Nitric oxide release activated near-Infrared photothermal agent for synergistic tumor treatment

Xu, Yang; Wang, Shiqi; Chen, Zhenjiang; Hu, Rui; Zhao, Yihua; Wang, Kexin; Qu, Junle; Liu, Liwei

doi:10.1016/j.biomaterials.2021.121017

Cited by 53 publications

(20 citation statements)

References 36 publications

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“…The fluorescence self-reporting method as a new method for self-reporting NO release still remains to be validated by many other standard methods, including EPR, electrochemical method, and the Griess assay. ,, The results of ERP spectrum and electrochemical method all demonstrated the successful NO release from 3a by UV light irradiation (Figure f,g). The Griess assay is a widely accepted method for the detection of NO.…”

Section: Resultsmentioning

confidence: 99%

Light-Triggered Fluorescence Self-Reporting Nitric Oxide Release from Coumarin Analogues for Accelerating Wound Healing and Synergistic Antimicrobial Applications

et al. 2021

J. Med. Chem.

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Nitric oxide (NO) has an important class of endogenous diatomic molecules that play a key regulatory role in many physiological and biochemical processes. However, the type of nitrosamine NO donor stimulated by light has many advantages compared to the conventional NO donors such as diazeniumdiolates and S-nitrosothiols compounds, including easy synthesis, good stability, and controllable release. In addition, NO release can be regulated by light induction with a built-in calibration mechanism fluorescence. Here, we report that the migration and proliferation of human umbilical vein vascular endothelial cells could be accelerated by the light-triggered NO donors, leading to the angiogenesis. Meanwhile, the screened NO donor 3a with Levofloxacin (Lev) showed synergistic effects to eradicate Methicillin-resistant Staphylococcus aureus (MRSA) biofilms in vitro and treat bacteria-infected wound in vivo.

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Section: Resultsmentioning

confidence: 99%

Light-Triggered Fluorescence Self-Reporting Nitric Oxide Release from Coumarin Analogues for Accelerating Wound Healing and Synergistic Antimicrobial Applications

et al. 2021

J. Med. Chem.

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“…Gas therapy appears to be an emerging and promising “green” therapeutic option due to its high efficacy, biosafety, and biocompatibility. 156 It utilizes specific gases, such as nitric oxide (NO), 157 carbon monoxide (CO), 158 , 159 hydrogen sulfide (H 2 S), 160 and sulfur dioxide (SO 2 ), 161 to complement other treatments. However, it is a challenge to transport gases to defined areas for poor solubility, diffusivity, and inaccurate release.…”

Section: Combined Therapy Targeting Glucose Metabolismmentioning

confidence: 99%

Glucose Metabolism Intervention-Facilitated Nanomedicine Therapy

Li¹,

Li²,

Ai³

et al. 2022

IJN

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Ordinarily, cancer cells possess features of abnormally increased nutrient intake and metabolic pathways. The disorder of glucose metabolism is the most important among them. Therefore, starvation therapy targeting glucose metabolism specifically, which results in metabolic disorders, restricted synthesis, and inhibition of tumor growth, has been developed for cancer therapy. However, issues such as inadequate targeting effectiveness and drug tolerance impede their clinical transformation. In recent years, nanomaterial-assisted starvation treatment has made significant progress in addressing these challenges, whether as a monotherapy or in combination with other medications. Herein, representative researches on the construction of nanosystems conducting starvation therapy are introduced. Elaborate designs and interactions between different treatment mechanisms are meticulously mentioned. Not only are traditional treatments based on glucose oxidase involved, but also newly sprung small molecule agents targeting glucose metabolism. The obstacles and potential for advancing these anticancer therapies were also highlighted in this review.

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“…Nitric oxide (NO), as a short-lived physiological and pathological messenger, has been reported to regulate vasodilation, cell proliferation, migration and death, and the reversion of drug resistance. − Of late, it has been reported that plasma-generated reactive nitrogen species such as NO radical induced ICD in melanoma and pancreatic tumors. , Additionally, NO has also been reported to inhibit immune escape via various mechanisms such as interfering with PD-L1 activation, downregulating HIF-1α, or relieving hypoxia. − Hence, it is speculated that NO serves as an all-in-one immunomodulatory agent that can induce ICD and simultaneously dampen the ITME of tumors for self-amplifying immune therapy independent of other immunomodulatory strategies. However, the inherent instability and short lifespan of NO dramatically limited its applications. − To this end, many efforts have been devoted to developing NO delivery carriers, but these have many issues such as low NO storage, premature NO release, or insufficient NO leakage. − It is still a big challenge to construct a robust nanosystem that possesses abundant NO storage and precisely unleashes NO on demand.…”

Section: Introductionmentioning

confidence: 99%

Black Phosphorus-Synergic Nitric Oxide Nanogasholder Spatiotemporally Regulates Tumor Microenvironments for Self-Amplifying Immunotherapy

Huang

Zhong

et al. 2022

ACS Appl. Mater. Interfaces

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The lack of tumor immunogenicity coupled with the presence of tumor immunosuppression severely hinders antitumor immunity, especially in the treatment of "immune cold" tumors. Here, we have developed a drug-free and NIR-enabled nitric oxide (NO)-releasing nanogasholder (NO PS @BP) composed of an outer cloak of nitrate-containing polymeric NO donor and an inner core of black phosphorus (BP) as the energy converter to spatiotemporally regulate NO-mediated tumor microenvironment remodeling and achieve multimodal therapy. Following NIR-irradiation, BPinduced photothermia and its intrinsic reducing property accelerate NO release from the outer cloak, by which the instantaneous NO burst concomitant with mild photothermia, on the one hand, induces immunogenic cell death (ICD), thereby provoking antitumor responses such as the maturation of dendritic cells (DCs) and the infiltration of cytotoxic T lymphocytes (CTLs); on the other hand, it reverses tumor immunosuppression via Treg inhibition, M2 macrophage restraint, and PD-L1 downregulation, further strengthening antitumor immunity. Therefore, this drug-free NO PS @BP by means of multimodal therapy (NO gas therapy, immune therapy, photothermal therapy) realizes extremely significant curative effects against primary and distant tumors and even metastasis in B16F10 tumor models, providing a new modality to conquer immune cold tumors by NO-potentiated ICD and immunosuppression reversal.

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Nitric oxide release activated near-Infrared photothermal agent for synergistic tumor treatment

Cited by 53 publications

References 36 publications

Light-Triggered Fluorescence Self-Reporting Nitric Oxide Release from Coumarin Analogues for Accelerating Wound Healing and Synergistic Antimicrobial Applications

Light-Triggered Fluorescence Self-Reporting Nitric Oxide Release from Coumarin Analogues for Accelerating Wound Healing and Synergistic Antimicrobial Applications

Glucose Metabolism Intervention-Facilitated Nanomedicine Therapy

Black Phosphorus-Synergic Nitric Oxide Nanogasholder Spatiotemporally Regulates Tumor Microenvironments for Self-Amplifying Immunotherapy

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