Nitric Oxide Levels in Patients with Chronic Renal Disease

Meenakshi, .; Agarwal, Renu

doi:10.7860/jcdr/2013/5972.3119

Cited by 18 publications

(18 citation statements)

References 8 publications

(8 reference statements)

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“…High creatinine levels indicate renal dysfunction or limited perfusion. A study of patients with chronic renal diseases also found a significant positive correlation between serum NO and creatinine levels (r = 0.81) [52]. Furthermore, in our study, CRP showed a positive correlation with NOx levels (+0.23).…”

Section: Glutathione Peroxidase Activity Is Influenced By Smokingsupporting

confidence: 82%

Redox status of patients before cardiac surgery

Schuh

Sheybani²,

Jortzik

et al. 2017

Redox Report

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A: absorption; ΔA: absorption difference; ABTS: 2,2'-azino-di(3-ethylbenzothiazoline sulfonate); ACE: angiotensin-converting enzyme; AO: antioxidant; ARB: angiotensin receptor blocker; BMI: body mass index; CAD: coronary artery disease; CCB: calcium channel blocker; CDC: coronary heart diseases; COPD: chronic obstructive pulmonary disease; CRP: C-reactive protein; CVD: cardiovascular diseases; Cu-OOH: cumene hydroperoxide; D: dilution factor; DAN: 2,3-diaminonaphtalene; DMSO: dimethylsulfoxide; DNA: deoxyribonucleic acid; DTNB: 5,5-dithiobis(2-nitrobenzoate); ε: extinction coefficient; EDRF: endothelium-derived relaxing factor; fc: final concentration; GPx: glutathione peroxidases; (h)GR: (human) glutathione reductase; GSH: (reduced) glutathione; GSSG: glutathione disulfide; GST: glutathione-S-transferase; Hb: hemoglobin; HDL: high-density lipoprotein; Hk: hematocrit; HO: hydrogen peroxide; ICS: intensive care stay; LDH: lactate dehydrogenase; LDL: low-density lipoprotein; MI: myocardial infarction; NED: N-(1-naphthyl)-ethylendiamine-dihydrochloride; NOS: nitric oxide synthase; NOx: nitrate/nitrite; NR: nitrate reductase; PBS: phosphate buffered saline; PCA: principle component analysis; PH: pulmonary hypertension; ROS: reactive oxygen species; RNS: reactive nitrogen species; RT: room temperature (25°C); SA: sulfanilamide; SOD: superoxide dismutase; SSA: sulfosalicylic acid; TAC: total antioxidant capacity; TAOS: total antioxidant status; TEAC: trolox equivalent antioxidative capacity; TG: triglycerides; tGSH: total glutathione; TNB-: 2-nitro-5-thiobenzoate; U: unit; UV: ultraviolet; VA: volume activity; Wc: working concentration; WHR: waist-hip ratio.

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Section: Glutathione Peroxidase Activity Is Influenced By Smokingsupporting

confidence: 82%

Redox status of patients before cardiac surgery

Schuh

Sheybani²,

Jortzik

et al. 2017

Redox Report

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“…The IC 50 value of HEX-F was significantly lower compared to that of quercetin (P < 0.05) suggesting that HEX-F has higher NO scavenging abilities. Therefore, the ability of T. conophorum seed extracts to scavenge NO • against tissue damage is implicated in this study (32,33).…”

Section: Discussionmentioning

confidence: 99%

Phytochemical Investigation and In Vitro Antioxidant Activities of Tetracarpidium conophorum (African Walnut) Seeds

Oriakhi

Orumwensodia

Uadia

2018

Avicenna J Med Biochem

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Background: Tetracarpidium conophorum (African walnut) is an African plant with ethnobotanical uses. Objectives: The purpose of this study was to evaluate the phytochemical screening and in vitro antioxidant activities of methanol extract and fractions (F) [n-hexane (HEX-F), dichloromethane (DCM-F) and, ethyl acetate (EA-F)] of T. conophorum seeds. Methods: Phytochemical screening and in vitro antioxidant activity study were carried out using DPPH, ABTs radical scavenging assays, nitric oxide inhibitory and reducing potential assays. Results: Methanol extract and its fractions contain phenols, flavonoids, saponins, tannins, terpenoids, and alkaloids. The concentrations of total phenols and flavonoids content were significantly higher in EA-F and crude methanol extract compared to other fractions. Crude methanol and EA-F contain higher concentrations of tannin while hexane fraction had the lowest tannin content but relatively higher proanthocyanidin content compared to other fractions. The antioxidant activity study showed that both methanol crude extract and fractions of T. conophorum seeds have significant activities for DPPH radical scavenging, reducing power, ferric reducing antioxidant potential, nitric oxide inhibitory activities, ABTS and hydroxyl radical scavenging for. DPPH radical scavenging activities of EA-F showed the lowest IC50 of 33.11 µg/mL, followed by Hex-F, DCM-F and crude methanol extract with IC50 of 33.43, 42.09 and 45.44 µg/mL, respectively, when compared to ascorbic acid with IC50 of 17.08 µg/mL. Conclusion: The study showed that T. conophorum seed is a rich source of secondary metabolites, which may be responsible for its antioxidant activities.

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“…Some other authors and literature data regarding physiology and pathophysiology of NO in ESRD patients treated with one of dialysis modes are contradictory. 6 One group of data suggests that serum levels of NO in ESRD Figure 1. Mean serum levels of NO in all studied subjects (1-healthy subjects; 2-CAPD patients).…”

Section: Discussionmentioning

confidence: 99%

“…All these disorders in blood vessels can cause endothelial dysfunction. [5][6][7] It is well known that cardiovascular diseases (e.g., hypertension) are leading cause of death in ESRD patients. Endothelial damaging as well as imbalance in production of vasoactive substances can be connected with these facts.…”

Section: Introductionmentioning

confidence: 99%

Serum levels of nitric oxide and endothelin-1 in patients treated with continuous ambulatory peritoneal dialysis

et al. 2013

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End-stage renal disease (ESRD) and its treatment modules affect almost all organs and organ systems including vascular endothelium. It is well known that disturbance of vasoactive substances (nitric oxide -NO and endothelin-1 -ET-1) production appears in these patients. There is a small number of studies which investigated serum levels of NO and ET-1 in ESRD patients treated with continuous ambulatory peritoneal dialysis (CAPD). Therefore our study aimed to measure serum levels of NO and ET-1 in this population. This study included 23 ESRD patients (10 males and 13 females) treated with CAPD, mean age 55.8 AE 15.8 years. Mean duration of CAPD treatment in this group of patients was 3.4 AE 14.7 years. Besides this group of patients (CAPD), we included a second group which consisted of 30 healthy controls [14 males, 16 females, mean age 51.8 (AE15.6) years]. Our results show significantly higher serum levels of NO in CAPD patients ( x AE SD ¼ 19.09 AE 6.9) in comparison to the control group ( x AE SD ¼ 9.5 AE 1.9) (p50.05). There was no significant difference in serum levels of ET-1 between CAPD patients ( x AE SD ¼ 7.3 AE 5.6) and the control group ( x AE SD ¼ 6.6 AE 4.2), (p40.05). From our results, we concluded that imbalance in production of vasoactive substances is present in CAPD patients. This imbalance can lead to disturbance in local blood flow control. These pathophysiological mechanisms can cause significant hemodynamic disturbance (hypertension) and atherosclerosis.

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Nitric Oxide Levels in Patients with Chronic Renal Disease

Cited by 18 publications

References 8 publications

Redox status of patients before cardiac surgery

Redox status of patients before cardiac surgery

Phytochemical Investigation and In Vitro Antioxidant Activities of Tetracarpidium conophorum (African Walnut) Seeds

Serum levels of nitric oxide and endothelin-1 in patients treated with continuous ambulatory peritoneal dialysis

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