Nitrile functionalized silver(I) N-heterocyclic carbene complexes: DFT calculations and antitumor studies

Hussaini, Sunusi Y.; Haque, Rosenani A.; Fatima, Tehreem; Agha, Taleb M.; Majid, A. M. S. Abdul; Abdallah, Hassan H.; Razali, Mohd. R.

doi:10.1007/s11243-018-0216-6

Cited by 13 publications

(6 citation statements)

References 34 publications

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“…According to reported methods [ 36 , 37 , 38 ], 1 mmol CPBI 0 , different molar n -C 5 H 11 Br ( Table 1 ), 10 mL MeCN, and moderate NaOH were added into the reaction flask. After refluxing for 24 h, the organic solvent was evaporated in vacuo.…”

Section: Methodsmentioning

confidence: 99%

Preparation of Large Conjugated Polybenzimidazole Fluorescent Materials and Their Application in Metal Ion Detection

et al. 2021

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A new type of conjugated polybenzimidazole (CPBI) was synthesized through a simple polycondensation reaction without metal catalysis, and N-alkylation modification was carried out to solve the problems of solubility and fluorescence properties. A series of nano-microsphere polymers CPBIn with large conjugation, good solubility, and strong fluorescence has been successfully used as “turn-off” fluorescent probes for the first time. The results show that, under suitable N-alkylation conditions, the obtained CPBIn can be used as a highly sensitive and selective fluorescent probe for the detection of Cu2+ and Zn2+ at the same time, and their detection limits are both nM levels. In addition, CPBI2 can be designed as an ultra-sensitive IMPLICATION logic gate at the molecular level, cyclically detecting Cu2+. With the test paper containing CPBI2, easy and quick on-site detection can be achieved. This research provides a new idea for the brief synthesis of multifunctional materials.

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Section: Methodsmentioning

confidence: 99%

Preparation of Large Conjugated Polybenzimidazole Fluorescent Materials and Their Application in Metal Ion Detection

et al. 2021

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“…Compound 42 (IC 50 = 7 ± 1.06 μM) was found to be the most potent and it carries a pentyl chain attached to the benzimidazole nitrogen. Cytotoxicities of these compounds increase as the alkyl chain length expands [64].…”

Section: Bis-benzimidazolium Silver Metal Complexesmentioning

confidence: 99%

The Anticancer Profile of Benzimidazolium Salts and Their Metal Complexes

Khan¹,

Mohsin²,

Aslam³

et al. 2022

Benzimidazole

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Cancer is the most lethal ailment throughout the world in the present era. The development of new anticancer remedies with minor unhealthful effects and an alternate mechanism is crucial. Benzimidazole is a distinguished heterocyclic compound and is now recognized as the privileged scaffold for new drug discovery. This chapter deals with the anticancer capability of benzimidazolium salts and their metal complexes. The benzimidazolium derivatives have been prepared by the introduction of aliphatic and aromatic groups at two nitrogen atoms of the benzimidazole ring. Other modifications include hybridization with other pharmacophores and the preparation of metal complexes. The potent derivatives presented in this review can serve as novel drug candidates against cancer.

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“…The complexes 75 a – c and 76 a – c where obtained in a moderate yield in the range of 64.04–72 % and 67–72 % respectively (Scheme 18). [56] …”

Section: Synthetic Strategiesmentioning

confidence: 99%

Coinage Metal N‐Heterocyclic Carbene Complexes: Recent Synthetic Strategies and Medicinal Applications

Nayak

Gaonkar

2021

ChemMedChem

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New weapons are constantly needed in the fight against cancer. The discovery of cisplatin as an anticancer drug prompted the search for new metal complexes. The successful history of cisplatin motivated chemists to develop a plethora of metal‐based molecules. Among them, metal‐N‐heterocyclic carbene (NHC) complexes have gained significant attention because of their suitable qualities for efficient drug design. The enhanced applications of coinage metal‐NHC complexes have encouraged a gradually increasing number of studies in the fields of medicinal chemistry that benefit from the fascinating chemical properties of these complexes. This review aims to present recent developments in synthetic strategies and medicinal applications of copper, silver and gold complexes supported by NHC ligands.

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Nitrile functionalized silver(I) N-heterocyclic carbene complexes: DFT calculations and antitumor studies

Cited by 13 publications

References 34 publications

Preparation of Large Conjugated Polybenzimidazole Fluorescent Materials and Their Application in Metal Ion Detection

Preparation of Large Conjugated Polybenzimidazole Fluorescent Materials and Their Application in Metal Ion Detection

The Anticancer Profile of Benzimidazolium Salts and Their Metal Complexes

Coinage Metal N‐Heterocyclic Carbene Complexes: Recent Synthetic Strategies and Medicinal Applications

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