Nitric oxide-releasing sol–gels as antibacterial coatings for orthopedic implants

Nablo, Brian J.; Rothrock, Aaron R.; Schoenfisch, Mark H.

doi:10.1016/j.biomaterials.2004.03.031

Cited by 186 publications

(126 citation statements)

References 39 publications

Supporting

Mentioning

122

Contrasting

Order By: Relevance

“…The coatings were capable of inhibiting adhesion of biofilm bacteria, e.g. P. aeruginosa, S. aureus, and S. epidermidis [150,151]. Polymer coatings that allow for modulation of NO release, controlled either by light, (e.g.…”

Section: Surface Modification For Biofilm Prevention and Dispersalmentioning

confidence: 99%

Nitric Oxide: A Key Mediator of Biofilm Dispersal with Applications in Infectious Diseases

Barraud¹,

Kelso²,

Rice

et al. 2014

CPD

216

196

View full text Add to dashboard Cite

Studies of the biofilm life cycle can identify novel targets and strategies for improving biofilm control measures. Of particular interest are dispersal events, where a subpopulation of cells is released from the biofilm community to search out and colonize new surfaces. Recently, the simple gas and ubiquitous biological signaling molecule nitric oxide (NO) was identified as a key mediator of biofilm dispersal conserved across microbial species. Here, we review the role and mechanisms of NO mediating dispersal in bacterial biofilms, and its potential for novel therapeutics. In contrast to previous attempts using high dose NO aimed at killing pathogens, the use of low, non-toxic NO signals (picomolar to nanomolar range) to disperse biofilms represents an innovative and highly favourable approach to improve infectious disease treatments. Further, several NO-based technologies have been developed that offer a versatile range of solutions to control biofilms, including: (i) NO-generating compounds with short or long half-lives and safe or inert residues, (ii) novel compounds for the targeted delivery of NO to infectious biofilms during systemic treatments, and (iii) novel NO-releasing materials and surface coatings for the prevention and dispersal of biofilms. Overall the use of low levels of NO exploiting its signaling properties to induce dispersal represents an unprecedented and promising strategy for the control of biofilms in clinical and industrial contexts. AbstractStudies of the biofilm life cycle can identify novel targets and strategies for improving biofilm control measures. Of particular interest are dispersal events, where a subpopulation of cells is released from the biofilm community to search out and colonize new surfaces. Recently, the simple gas and ubiquitous biological signaling molecule nitric oxide (NO) was identified as a key mediator of biofilm dispersal conserved across microbial species. Here, we review the role and mechanisms of NO mediating dispersal in bacterial biofilms, and its potential for novel therapeutics. In contrast to previous attempts using high dose NO aimed at killing pathogens, the use of low, non-toxic NO signals (picomolar to nanomolar range) to disperse biofilms represents an innovative and highly favourable approach to improve infectious disease treatments. Further, several NO-based technologies have been developed that offer a versatile range of solutions to control biofilms, including: (i) NO-generating compounds with short or long half-lives and safe or inert residues, (ii) novel compounds for the targeted delivery of NO to infectious biofilms during systemic treatments, and (iii) novel NO-releasing materials and surface coatings for the prevention and dispersal of biofilms. Overall the use of low levels of NO exploiting its signaling properties to induce dispersal represents an unprecedented and promising strategy for the control of biofilms in clinical and industrial contexts. 3 Increased antimicrobial tolerance in biofilms is the basis for chronic infecti...

show abstract

Section: Surface Modification For Biofilm Prevention and Dispersalmentioning

confidence: 99%

Nitric Oxide: A Key Mediator of Biofilm Dispersal with Applications in Infectious Diseases

Barraud¹,

Kelso²,

Rice

et al. 2014

CPD

216

196

View full text Add to dashboard Cite

show abstract

“…Some more notable accomplishments utilizing NO include a reversal of hypoxic pulmonary vasoconstriction using inhaled NO, the development of an antimicrobial sol-gel for coating biomaterials used in implants, and an electrochemical oxygen probe which uses NO as an anticlotting agent [42][43][44].…”

Section: Introductionmentioning

confidence: 99%

Nitric Oxide Sensors for Biological Applications

2018

View full text Add to dashboard Cite

Nitric oxide (NO) is an essential signaling molecule within biological systems and is believed to be involved in numerous diseases. As a result of NO's high reaction rate, the detection of the concentration of NO, let alone the presence or absence of the molecule, is extremely difficult. Researchers have developed multiple assays and probes in an attempt to quantify NO within biological solutions, each of which has advantages and disadvantages. This review highlights many of the current NO sensors, from those that are commercially available to the newest sensors being optimized in research labs, to assist in the understanding and utilization of NO sensors in biological fields.

show abstract

“…It is a potent inhibitor of platelet adhesion and aggregation [1,2], inhibits bacterial adhesion and proliferation [3], is implicated in mediating the inflammatory response toward implanted devices [4], inhibits smooth muscle cell growth and proliferation [5,6], and is a neurotransmitter. There has been much interest in developing NO-releasing and NO-generating materials in an effort to harness the power of NO to mediate biological responses toward materials used to fabricate or coat biomedical devices.…”

Section: Introductionmentioning

confidence: 99%

S-Nitroso-N-acetyl-D-penicillamine covalently linked to polydimethylsiloxane (SNAP–PDMS) for use as a controlled photoinitiated nitric oxide release polymer

Gierke

Nielsen

Frost

2011

Science and Technology of Advanced Materials

View full text Add to dashboard Cite

Nitric oxide (NO) plays a critical role in the regulation of a wide variety of physiological processes. It is a potent inhibitor of platelet adhesion and aggregation, inhibits bacterial adhesion and proliferation, is implicated in mediating the inflammatory response toward implanted devices, plays a role in tumor growth and proliferation, and is a neurotransmitter. Herein, we describe the synthesis and NO-release properties of a modified polydimethylsiloxane that contains S-nitroso-N-acetyl-D-penicillamine covalently attached to the cross-linking agent (SNAP-DMS). Light from a C503B-BAN-CY0C0461 light-emitting diode (470 nm) was used as an external trigger to allow precise control over level and duration of NO release ranging from a surface flux of zero to approximately 3.5 × 10 −10 mol cm −2 min −1 . SNAP-PDMS films stored in the dark released NO after 297 days, indicating the long-term stability of SNAP-PDMS.

show abstract

Nitric oxide-releasing sol–gels as antibacterial coatings for orthopedic implants

Cited by 186 publications

References 39 publications

Nitric Oxide: A Key Mediator of Biofilm Dispersal with Applications in Infectious Diseases

Nitric Oxide: A Key Mediator of Biofilm Dispersal with Applications in Infectious Diseases

Nitric Oxide Sensors for Biological Applications

S-Nitroso-N-acetyl-D-penicillamine covalently linked to polydimethylsiloxane (SNAP–PDMS) for use as a controlled photoinitiated nitric oxide release polymer

Contact Info

Product

Resources

About