Anti‐inflammatory effects of <i>Lactobacillus brevis</i> (CD2) on periodontal disease

Riccia, DN Della; Bizzini, F.; Perilli, MG; Polimeni, Antonella; Trinchieri, Vito; Amicosante, Gianfranco; Cifone, Maria Grazia

doi:10.1111/j.1601-0825.2006.01291.x

Cited by 189 publications

(167 citation statements)

References 45 publications

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“…11 Lactobacilli had been shown to be the strongest inhibitor of AActinimycetemcomitans, P gingivalis and P intermedia, potent microorganisms responsible for periodontal destruction. 20 Probiotic microorganisms do not act exclusively by affecting the microbiota, but also protect the oral cavity through the promotion of a beneficial host response. They exert effects either by modulating immunological parameters, epithelial permeability and bacterial translocation, or by providing bioactive or regulatory metabolites.…”

Section: Discussionmentioning

confidence: 99%

Role of Probiotics on Oral Health - A Randomized, Double Blind, Placebo-Controlled Microbiological Study

Dhawan¹,

Dhawan²

2013

DENT

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The aim of this study was to investigate commercially available combined probiotic formulation for its effect on plaque, gingivitis and salivary Streptococcus mutans levels in subjects with chronic gingivitis. A total of 36 subjects were finally enrolled in a double blind placebo controlled randomized trial. Selected subjects were randomly divided in two groups; Group A (Control group) with 17 subjects, receiving placebo tablets twice daily and Group B (Probiotic group) with 19 subjects receiving probiotic tablets twice daily. The study consisted of two 2 weeks periods, a two week intervention period (T1-T2) and a two week post treatment period (T2-T3). Clinical parameters and bacterial counts of salivary Streptococcus mutans, were evaluated at the baseline (T1), at the completion (T2) of medication and 2 weeks after medication (T3). On comparative evaluation between the two groups, results indicated that Group-B (Probiotic group) exhibited statistically significant reduction in Plaque Index, Gingival index and Streptococcus mutans level than Group-A (Control group) over the entire span of the study. Our results indicated that probiotic could be useful in the improvement/ maintainance of oral health.

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Section: Discussionmentioning

confidence: 99%

Role of Probiotics on Oral Health - A Randomized, Double Blind, Placebo-Controlled Microbiological Study

Dhawan¹,

Dhawan²

2013

DENT

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“…However, there are some bacteria that can decrease pro-inflammatory molecules. For example, L. brevis CD2 decreases inflammatory markers in saliva from patients with periodontal disease, including prostaglandin E2 (PGE2) [60]. Also, it was reported that probiotics, specifically, L. reuteri ATCC PTA 5289 decreased in CGF levels of TNF-α and IL-1β in patients with chronic periodontitis [61].…”

Section: Probiotic Effect On Immune Responsesmentioning

confidence: 99%

“…The use of Lactobacillus delbruekii and Lactobacillus fermentum significantly reduced IL-6 concentration and expression of TNF-α and NFκB in colon of patients with ulcerative colitis [70]. L. brevis CD2 decreased IFN-γ levels in saliva [60]. L. reuteri ATCC PTA 5289 decreased in CGF levels of IL-17 in patients with chronic periodontitis [61].…”

Section: Probiotic Effect On Immune Responsesmentioning

confidence: 99%

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Probiotics and Periodontal Diseases

Morales¹,

Bravo²,

Bedoya³

et al. 2017

Insights Into Various Aspects of Oral Health

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Probiotics are defined as live microorganisms that, when administered in adequate amounts, confer a health benefit on the host. Probiotics have been used to directly modify the resident oral microbiome and proposed to modulate immune responses. In dentistry, probiotics have been employed as useful adjuncts for the reduction of caries development, suppressing oral Candida infection and controlling halitosis. Plaque-induced gingivitis is a gingival inflammation caused by the adherent bacterial biofilm around teeth. Gingivitis and periodontitis are considered to be a continuum of the same inflammatory process, although many gingivitis lesions do not progress to periodontitis. Periodontitis is an inflammatory process that affects the attachment structures of teeth. It constitutes a second cause of tooth loss worldwide. Conventional treatment modalities of periodontal disease include non-surgical and/or surgical management, with an emphasis on mechanical debridement. However, mechanical debridement as a sole therapy is not always effective to improve clinical parameters. A growing number of studies support probiotic therapy to prevent or treat gingivitis and periodontitis. Oral administration of probiotics is an effective adjunct in reducing pathogenic bacteria and improving clinical signs of disease. Probiotics may serve as adjunct or replacement therapy substitute antibiotics in managing human periodontal infections in future.

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“…The modulating effect of short-term intake of probiotics on the oral immune response is dose dependent [52]. An anti-inflammatory effect of Lactobacillus brevis, administered as lozenge to patients with chronic periodontitis, was shown by a significant decrease in the amount of nitrite/nitrate, prostaglandin E2 and matrix metalloproteinase in saliva [53]. Different microbial species show anti-inflammatory activity [46].…”

Section: Periodontal Diseasementioning

confidence: 99%

Lactobacilli for the Treatment of Oral Diseases

Hoffmann¹,

Daniels²

2017

J Prob Health

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Probiotics are defined as live microorganisms that beneficially affect the host. Probiotic bacteria have been used therapeutically for years to target gastrointestinal disease by rebalancing the complex microflora. Besides the gastrointestinal tract also the oral cavity is highly colonized by bacteria and many different bacterial species are part of the microbiota in the mouth, as it offers ideal conditions for bacteria with a stable temperature, moist surface with a relatively stable pH and regular supply of nutrients. By disturbing the balance of microorganisms in the oral cavity or by extensive accumulation of plaque, the ratio of pathogenic organisms can increase and lead to oral health problems. Probiotic bacteria, like lactobacilli, are a promising treatment strategy for oral diseases with a microbiological aetiology. Those include plaqueassociated diseases like dental caries, which is an infectious disease with microbial processes eroding and destroying the hard dental tissue or inflammation of periodontal tissue, namely gingivitis and the more severe periodontitis. Moreover, endodontic infections, and even fungal, viral and acute bacterial infections could be treated by a probiotic therapy. The interest of probiotics in the field of oral health is growing, although it is still in its infancy. The present review adresses criteria for the selection of probiotic lactobacilli strains. It encompasses existing evidence on the use of lactobacilli for caries, halitosis and candidiasis, as well as for periodontal disease like Gingivitis and periodontitis.

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Anti‐inflammatory effects of Lactobacillus brevis (CD2) on periodontal disease

Cited by 189 publications

References 45 publications

Role of Probiotics on Oral Health - A Randomized, Double Blind, Placebo-Controlled Microbiological Study

Role of Probiotics on Oral Health - A Randomized, Double Blind, Placebo-Controlled Microbiological Study

Probiotics and Periodontal Diseases

Lactobacilli for the Treatment of Oral Diseases

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