Telomere Lengths and Serum Proteasome Concentrations in Patients with Type 1 Diabetes and Different Severities of Diabetic Retinopathy in Latvia and Lithuania

Svikle, Zane; Pahirko, Leonora; Zariņa, Līga; Baumane, Kristīne; Kardonaitė, Deimantė; Radzevičienė, Lina; Daugintytė-Petrušienė, Laura; Balčiūnienė, Vilma Jūratė; Verkauskienė, Rasa; Tiščuka, Angeļina; Rovīte, Vita; Sjakste, Nikolajs; Sokolovska, Jeļizaveta

doi:10.3390/jcm11102768

Cited by 3 publications

(2 citation statements)

References 48 publications

(61 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thus, the role of LTL in IMIDs requires further study. However, the MR study found different results from previous studies: shorter or longer LTL may increase the risk of T1D ( Sanchez et al, 2020 ; Svikle et al, 2022 ), AD ( Wu et al, 2000 ), and PSC ( Laish et al, 2015 ). For instance, two cross-sectional studies found that the TL was shorter in T1D patients than in non-diabetic subjects ( Sanchez et al, 2020 ; Syreeni et al, 2022 ).…”

Section: Discussioncontrasting

confidence: 60%

Immune-mediated inflammatory diseases and leukocyte telomere length: A Mendelian randomization study

et al. 2023

View full text Add to dashboard Cite

Objective: To elucidate the potential causality of leukocyte telomere length (LTL) with immune-mediated inflammatory diseases (IMIDs), we conducted a Mendelian randomization (MR) study.Methods: The genetically predicted causation between LTL and IMIDs was evaluated using a two-sample MR method. We analyzed 16 major IMIDs, which included systemic lupus erythematosus (SLE), inflammatory bowel disease (IBD), ulcerative colitis (UC), Crohn’s disease (CD), ankylosing spondylitis (AS), sicca syndrome (SS), rheumatoid arthritis (RA), type 1 diabetes (T1D), primary sclerosing cholangitis (PSC), idiopathic pulmonary fibrosis (IPF), atopic dermatitis (AD), sarcoidosis, hypothyroidism, hyperthyroidism, psoriasis, and childhood asthma. The random-effects inverse-variance weighted (IVW) method was performed as the main analytical approach in MR. Various sensitivity analyses, including MR-Egger, MR robust adjusted profile score (MR-RAPS), weighted median, MR pleiotropy residual sum and outlier (MR-PRESSO) methods, weighted mode, radial plot, and radial regression, were used to guarantee the robustness of the results and detect horizontal pleiotropy. Cochran’s Q value was calculated to check for heterogeneity, and the MR Steiger approach was used to test the causal direction.Results: The MR results indicated significant inverse associations of LTL with risks of psoriasis (OR: 0.77, 95% CI: 0.66–0.89, and p = 3.66 × 10−4), SS (OR: 0.75, CI: 0.58–0.98, and p = 0.03), RA (OR: 0.77, 95% CI: 0.68–0.88, and p = 9.85 × 10−5), hypothyroidism (OR: 0.84, 95% CI: 0.78–0.91, and p = 7,08 × 10−6), hyperthyroidism (OR: 0.60, 95% CI: 0.44–0.83, and p = 1.90 × 10−3), sarcoidosis (OR: 0.67, 95% CI: 0.54–0.83, and p = 2.60 × 10−4), and IPF (OR: 0.41, 95% CI: 0.29–0.58, and p = 4.11 × 10−7) in the FinnGen study. We observed that longer LTL was associated with an increased risk of AS susceptibility (OR: 1.51, 95% CI: 1.18–1.94, and p = 9.66 × 10−4). The results of the IVW method showed no causal relationship between TL and SLE (OR: 0.92, 95% CI: 0.62–1.38, and p = 0.69) in the FinnGen study; however, a significantly positive correlation was shown between LTL and SLE in another larger GWAS (OR: 1.87, 95% CI: 1.37–2.54, and p = 8.01 × 10−5).Conclusion: Our findings reveal that abnormal LTL has the potential to increase the risk of IMIDs. Therefore, it could be treated as a predictor and may provide new potential treatment targets for IMIDs. However, the change of LTL may not be the direct cause of IMIDs. Further studies should aim at the pathogenic mechanism or potential protective effects of LTL in IMIDs.

show abstract

Section: Discussioncontrasting

confidence: 60%

Immune-mediated inflammatory diseases and leukocyte telomere length: A Mendelian randomization study

et al. 2023

View full text Add to dashboard Cite

show abstract

“…The Reactions were run in light cycler 480 II (Roch). For quality control, A no-template control and duplicate calibrator samples were used in all runs to allow for a comparison of the results across all runs (Svikle et al, 2022). RTL was reflected by T/S values (telomere/36B4 ratio): T/S = 2 −∆ Ct (∆Ct = Ct telomere − Ct36B4).…”

Section: Telomere Length Measurementmentioning

confidence: 99%

Association of Relative Telomere Length and LINE-1 Methylation with Autism but not with Severity

Salem

Ashaat

2023

J Autism Dev Disord

View full text Add to dashboard Cite

Autism is associated with genomic instability, which is regulated by telomere length (TL) and index of global methylation (LINE-1). This study will determine relative TL (RTL) and LINE-1 methylation percentage for 69 patients and 33 control subjects to evaluate their potential role as biomarkers for autism. The results displayed a significant decrease of both RTL and LINE-1 methylation in autistic cases relative to controls (P < 0.001). Analysis of receiver operating characteristics curve revealed that both of RTL and LINE-1 methylation percentage have the ability to serve as autism biomarkers (area under the curve = 0.817 and 0.889, respectively). The statistical analysis revealed positive correlation between the two biomarkers (correlation coefficient = 0.439 and P < 0.001).

show abstract

Progression of Diabetic Kidney Disease and Gastrointestinal Symptoms in Patients with Type I Diabetes

Fedulovs,

Tzivian,

Zalizko

et al. 2023

Biomedicines

View full text Add to dashboard Cite

(1) Background: Little research is conducted on the link between diabetic kidney disease (DKD) progression and diabetic gastroenteropathy in type 1 diabetes (T1D). (2) Methods. We performed a cross-sectional study with 100 T1D patients; 27 of them had progressive DKD, defined as an estimated glomerular filtration rate (eGFR) decline ≥3 mL/min/year or increased albuminuria stage, over a mean follow-up time of 5.89 ± 1.73 years. A newly developed score with 17 questions on gastrointestinal (GI) symptoms was used. Faecal calprotectin was measured by ELISA. Lower GI endoscopies were performed in 21 patients. (3) Results: The gastrointestinal symptom score demonstrated high reliability (Cronbach’s α = 0.78). Patients with progressive DKD had higher GI symptom scores compared to those with stable DKD (p = 0.019). The former group demonstrated more frequent bowel movement disorders (p < 0.01). The scores correlated negatively with eGFR (r = −0.335; p = 0.001), positively with albuminuria (r = 0.245; p = 0.015), Hba1c (r = 0.305; p = 0.002), and diabetes duration (r = 0.251; p = 0.012). Faecal calprotectin levels did not differ between DKD groups significantly. The most commonly reported histopathological findings of enteric mucosa were infiltration with eosinophils, lymphocytes, plasmacytes, the presence of lymphoid follicles, and lymphoid aggregates. Conclusion: The progression of DKD is positively correlated with gastrointestinal symptoms; however, more research is needed to clarify the causal relationships of the gut-kidney axis in T1D.

show abstract

Telomere Lengths and Serum Proteasome Concentrations in Patients with Type 1 Diabetes and Different Severities of Diabetic Retinopathy in Latvia and Lithuania

Cited by 3 publications

References 48 publications

Immune-mediated inflammatory diseases and leukocyte telomere length: A Mendelian randomization study

Immune-mediated inflammatory diseases and leukocyte telomere length: A Mendelian randomization study

Association of Relative Telomere Length and LINE-1 Methylation with Autism but not with Severity

Progression of Diabetic Kidney Disease and Gastrointestinal Symptoms in Patients with Type I Diabetes

Contact Info

Product

Resources

About