Nitric Oxide Synthesis is Increased in Periodontitis

Matĕjka, M; Ulm, Christian; Partyka, L.; Ulm, Martin; Sinzinger, H.

doi:10.1007/978-1-4615-4793-8_61

Cited by 4 publications

(4 citation statements)

References 18 publications

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“…Nitric oxide is known to be an important inflammatory mediator, and is involved in the pathophysiology of several inflammatory disorders. An increase in NO production has been also demonstrated in periodontitis as its role in the inflammatory response of periodontal tissues has been suggested (Matejka et al , 1998, 1999; Lappin et al , 2000; Hirose et al , 2001; Kendall et al , 2001; Lohinai et al , 2001; Daghigh et al , 2002). These findings are consistent with the hypothesis suggesting that treatment with agents able to block the production of NO or its effects might be therapeutically valuable for periapical lesions (Lohinai et al , 1998; Paquette and Williams, 2000; Daghigh et al , 2002).…”

Section: Discussionmentioning

confidence: 98%

“…Treatment strategies against periodontal diseases have evolved with the aim of eliminating specific pathogens or suppressing destructive host response. Although the pathogenesis of the various forms of this disease is not completely understood, several factors are believed to play an important role, including inflammatory cytokines (McGee et al , 1998; Graves, 1999), PGE 2 (Offenbacher, 1996; Tsai et al , 1998; Kornman, 1999), nitric oxide (Matejka et al , 1999; Takeichi et al , 2000) and salivary immunoglobulin‐A (IgA) antibodies (Schenk et al , 1993). Moreover, many of the characteristics of periodontal diseases such as inflammation and attachment loss are associated with proteolytic events.…”

Section: Introductionmentioning

confidence: 99%

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Anti‐inflammatory effects of Lactobacillus brevis (CD2) on periodontal disease

et al. 2007

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Our results suggest that the anti-inflammatory effects of L. brevis could be attributed to the presence of AD which prevented nitric oxide generation. Our findings give further insights into the knowledge of the molecular basis of periodontitis and have a potential clinical significance, giving the experimental ground for a new innovative, simple and efficacious therapeutical approach of periodontal disease.

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Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Anti‐inflammatory effects of Lactobacillus brevis (CD2) on periodontal disease

et al. 2007

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“…NO is thought to have a role in the pathogenesis of inflammatory periodontal disease as it does in other inflammatory diseases. Enhanced production of NO has been demonstrated in periodontal disease [17,18], and LPS from Actinobacillus actinomycetemcomitans ‐induced significant production of NO in macrophages [19,20]. Moreover, gingival tissues from patients with periodontitis have higher levels of iNOS protein and mRNA than healthy tissue [21–24].…”

Section: Introductionmentioning

confidence: 99%

Nitric oxide production and inducible nitric oxide synthase expression induced byPrevotella nigrescenslipopolysaccharide

Kim

Choi

et al. 2005

FEMS Immunology &Amp; Medical Microbiology

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We have examined the effects of lipopolysaccharide (LPS) from Prevotella nigrescens, one of the causative agents of inflammatory periodontal disease and endodontic infections, on the production of nitric oxide (NO) and expression of inducible nitric oxide synthase (iNOS) in the murine macrophage cell line RAW264.7. We also attempted to throw light on the signaling mechanisms involved in P. nigrescens LPS-induced NO production. We found that P. nigrescens LPS can induce iNOS expression and stimulate the release of NO without additional stimuli and demonstrated an important role of the transcription factor NF-kappaB and microtubule polymerization in NO production. The production of NO required l-arginine and protein tyrosine kinase but not activation of protein kinase C. The ability of P. nigrescens LPS to promote the production of NO may be important in the pathogenesis of inflammatory periodontal disease and endodontic infections.

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“…Previous studies indicate the presence of iNOS in inflamed gingival tissue from adult periodontitis patients [16][17][18]. Recently, formation of reactive nitrogen species in gingival tissue was demonstrated in an animal model [19].…”

Section: Discussionmentioning

confidence: 98%

Immunolocalization of Inducible Nitric Oxide Synthase in Localized Juvenile Periodontitis Patients

Gašpirc¹,

Masera²,

Skalerić³

2002

Connective Tissue Research

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Localized juvenile periodontitis (LJP) is associated with a destruction of periodontal tissues and the presence of Actinobacillus actinomycetemcomitans (AA). Lipopolysaccharide (LPS) from AA was found to induce a significant macrophage production of nitric oxide (NO). Increased nitric oxide synthase (NOS) activity was found to be negatively correlated with the neutrophil chemotactic response. The aim of this study was to determine the occurrence and distribution of inducible NOS (iNOS) in human gingival tissue from LJP patients. The distribution of iNOS was assessed by monoclonal antibody against iNOS. Cellular markers (CD 3, CD 20, and CD 68) were used to determine the cellular origin of iNOS. The immunostaining revealed the appearance of iNOS in inflamed compared to noninflamed gingival tissues. Macrophages expressed high levels of iNOS that may cause some damage to the periodontal tissues. This study suggests that iNOS activity in macrophages may modify abnormalities of neutrophil function.

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Nitric Oxide Synthesis is Increased in Periodontitis

Cited by 4 publications

References 18 publications

Anti‐inflammatory effects of Lactobacillus brevis (CD2) on periodontal disease

Anti‐inflammatory effects of Lactobacillus brevis (CD2) on periodontal disease

Nitric oxide production and inducible nitric oxide synthase expression induced byPrevotella nigrescenslipopolysaccharide

Immunolocalization of Inducible Nitric Oxide Synthase in Localized Juvenile Periodontitis Patients

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