Nitric oxide pathway activity modulation alters the protective effects of (−)Epigallocatechin-3-gallate on reserpine-induced impairment in rats

Chen, Cheng-Neng; Chang, Kuan‐Chang; Lin, Rui-Feng; Wang, Mao‐Hsien; Shih, Ruoh-Lan; Tseng, Hsiang-Chien; Soung, Hung-Sheng; Tsai, Cheng-Chia

doi:10.1016/j.bbr.2016.02.038

Cited by 13 publications

(7 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In a systematic review with meta-analysis, Üçeyler et al [ 30 ] found that IL-6 is elevated in FM cases. This is supported by previous findings which linked FM-related changes to inflammation and oxidative stress [ 31 , 32 ]. Reserpine also caused a reduction in locomotor activity that had been related not only to long-lasting muscular mechanical hyperalgesia, tactile allodynia and tenderness [ 33 ] but also to depressive symptoms associating FM [ 16 ].…”

Section: Discussionsupporting

confidence: 91%

Pioglitazone improves skeletal muscle functions in reserpine-induced fibromyalgia rat model

et al. 2021

View full text Add to dashboard Cite

Background: Fibromyalgia (FM) is characterized by musculoskeletal pain, fatigue, sleep and memory disturbance. There is no definitive cure yet for FM-related health problems. Peroxisome proliferator-activated receptor's (PPAR's) activation is associated with insulin sensitisation and improved glucose metabolism. PPAR-c was reported to alleviate FM allodynia. Limited data are discussing its effect on motor disorders. Objective: To investigate the potential effect of PPAR-c agonists (pioglitazone, as one member of thiazolidinediones (TZD)) on motor dysfunction in reserpine-induced FM in a rat model. Materials and methods: Thirty-six male Wistar rats were divided into negative control (n ¼ 9) and reserpine-induced FM (n ¼ 27) groups. The latter was subdivided into three equal subgroups (n ¼ 9), positive control (untreated FM model), pioglitazone-treated and GW9662-treated. We evaluated muscle functions and activity of chloramphenicol acetyltransferase, superoxide dismutase, malondialdehyde, and serum levels of interleukin-8 and monocyte chemoattractant protein-1. Results: Pioglitazone significantly relieved fatigue, improved muscle performance, reduced inflammatory cytokines and enhanced antioxidant's activity, while GW9662, a known PPAR-c antagonist, aggravated the FM manifestations in the rat model. Conclusion: PPAR-c agonists show a promising role against FM-associated motor dysfunctions.

show abstract

Section: Discussionsupporting

confidence: 91%

Pioglitazone improves skeletal muscle functions in reserpine-induced fibromyalgia rat model

et al. 2021

View full text Add to dashboard Cite

show abstract

“…This does not coincide with other studies that reported increased NO levels in reserpine-treated rats (Bilska et al 2007;Chen et al 2016) which lead to the formation of reactive nitrogen species, and nitrosative stress in PD (Olanow 2007). However, the reduced levels of NO, in the current study, may result from the reaction of NO with superoxide (Rockenstein et al 2003).…”

Section: Discussioncontrasting

confidence: 98%

Evaluation of the therapeutic potential of cerebrolysin and/or lithium in the male Wistar rat model of Parkinson’s disease induced by reserpine

et al. 2023

View full text Add to dashboard Cite

Parkinson’s disease (PD) is the second most prevalent neurodegenerative disease worldwide and represents a challenge for clinicians. The present study aims to investigate the effects of cerebrolysin and/or lithium on the behavioral, neurochemical and histopathological alterations induced by reserpine as a model of PD. The rats were divided into control and reserpine-induced PD model groups. The model animals were further divided into four subgroups: rat PD model, rat PD model treated with cerebrolysin, rat PD model treated with lithium and rat PD model treated with a combination of cerebrolysin and lithium. Treatment with cerebrolysin and/or lithium ameliorated most of the alterations in oxidative stress parameters, acetylcholinesterase and monoamines in the striatum and midbrain of reserpine-induced PD model. It also ameliorated the changes in nuclear factor-kappa and improved the histopathological picture induced by reserpine. It could be suggested that cerebrolysin and/or lithium showed promising therapeutic potential against the variations induced in the reserpine model of PD. However, the ameliorating effects of lithium on the neurochemical, histopathological and behavioral alterations induced by reserpine were more prominent than those of cerebrolysin alone or combined with lithium. It can be concluded that the antioxidant and anti-inflammatory effects of both drugs played a significant role in their therapeutic potency.

show abstract

“…In addition, the atrophy of muscle fiber described by Bonaterra et al [ 32 ] is consistent with our results. According other authors [ 19 , 36 ], the underlying mechanisms of these alterations could be inflammation and oxidative stress processes characteristic of FM and also in the RIM model. In particular, our data provide information on the possible mechanisms showing an increase in morphological damage caused by ROS and a reduction in endogenous antioxidants, including SOD and CAT, in gastrocnemius.…”

Section: Discussionmentioning

confidence: 96%

Oral Supplementation of Melatonin Protects against Fibromyalgia-Related Skeletal Muscle Alterations in Reserpine-Induced Myalgia Rats

Favero

Trapletti

Bonomini

et al. 2017

IJMS

View full text Add to dashboard Cite

Fibromyalgia is a chronic syndrome characterized by widespread musculoskeletal pain and an extensive array of other symptoms including disordered sleep, fatigue, depression and anxiety. Important factors involved in the pathogenic process of fibromyalgia are inflammation and oxidative stress, suggesting that ant-inflammatory and/or antioxidant supplementation might be effective in the management and modulation of this syndrome. Recent evidence suggests that melatonin may be suitable for this purpose due to its well known ant-inflammatory, antioxidant and analgesic effects. Thus, in the current study, the effects of the oral supplementation of melatonin against fibromyalgia-related skeletal muscle alterations were evaluated. In detail, 90 Sprague Dawley rats were randomly treated with reserpine, to reproduce the pathogenic process of fibromyalgia and thereafter they received melatonin. The animals treated with reserpine showed moderate alterations at hind limb skeletal muscles level and had difficulty in moving, together with significant morphological and ultrastructural alterations and expression of inflammatory and oxidative stress markers in the gastrocnemius muscle. Interestingly, melatonin, dose and/or time dependently, reduced the difficulties in spontaneous motor activity and the musculoskeletal morphostructural, inflammatory, and oxidative stress alterations. This study suggests that melatonin in vivo may be an effective tool in the management of fibromyalgia-related musculoskeletal morphofunctional damage.

show abstract

Nitric oxide pathway activity modulation alters the protective effects of (−)Epigallocatechin-3-gallate on reserpine-induced impairment in rats

Cited by 13 publications

References 39 publications

Pioglitazone improves skeletal muscle functions in reserpine-induced fibromyalgia rat model

Pioglitazone improves skeletal muscle functions in reserpine-induced fibromyalgia rat model

Evaluation of the therapeutic potential of cerebrolysin and/or lithium in the male Wistar rat model of Parkinson’s disease induced by reserpine

Oral Supplementation of Melatonin Protects against Fibromyalgia-Related Skeletal Muscle Alterations in Reserpine-Induced Myalgia Rats

Contact Info

Product

Resources

About