Nitric oxide-releasing/generating polymers for the development of implantable chemical sensors with enhanced biocompatibility

Wu, Yiduo; Meyerhoff, Mark E.

doi:10.1016/j.talanta.2007.06.022

Cited by 58 publications

(62 citation statements)

References 72 publications

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“…In addition, the biocompatibility of implanted chemical sensors can be enhanced significantly by using NO-releasing polymers as a coating material. 13 We have reported the preparation and properties of polymeric and model secondary amines.14 The polymers were prepared from a series of homologous aliphatic diamines and the activated dihalide, 1,5-difluoro-2,4-dinitrobenzene (DFDNB) by nucleophilic aromatic substitution reactions in diphenyl sulfone at elevated temperatures. Reactions of DFDNB with two equivalents of homologous monoamines resulted in the formation of the desired model compounds.…”

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confidence: 99%

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Preparation and Properties of Polyamines: Part II–Controlled and Sustained Release of Nitric Oxide (NO) from Nitrosated Polymers

Wang¹,

Teng

et al. 2009

Polym. J.

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The secondary amine moieties of polyamines prepared by the reactions of aliphatic diamines, and 1,5-difluoro-2,4-dinitrobenzene, were nitrosated using sodium nitrite and aqueous concentrated sulfuric acid at low temperature. Released NO from these polymers, suspended in water or phosphate buffer solutions (PBS), was measured at increasing time intervals by colorimetric techniques using Griess Reagent. Similar tests were also conducted with model compounds. In general, both the model compounds and the corresponding polymers exhibited similar NO release profiles, with apparent half lives up to 88 h and 81 h, respectively. They were strongly dependent on the length of the alkyl chains derived from the primary amines used for the preparation of these NO-releasing materials. Results from in vitro studies using low molecular weight NO-releasing compounds with PC-12 cell are also reported. High concentration of NO induced neuronal cell death. On the other hand, low concentration of NO inhibited cell death induced by oxidative stress. This suggests that cell survival effect is NO-dependent.KEY WORDS: Nitrosated Polyamines / Nitric Oxide / Controlled Release / Cell Culture / Nitrogen monoxide, NO, more commonly known as nitric oxide, plays a critical role in a variety of biological functions.1-3 Towards the end of 1987, the discovery that mammalian cells synthesize nitric oxide, which regulates virtually every critical cellular function, has led to an explosion of research activities.4,5 For example, NO, which is produced from the amino acid L-Arginine in vivo, is involved in the regulation of neurotransmissions, blood pressure, and immune response.6 Nitric oxide can exist as a radical, NO , as a positively charged ion, NO þ (nitrosonium ion), and as nitroxyl anion (NO À ). 7 This allows NO to participate in numerous important biological functions mentioned above as well as others. Diseased states ensue when the bioavailability of NO, for a variety of reasons, becomes impaired. 8,9 Exogenous NO, derived from various families of NO-donors, has been used to ameliorate debilitating symptoms of a few of these diseases. 10A vast majority of NO-donors are low molecular weight compounds including: nitrates, nitrites, N-nitroso, C-nitroso, certain heterocycles, metal-NO complexes, and diazeniumdiolates. 10 Depending on the chemical nature of these compounds, NO is released spontaneously either in the presence or the absence of a catalyst. In the case of diazeniumdiolates, half-life of NO generation can be varied between 2 s to 56 h by changing the nature of the backbone to which the diazenuimdiolate moiety is attached. 11In contrast to the low molecular weight NO-donors, which have been investigated extensively, polymeric NO donors are new arrivals in this field. Since NO is known to prevent platelet aggregation, 12 NO generating polymers can be used as biomaterials, which are likely to come in contact with blood. In addition, the biocompatibility of implanted chemical sensors can be enhanced significantly by using NO-releasing...

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confidence: 99%

Preparation and Properties of Polyamines: Part II–Controlled and Sustained Release of Nitric Oxide (NO) from Nitrosated Polymers

Wang¹,

Teng

et al. 2009

Polym. J.

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“…In addition, the leaching of NO donor into the aqueous phase would reduce the effectiveness of locally released NO to inhibit platelet adhesion/activation at the polymer/blood interface. 187 An alternative concept of " NO generation " is to utilize endogenous RSNO species that exist in physiological fl uids as a continuously replenishing NO donor to generate enhanced NO levels at the blood/polymer interface. RSNOs are regarded as a reservoir and carrier of NO in the body.…”

Section: Prevention Of Infl Ammation On Materials Surfaces By the Relementioning

confidence: 99%

“…The same polymer was also shown to generate NO from nitrite under physiological conditions in the presence of ascorbate. 187 As Cu 2+ is cytotoxic and can leach, the question arises as to its biological effects when attempting to translate such approaches to the in vivo situation.…”

Section: Prevention Of Infl Ammation On Materials Surfaces By the Relementioning

confidence: 99%

Antimicrobial and Anti‐Inflammatory Intelligent Surfaces

Griesser

Hall

Jenkins

et al. 2012

Intelligent Surfaces in Biotechnology

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“…1 Plasma protein deposition on the foreign material may trigger acute immune responses, characterized by the attack of leukocytes. 2 Platelet activation and coagulation can lead to clot formation. A clot that forms on the surface of a blood implantable device may severely affect the normal performance of the device.…”

Section: Introductionmentioning

confidence: 99%

Biocompatibility of surfactant‐templated polyurea–nanoencapsulated macroporous silica aerogels with plasma platelets and endothelial cells

Venkitachalam

Jarrett

Staggs

et al. 2009

J Biomedical Materials Res

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The recently synthesized polyurea-nanoencapsulated surfactant-templated aerogels (X-aerogels) are porous materials with significantly improved mechanical strengths. Surface-wise they resemble polyurethane, a common biocompatible material, but their biocompatibility has never been investigated. As lightweight and strong materials, if X-aerogels also have acceptable biocompatibility, they may be used in many implantable devices. The goal of this study was to investigate their biocompatibility toward platelets, blood plasma, and vascular endothelial cells, in terms of cell activation and inflammatory responses. Platelets were incubated with X-aerogel and platelet activation was measured through CD62P and phosphatidylserine expression. Platelet aggregation was also measured. Contact with X-aerogel did not induce platelet activation or impair aggregation. To determine X-aerogel-induced inflammation, plasma anaphylatoxin C3a level was measured after incubation with X-aerogel. Results showed that X-aerogel induced no changes in plasma C3a levels. SEM and SDS-PAGE were used to examine cellular/protein deposition on X-aerogel samples after plasma incubation. No structural change or organic deposition was detected. Furthermore, X-aerogel samples did not induce any significant changes in vascular endothelial cell culture parameters after 5 days of incubation. These observations suggest that X-aerogels have a suitable biocompatibility toward platelets, plasma, and vascular endothelial cells, and they have potential for use in blood implantable devices.

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Nitric oxide-releasing/generating polymers for the development of implantable chemical sensors with enhanced biocompatibility

Cited by 58 publications

References 72 publications

Preparation and Properties of Polyamines: Part II–Controlled and Sustained Release of Nitric Oxide (NO) from Nitrosated Polymers

Preparation and Properties of Polyamines: Part II–Controlled and Sustained Release of Nitric Oxide (NO) from Nitrosated Polymers

Antimicrobial and Anti‐Inflammatory Intelligent Surfaces

Biocompatibility of surfactant‐templated polyurea–nanoencapsulated macroporous silica aerogels with plasma platelets and endothelial cells

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