or above showed differences in hyaluronate concentrations that related to the degree of air pollution in the communities. In children with higher serum IgE concentrations, the hyaluronate concentrations among subjects exposed to ETS were significantly higher than among those without exposure to ETS. Conclusions:The present results suggest that serum hyaluronate concentration is related to the degree of air pollution and exposure to ETS. Children with asthma or wheeze and children with higher IgE concentrations are considered to be more susceptible to environmental factors.

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Section: Discussionsupporting

confidence: 64%

Effect of air pollution and environmental tobacco smoke on serum hyaluronate concentrations in school children

Fuji

Shima²,

Ando³

et al. 2002

Occup Environ Med

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“…There is speculation that air pollutants increase the permeability of the bronchial mucosa to antigens, thereby decreasing the threshold for the antigen exposure needed to produce sensitization, and increasing the incidence of allergic asthma and asthma symptoms (32). We found that children who were both exposed and sensitized to cat allergen had greater responses to ozone.…”

Section: Discussionmentioning

confidence: 71%

The Effect of Ozone on Inner-City Children with Asthma

Mortimer

Tager

Dockery

et al. 2000

Am J Respir Crit Care Med

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Within a cohort of 846 inner-city asthmatic children aged 4 to 9 yr, we looked for subgroups that were more susceptible to the effects of summer ozone. Daily diaries were compared with ambient ozone levels to evaluate effect modification by demographic and environmental characteristics. Children born > 3 wk prematurely or weighing < 5.5 lb. had greater declines in morning % peak expiratory flow rate (PEFR) (1.8% versus 0.3% per 15 ppb ozone, p < 0.05) and a higher incidence of morning symptoms (odds ratio = 1.42 versus 1.09 per 15 ppb ozone, p < 0.05) than did children who had been full-term infants of normal birthweight. Among children who had been of low birthweight (LBW) or had been premature infants, greater declines were seen among those whose reported baseline medication category was "no medication" (3.2% decline) or "steroids" (2.7%) as opposed to beta agonists or xanthines (0.8%) or cromolyn without steroids (0. 1%). Among the children who had been normal birthweight and full-term infants, the cromolyn without steroids group had the greatest declines in %PEFR (1.3%, versus < 0.5% in each of the other three groups). Nonatopic children also had greater responses to ozone. We conclude that among an asthmatic cohort, children who had had an LBW or a premature birth showed the greatest responses to ozone.

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“…30 Clinically, the eVects of NO 2 on healthy subjects have not been conclusively demonstrated although in asthmatic people they seem to have a more prominent role. 7 There are few studies which have analysed the relation between concentrations of NO 2 and emergency visits for asthma. 9 10 12 14 A smaller eVect from NO 2 was found in the Barcelona study 9 (an increase of over 2.8% in asthma visits for an increase of 10 µg/m 3 ) and NO 2 was also found to have a greater impact in winter than in summer.…”

Section: Ozonementioning

confidence: 99%

“…4 For nitrogen dioxide (NO 2 ), it has recently been shown that there is greater reactivity to the house dust mite in patients with mild asthma after exposure in habitual domestic concentrations 5 6 clarifying in part the obscure relation between this pollutant and allergic asthma. 7 Among epidemiological community based studies, ecological time series studies predominate; in these, the eVect of air pollution on diVerent indicators is related. The emergency visits for asthma are considered as an indicator of severity or poor control of the illness.…”

mentioning

confidence: 99%

Association between hospital emergency visits for asthma and air pollution in Valencia, Spain.

Tenías¹,

Ballester²,

Rivera³

1998

Occup Environ Med

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Nitrogen dioxide and allergic asthma: starting to clarify an obscure association

Cited by 21 publications

References 7 publications

Effect of air pollution and environmental tobacco smoke on serum hyaluronate concentrations in school children

Effect of air pollution and environmental tobacco smoke on serum hyaluronate concentrations in school children

The Effect of Ozone on Inner-City Children with Asthma

Association between hospital emergency visits for asthma and air pollution in Valencia, Spain.

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