Nitric oxide metabolism is impaired by type 1 diabetes and diabetic nephropathy

Sokolovska, Jeļizaveta; Dekante, Alise; Баумане, Л.; Pahirko, Leonora; Valeinis, Jānis; Dišlere, Kristīne; Rovīte, Vita; Pīrāgs, Valdis; Sjakste, Nikolajs

doi:10.3892/br.2020.1288

Cited by 18 publications

(19 citation statements)

References 40 publications

(49 reference statements)

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“…The study protocols were approved by the ethics committees in both countries (Latvia: The Latvian Central Ethics Committee; Lithuania: Kaunas Regional Biomedical Research Ethics Committee). In Latvia, the recruitment of the study participants, biobanking, and sample storage were performed in agreement with the procedures of the Genome Database of the Latvian population [ 29 ] and are described in more detail in [ 30 ]. In Lithuania, patients were recruited from the national T1D registry database and from regular medical visits at the Lithuanian University of Health Sciences Hospital.…”

Section: Methodsmentioning

confidence: 99%

Telomere Lengths and Serum Proteasome Concentrations in Patients with Type 1 Diabetes and Different Severities of Diabetic Retinopathy in Latvia and Lithuania

Svikle

Pahirko

Zariņa

et al. 2022

JCM

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The aim of the study was to compare telomere lengths and circulating proteasome concentrations in patients with different stages of diabetic retinopathy and type 1 diabetes in Latvia and Lithuania. Methods. Patients with no diabetic retinopathy and with non-proliferative diabetic retinopathy were included in the NDR/NPDR group (n = 187). Patients with proliferative diabetic retinopathy and status post laser-photocoagulation were included int the PDR/LPC group (n = 119). Telomeres were evaluated by real-time quantitative polymerase chain reaction. Proteasome concentration was measured by ELISA. Results. Telomeres were longer in PDR/LPC (ΔCT 0.21 (0.12–0.28)) vs. NDR/NPDR (ΔCT 0.18 (0.1–0.28)), p = 0.036. In NDR/NPDR, telomeres were correlated negatively with age (R = −0.17, p = 0.019), BMI (R = −0.21, p = 0.004), waist/hip ratio (R = −0.21, p = 0.005), total cholesterol (R = −0.18, p = 0.021), and low-density cholesterol (R = −0.20, p = 0.010), and positively with estimated glomerular filtration rate (eGFR) (R = 0.28, p < 0.001). None of the above correlations were observed in PRD/LPC. Proteasome concentrations were lower in PDR/LPC (130 (90–210) ng/mL) vs. NDR/NPDR (150 (100–240) ng/mL), p = 0.024. This correlated negatively with eGFR (R = −0.17, p = 0.025) in the NDR/NPDR group and positively with age (R = 0.23, p = 0.014) and systolic blood pressure (R = 0.20, p = 0.032) in the PRD/LPC group. Telomere lengths did not correlate with proteasome concentrations. Conclusion. Longer telomeres and lower circulating proteasome concentrations are observed in patients with type 1 diabetes and advanced diabetic retinopathy.

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Section: Methodsmentioning

confidence: 99%

Telomere Lengths and Serum Proteasome Concentrations in Patients with Type 1 Diabetes and Different Severities of Diabetic Retinopathy in Latvia and Lithuania

Svikle

Pahirko

Zariņa

et al. 2022

JCM

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“…The decreased bioavailability of NO, e.g. due to endothelial dysfunction and/or oxidative stress, is implicated in the development of vascular complications of diabetes mellitus [7,8]. Intermediate concentration of NO promotes growth and proliferation of normal cells and angiogenesis [9].…”

Section: Mainmentioning

confidence: 99%

Photocontrolled Release of Nitric Oxide for Precise Management of NO Concentration in a Solution

Zhermolenko

Karogodina

Vorob’ev

et al. 2022

Preprint

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Nitric oxide (NO) is a unique biochemical mediator involved in the regulation of vital processes. Its short half-life and local action impede direct application in medical practice. Light-controllable NO releasers are promising for the development of smart therapies. Here we present novel aza-BODIPY derivative containing N-nitroso moiety, which shows efficient and reversible release of NO under red light. Using this molecule, we demonstrate a system for precise management of NO concentration in aqueous solution in vitro using the feedback loop with optical control. Our results could serve as the basis for the development of novel therapeutic methods.

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“…Nitric oxide (NO) is a key cellular signaling molecule responsible for many physiological processes of human beings. , It is catalytically produced from the reduction of l -arginine by NO synthase (NOS) or enzymatic and nonenzymatic nitrate–nitrite NO conversion processes. − The concentration of NO for a healthy human range from 1 μM to 10 nM and any deviation from this level creates several medical complications . This important molecule plays major roles in various physiological processes, such as neurotransmission, vasodilation, blood pressure regulation, wound healing, and immune response. − As the concentration of NO in our body decreases from the normal value, it causes hypertension, diabetes, Parkinson’s disease, ischemia, fibrosis, etc. − On the other hand, the excessive production of NO causes septic shock, hypertension, excessive bleeding, and rheumatoid arthritis. − Therefore, precisely monitoring NO in our human body can be identified as a potential biomarker for detecting various diseases. However, detection and continuous monitoring of NO in human blood is still a challenge due to its lower concentration (nanomolar), short half-life (less than 10 s), and high reactivity …”

Section: Introductionmentioning

confidence: 99%

Noninvasive Electrochemical Nitric Oxide Detection in Human Saliva Using Pt and TiO₂ Nanoparticle Composite Electrodes

Patra

Deka

Dash

et al. 2023

ACS Appl. Electron. Mater.

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Nitric oxide (NO) plays major roles in various physiological processes, such as neurotransmission, vasodilation, blood pressure monitoring, and immune response. Precise regulation of NO concentration in our body can be measured as a potential biomarker for numerous diseases such as hypertension, diabetes, Parkinson’s disease, ischemia, and rheumatoid arthritis. In this report, an electrochemical NO sensor was fabricated using a nanocomposite material consisting of Pt and TiO2 nanoparticles (Pt-TiO2 NPs). Pt and TiO2 nanoparticles were synthesized using the sol–gel method. NO sensing measurements were carried out using a Pt-TiO2 NPs-modified glassy carbon (GC) electrode after adding various concentrations of NO. The nanoparticles-modified GC electrode demonstrated high sensitivity (∼7.81 μA mM–1cm–2) in a wide linear detection range (∼10 nM to 17.79 mM). The sensor exhibited a very low detection limit (∼2.47 nM), high stability, and excellent selectivity toward NO. NO detection using a Pt-TiO2 NPs-deposited screen-printed carbon electrode was also studied in detail. Such a highly sensitive and selective sensor has been employed for noninvasive NO detection in human saliva.

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Nitric oxide metabolism is impaired by type 1 diabetes and diabetic nephropathy

Abstract: +NO 3 in serum and urine in patients with type 1 diabetes, as identified by linear regression models. The present study concludes that NO metabolism is impaired by type 1 diabetes and diabetic nephropathy.

Cited by 18 publications

References 40 publications

Telomere Lengths and Serum Proteasome Concentrations in Patients with Type 1 Diabetes and Different Severities of Diabetic Retinopathy in Latvia and Lithuania

Telomere Lengths and Serum Proteasome Concentrations in Patients with Type 1 Diabetes and Different Severities of Diabetic Retinopathy in Latvia and Lithuania

Photocontrolled Release of Nitric Oxide for Precise Management of NO Concentration in a Solution

Noninvasive Electrochemical Nitric Oxide Detection in Human Saliva Using Pt and TiO₂ Nanoparticle Composite Electrodes

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Nitric oxide metabolism is impaired by type 1 diabetes and diabetic nephropathy

Abstract: +NO 3 in serum and urine in patients with type 1 diabetes, as identified by linear regression models. The present study concludes that NO metabolism is impaired by type 1 diabetes and diabetic nephropathy.

Cited by 18 publications

References 40 publications

Telomere Lengths and Serum Proteasome Concentrations in Patients with Type 1 Diabetes and Different Severities of Diabetic Retinopathy in Latvia and Lithuania

Telomere Lengths and Serum Proteasome Concentrations in Patients with Type 1 Diabetes and Different Severities of Diabetic Retinopathy in Latvia and Lithuania

Photocontrolled Release of Nitric Oxide for Precise Management of NO Concentration in a Solution

Noninvasive Electrochemical Nitric Oxide Detection in Human Saliva Using Pt and TiO2 Nanoparticle Composite Electrodes

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Noninvasive Electrochemical Nitric Oxide Detection in Human Saliva Using Pt and TiO₂ Nanoparticle Composite Electrodes