Nitric oxide synthase induction and cytotoxic nitrogen-related oxidant formation in conjunctival epithelium of dry eye (Sjögren‘s syndrome)

Čejková, Jitka; Ardan, Taras; Šimonová, Zuzana; Čejka, Čestmír; Malec, J; Jirsová, Kateřina; Filipec, Martin; Dotrelová, D; Brůnová, B

doi:10.1016/j.niox.2007.04.006

Cited by 39 publications

(26 citation statements)

References 28 publications

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“…The tear‐film layer is responsible for the homeostasis of the ocular surface and antioxidant protection against OS. In dry eye syndrome, the expression of various antioxidant enzymes is significantly lower as compared to healthy controls . OS is highly involved in the disruption in the homeostasis, which causes a disorder in the integrity of the ocular surface and damage in extracellular DNA .…”

Section: Noncancer Ocular Pathologiesmentioning

confidence: 99%

Ultraviolet radiation oxidative stress affects eye health

Ivanov

Mappes

Schaupp

et al. 2018

Journal of Biophotonics

142

132

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In the eye, ultraviolet radiation (UVR) is not known to contribute to visual perception but to mainly damage multiple structures. UVR carries higher energy than visible light and high dose exposure to UVR causes direct cellular damage, which has an important role in the development of cancer. This review provides an overview on the most recent knowledge on the role of UVR in oxidative stress (OS) in relation to noncancer ocular pathologies: various corneal pathologies, cataract, glaucoma and age-related macular degeneration. Possible OS signaling streams and mechanisms in the aging eye are discussed. Excessive exposure to UVR through live may seriously contribute to increase in OS of various eye tissues and thus lead to the advancement of serious ocular pathologies. Children are especially vulnerable to UVR because of their larger pupils and more transparent ocular media: up to 80% of a person's lifetime exposure to UVR is reached before the age of 18. Therefore, efficient everyday protection of the sensitive tissues of the eye by wearing of sunglasses, clear UVR-blocking spectacles or contact lenses should be considered from early age on. Many initiatives are taken worldwide to inform and raise the population's awareness about these possible UVR hazards to the eye.

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Section: Noncancer Ocular Pathologiesmentioning

confidence: 99%

Ultraviolet radiation oxidative stress affects eye health

Ivanov

Mappes

Schaupp

et al. 2018

Journal of Biophotonics

142

132

View full text Add to dashboard Cite

show abstract

“…It has also been demonstrated that hyaluronate in anterior chamber during phacoemulsification has a pivotal role in controlling the inflammation, possibly on account of its preventing action in the formation of free radicals. 50 Based on the results of Cejková et al, 51 which point out that reactive nitrogen species are involved in the pathogenesis or selfpropagation of autoimmune dry eye syndrome, it could be hypothesized that hyaluronan might be the most appropriate molecule when the use of a lubricant is mandatory.…”

Section: Discussionmentioning

confidence: 99%

Effect of Hypotonic 0.4% Hyaluronic Acid Drops in Dry Eye Patients: A Cross-Over Study

Troiano

Monaco

2008

Cornea

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“…53 Recently, reactive nitrogen species have just been investigated in dry eye and it has been suggested that they might be involved in the pathogenesis or self-propagation of autoimmune dry eye (SS). 54 In the same study, IL-1β, IL-6, IL-8, TNFα were also investigated and the staining of these cytokines was found to be more in dry eyes in contrast to normal eyes. 54 The response of cells to extracellular stimuli such as ocular surface stress including increased tear fi lm and ultraviolet light exposure is mediated in part by a number of intracellular kinase and phosphatase enzymes.…”

Section: Ocular Surface Infl Ammationmentioning

confidence: 96%

“…54 In the same study, IL-1β, IL-6, IL-8, TNFα were also investigated and the staining of these cytokines was found to be more in dry eyes in contrast to normal eyes. 54 The response of cells to extracellular stimuli such as ocular surface stress including increased tear fi lm and ultraviolet light exposure is mediated in part by a number of intracellular kinase and phosphatase enzymes. 55,56 Stress-activated protein kinases have been identifi ed for this purpose.…”

Section: Ocular Surface Infl Ammationmentioning

confidence: 96%

The role of inflammation and antiinflammation therapies in keratoconjunctivitis sicca

Gümüş

Cavanagh

2008

OPTH

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Purpose: To review and integrate recent advances in identifying the role of infl ammation in the pathogenesis of dry eye conditions and the biological rationale and practical clinical aspects of newer, antiinfl ammatory theories. Methods: A comprehensive literature survey. Results and conclusion: Keratoconjunctivitis Sicca (KCS) is a multifactorial and complex disorder in which ocular surface infl ammations play a central role. Identifi cation of specifi c CD4-T-Cell pathways and the recent recognition of targeting of alpha-fodrin suggest a case for novel new therapeutic aspects such as anti-CD4 monoclonal antibodies, systemic linoleic and gamma-linolenic acids, and omega-6 essential fatty acids. Replacement of tear volume with nonpreserved wetting agents and standard typical antiinfl ammatory corticosteroid and/or cyclosporine A continues to be central current conventional therapy for KCS. Keywords: dry eye, keratoconjunctivitis sicca, antiinfl ammatory therapy Dry eye disease or keratoconjunctivitis sicca (KCS) is a common disorder which refers to a spectrum of ocular surface diseases with multiple etiologies.1 KCS is associated with symptoms of ocular discomfort such as burning, sense of dryness, foreign body sensation, ocular pain, and is sometimes associated with photophobia, blurred vision, visual fatigue, and sight-threatening corneal complications in severe cases. 2,3Epidemiologic studies have stated that more than 6% of the population complains of dry eye symptoms, and this ratio increases to 15% over the age of 65. [4][5][6] Most of the studies have also found an increasing prevalence with aging and greater prevalence among women due to the hormonal status. 4,6,7 Pathogenesis of KCS has not been completely clarified. Even though KCS has been thought of classically and basically as a condition of tear deficiency, whether caused by decreased lacrimation or excessive evaporation, it is a complex disorder. Many clinicopathological entities involving tear film, lacrimal glands, eyelids, and a wide spectrum of ocular surface cells, including epithelial, inflammatory, immune, and goblet cells may play a role in its pathogenesis. 2,8Over the past years, as a result of numerous studies, new concepts of pathogenesis have shown that KCS seems to be caused by infl ammation mediated by T-cell lymphocytes. [9][10][11] This fi nding has also been augmented by the studies investigating the role of antiinfl ammatory therapies. For instance, the treatment of KCS gained a new dimension with the approval of topical 0.05% cyclosporine A (Restasis) (Allergan, Inc., package insert for Restasis) by the US Food and Drug Administration. Consequently, because of the increasing importance of the role of infl ammation and the use of cyclosporine eye drops, the goal of this review article is to provide the readers with an overview of Clinical Ophthalmology downloaded from https://www.dovepress.com/ by 35.167.132.9 on 10-May-2018 For personal use only.Powered by TCPDF (www.tcpdf.org)

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Nitric oxide synthase induction and cytotoxic nitrogen-related oxidant formation in conjunctival epithelium of dry eye (Sjögren‘s syndrome)

Cited by 39 publications

References 28 publications

Ultraviolet radiation oxidative stress affects eye health

Ultraviolet radiation oxidative stress affects eye health

Effect of Hypotonic 0.4% Hyaluronic Acid Drops in Dry Eye Patients: A Cross-Over Study

The role of inflammation and antiinflammation therapies in keratoconjunctivitis sicca

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