Nitric oxide production is increased in the spermatic veins of adolescents with left idiophatic varicocele

Romeo, Carmelo; Ientile, Riccardo; Santoro, Giuseppe; Impellizzeri, Pietro; Turiaco, Nunzio; Impala, P; Cifalà, S.; Cutroneo, Giuseppina; Trimarchi, Fabio; Gentile, C

doi:10.1053/jpsu.2001.20724

Cited by 52 publications

(40 citation statements)

References 20 publications

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“…Varicocele is related with both increased generation of nitric oxide (NO) and spermatozoal reactive species. NO that is synthesized by the enzyme NOS, with low concentration has its important biological roles in male reproductive function, but excessive production of NO have negative effects on sperm parameters quality (Romeo et al;Ricart-Jané et al;Ramya et al, 2011). Our study has showed a significant increase of NOx in the serum of varicocele groups.…”

Section: Discussionsupporting

confidence: 48%

“…Under pathological conditions, ROS production overwhelms the antioxidants defense and causes oxidative stress (OS) (Romeo et al;Zümrütbas et al, 2013). OS have been implicated in reduced fertility in patients with varicocele.…”

Section: Discussionmentioning

confidence: 99%

“…There are studies showing a negative impact on testicular function already in adolescence (Romeo et al, 2001). The mean incident of varicocele is approximately 15% to 20% in healthy men, and interestingly increases to 40% to 70% in men with primary and secondary infertility, so is the most common identifiable cause of infertility in men (Baazeem et al, 2011;Schauer et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

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The Effects of Curcumin on Sperm Parameters and Nitric Oxide Production in Varicocelized Rats

et al. 2015

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SUMMARY:One of the proposed mechanism by which varicocele induces its damage is excessive release of nitric oxide (NO). Several studies have shown the role of NO in poor sperm quality in infertile patients with varicocele. Scientific studies have demonstrated the beneficial effects of curcumin on the sperm parameters. Curcumin as an atoxic antioxidant can reduce production of NO. The aim of this study was to determine the effect of curcumin on NO levels and investigate if curcumin can improve sperm parameters in varicocelized male rats. Thirty male Wistar rats were randomly divided into 5 groups (V1 and V2 (varicocele), T (treatment), Sh (sham) and C was control). In groups V1, V2, T and Sh, the left renal vein was partially ligated to induce varicocele. In groups V1 and V2, sperm parameters and NO level were evaluated 8 and 16 weeks respectively after varicocele induction. Groups T and Sh received 100 mg/kg curcumin and placebo respectively, daily for 8 weeks after 2 months of induced varicocele. Sperm parameters (count, motility, viability and morphology), epididymis and testis weight and also NO concentration were measured. Sperm parameters (count, motility and viability) in groups V1, V2 and Sh were significantly low in comparison with control and treatment groups. The level of NO was significantly increased in serum of rats in groups V1 and V2, whereas group T rat serum in which curcumin was administered, showed decreased NO levels. The values of the epididymis and testis weight had no significant changes (P≤ 0.05) in all groups. Administration of curcumin as a free radical scavenger, can decrease NO level and improve sperm parameters in varicocelized male rats.

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Section: Discussionsupporting

confidence: 48%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The Effects of Curcumin on Sperm Parameters and Nitric Oxide Production in Varicocelized Rats

et al. 2015

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“…Thus, one clinically important issue regarding varicocele is preoperative recognition of who will respond to surgical treatment. Several studies have shown that ROS production is enhanced in varicocele patients [6,7], and that oxidative stress is present in spermatic vein blood and seminal plasma [8][9][10]. Oxidative stress results from an imbalance between the production and reduction of ROS.…”

Section: Discussionmentioning

confidence: 99%

“…In varicocele patients, ROS production is enhanced [6,7], and oxidative stress is present in spermatic vein blood and seminal plasma [8][9][10]. Varicocele treatment can significantly improve sperm parameters, by decreasing ROS concentration and increasing antioxidant capacity, and these effects lead to improved sperm parameters finally [11].…”

Section: Introductionmentioning

confidence: 99%

Genetic polymorphisms in glutathione S-transferase T1 affect the surgical outcome of varicocelectomies in infertile patients

Ichioka¹,

Nagahama²,

Okubo³

et al. 2009

Asian J Androl

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Glutathione S-transferases (GSTs), superoxide dismutase 2 (SOD2) and NAD(P)H:quinone oxidoreductase 1 (NQO1) are anti-oxidant enzyme genes. Polymorphisms of GSTs, SOD2 and NQO1 have been reported to influence individual susceptibility to various diseases. In an earlier study, we obtained preliminary findings that a subset of glutathione S-transferase T1 (GSTT1)-wt patients with varicocele may exhibit good response to varicocelectomy. In this study, we extended the earlier study to determine the distribution of genotype of each gene in the infertile population and to evaluate whether polymorphism of these genes affects the results of surgical treatment of varicocele. We analyzed 72 infertile varicocele patients, 202 infertile patients without varicocele and 101 male controls. Genotypes of GSTs were determined by polymerase chain reaction (PCR). Genotyping of SOD2 and NQO1 was performed using the PCR-restriction fragment length polymorphism (PCR-RFLP) method. A significantly better response to varicocelectomy was found in patients with the GSTT1-wt genotype (63.2%) and NQO1-Ser/Ser genotype (80.0%) than in those with GSTT1-null genotype (35.3%) and NQO1-Pro/Pro or NQO1-Pro/Ser genotype (45.2%), respectively. The frequencies of glutathione S-transferase M1/T1, SOD2 and NQO1 genotypes did not differ significantly among the varicocele patients, idiopathic infertile patients and male controls. GSTT1 genotype is associated with improvement of semen parameters after varicocelectomy. As the number of patients with NQO1-Ser/Ser genotype was not sufficient to reach definite conclusions, the association of NQO1 genotype with varicocelectomy requires further investigation.

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Sperm Chromatin Dispersion Test: Technical Aspects and Clinical Applications

2011

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Nitric oxide production is increased in the spermatic veins of adolescents with left idiophatic varicocele

Cited by 52 publications

References 20 publications

The Effects of Curcumin on Sperm Parameters and Nitric Oxide Production in Varicocelized Rats

The Effects of Curcumin on Sperm Parameters and Nitric Oxide Production in Varicocelized Rats

Genetic polymorphisms in glutathione S-transferase T1 affect the surgical outcome of varicocelectomies in infertile patients

Sperm Chromatin Dispersion Test: Technical Aspects and Clinical Applications

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