Nitric Oxide-Releasing Platforms for Treating Cardiovascular Disease

He, Mingyue; Wang, Deping; Xu, Yumei; Jiang, Fangying; Zheng, Jinhai; Yu, Feng; Cao, Ji-Min; Zhou, Xin

doi:10.3390/pharmaceutics14071345

Cited by 13 publications

(8 citation statements)

References 151 publications

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“…Various types of NO donors, like glyceryl trinitrate (GTN), sodium nitroprusside (SNP), diethylamine diazeniumdiolate (DEA/NO), and RSNOs, RIG200 are currently being explored as possible mechanisms to achieve a sustained release of NO in cardiovascular systems. [ 233 ] Flierl et al. demonstrated low adhesion of activated platelets to fibrinogen in the presence of pentaerythritol tetranitrate (PETN; NO donor) by 50% compared to the control (untreated fibrinogen samples).…”

Section: Biomedical Applicationsmentioning

confidence: 99%

“…So, the effect of different NO donors in the presence of these scavengers needs to be properly exploited to better understand the aggregation effect of the activated platelets. [ 233a ] Sogo et al reported not only the platelet inhibitory effect of each NO donor (e.g., GTN, SNP, GSNO, DEA/NO, and RIG200) but also the effect of endogenous NO scavengers on the attachment of activated platelets to a collagen treated surface. Fe(II)Hb and ODQ inhibited the effect of the NO donors.…”

Section: Biomedical Applicationsmentioning

confidence: 99%

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Nitric Oxide: Physiological Functions, Delivery, and Biomedical Applications

Andrabi,

Sharma,

Karan

et al. 2023

Advanced Science

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Nitric oxide (NO) is a gaseous molecule that has a central role in signaling pathways involved in numerous physiological processes (e.g., vasodilation, neurotransmission, inflammation, apoptosis, and tumor growth). Due to its gaseous form, NO has a short half‐life, and its physiology role is concentration dependent, often restricting its function to a target site. Providing NO from an external source is beneficial in promoting cellular functions and treatment of different pathological conditions. Hence, the multifaceted role of NO in physiology and pathology has garnered massive interest in developing strategies to deliver exogenous NO for the treatment of various regenerative and biomedical complexities. NO‐releasing platforms or donors capable of delivering NO in a controlled and sustained manner to target tissues or organs have advanced in the past few decades. This review article discusses in detail the generation of NO via the enzymatic functions of NO synthase as well as from NO donors and the multiple biological and pathological processes that NO modulates. The methods for incorporating of NO donors into diverse biomaterials including physical, chemical, or supramolecular techniques are summarized. Then, these NO‐releasing platforms are highlighted in terms of advancing treatment strategies for various medical problems.

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Section: Biomedical Applicationsmentioning

confidence: 99%

Section: Biomedical Applicationsmentioning

confidence: 99%

Nitric Oxide: Physiological Functions, Delivery, and Biomedical Applications

Andrabi,

Sharma,

Karan

et al. 2023

Advanced Science

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“…Decreased NO synthesis, release, and/or activity in ECs have been associated with the development of CVD. 45 NO, a highly reactive and gas diffusible free radical with potent vasodilatory, anti-inflammatory, and antioxidant properties, plays key roles in regulating vascular tone, angiogenesis, inflammatory cell adhesion, and platelet aggregation. 46 The biosynthesis of NO in ECs is catalyzed by endothelial nitric oxide synthase (eNOS).…”

Section: Decreased No Productionmentioning

confidence: 99%

Hyperuricemia: A key contributor to endothelial dysfunction in cardiovascular diseases

et al. 2023

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As an end product of purine metabolism, uric acid (UA) is a major endogenous antioxidant in humans. However, impaired UA synthesis and excretion can lead to hyperuricemia (HUA), which may in turn induce endothelial dysfunction (ED) and contribute to the pathogenesis of cardiovascular diseases (CVDs; e.g., atherosclerosis and hypertension). In this review, we discuss recent advances and novel insights into the effects exerted by HUA conditions in ED and related underlying mechanisms focusing on impaired UA metabolism, reduction in the synthesis and bioavailability of nitric oxide, endothelial cell injury, the endothelial‐to‐mesenchymal transition, insulin resistance, procoagulant activity, and acquisition of an inflammatory phenotype. We additionally discuss intervention strategies for HUA‐induced ED and the paradoxical roles of UA in endothelial function. We summarize major conclusions and perspectives: the deleterious effects of HUA contribute to the initiation and progression of CVD‐related ED. However, the treatment strategies (in addition to urate‐lowering therapy) for increasing endothelial function are limited because the majority of literature on pharmacological and pathophysiological mechanisms underlying HUA‐induced ED solely describes in vitro models. Therefore, a better understanding of the mechanisms involved in HUA‐induced ED is critical to the development of novel therapies for preventing and treating CVD‐HUA comorbidities.

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“…This leads to vasoconstriction, reduced blood flow, and elevated blood pressure, all of which contribute to the development of cardiovascular diseases 34 . Several drugs target the NO pathway for treating hypertension CVDs, 39 including ACE inhibitors, angiotensin receptor blockers, and organic nitrate drugs. These drugs either increase or enhance NO production, leading to vasodilation, reduced blood pressure, and improved cardiovascular function 40 .…”

Section: Hypertension and Cardiovascular Diseasesmentioning

confidence: 99%

Impact of ultraviolet radiation on cardiovascular and metabolic disorders: The role of nitric oxide and vitamin D

Quan,

Yoon,

Lee

et al. 2023

Photoderm Photoimm Photomed

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Background/PurposeUltraviolet (UV) radiation has both harmful and beneficial effects on human skin and health. It causes skin damage, aging, and cancer; however, it is also a primary source of vitamin D. Additionally, UV radiation can impact energy metabolism and has protective effects on several cardiovascular and metabolic disorders in mice and humans. However, the mechanisms of UV protection against these diseases have not been clearly identified.MethodsThis review summarizes the systemic effects of UV radiation on hypertension and several metabolic diseases such as obesity, diabetes, and nonalcoholic fatty liver disease (NAFLD) in mice, and we also consider the mechanisms of action of the related regulators nitric oxide (NO) and vitamin D.ResultsUV exposure can lower blood pressure and prevent the development of cardiovascular diseases and metabolic disorders, such as metabolic syndrome, obesity, and type 2 diabetes, primarily through mechanisms that depend on UV‐induced NO. UV radiation may also effectively delay the onset of type 1 diabetes through mechanisms that rely on UV‐induced vitamin D. UV‐induced NO and vitamin D play roles in preventing and slowing the progression of NAFLD.ConclusionUV exposure is a promising nonpharmacological intervention for cardiovascular and metabolic disorders. NO and vitamin D may play a crucial role in mediating these effects. However, further investigations are required to elucidate the exact mechanisms and determine the optimal dosage and exposure duration of UV radiation.

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Nitric Oxide-Releasing Platforms for Treating Cardiovascular Disease

Cited by 13 publications

References 151 publications

Nitric Oxide: Physiological Functions, Delivery, and Biomedical Applications

Nitric Oxide: Physiological Functions, Delivery, and Biomedical Applications

Hyperuricemia: A key contributor to endothelial dysfunction in cardiovascular diseases

Impact of ultraviolet radiation on cardiovascular and metabolic disorders: The role of nitric oxide and vitamin D

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