Nitric Oxide Inhibition Simulates the Enhancement of α1Agonist-Induced Vasoconstriction in Diabetes

Dresner, Lisa; Wang, Stewart P.; West, Michael W.; Ponomarenko, Ihor N.; Mueller, Cathy M.; Wait, Richard B.

doi:10.1006/jsre.1997.5106

Cited by 21 publications

(15 citation statements)

References 21 publications

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“…Our findings provide further evidence for this view to include the hyperresponsiveness of the renal vasculature of streptozotocin induced diabetic rats. Furthermore, Dresner et al (1997) were able to show that it was the a 1 -, but not a 2 -, adrenoceptor mediated vasoconstrictor responses that were enhanced in streptozotocin diabetic rats.…”

Section: A Armenia Et Al Renal Adrenoceptors In Diabetes and Hypertementioning

confidence: 90%

The contribution of adrenoceptor subtype(s) in the renal vasculature of diabetic spontaneously hypertensive rats

Armenia

Munavvar

Abdullah

et al. 2004

British J Pharmacology

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1 Diabetes and hypertension are both associated with an increased risk of renal disease and are associated with neuropathies, which can cause defective autonomic control of major organs including the kidney. This study aimed to examine the a 1 -adrenoceptor subtype(s) involved in mediating adrenergically induced renal vasoconstriction in a rat model of diabetes and hypertension. 2 Male spontaneously hypertensive rats (SHR), 220-280 g, were anaesthetized with sodium pentobarbitone 7-day poststreptozotocin (55 mg kg À1 i.p.) treatment. The reductions in renal blood flow (RBF) induced by increasing frequencies of electrical renal nerve stimulation (RNS), close intrarenal bolus doses of noradrenaline (NA), phenylephrine (PE) or methoxamine were determined before and after administration of nitrendipine (Nit), 5-methylurapidil (5-MeU), chloroethylclonidine (CEC) and BMY 7378. 3 In the nondiabetic SHR group, mean arterial pressure (MAP) was 14676 mmHg, RBF was 28.071.4 ml min À1 kg À1 and blood glucose was 112.374.7 mg dl À1, and in the diabetic SHR Group, MAP was 14473 mmHg, RBF 26.971.3 ml À1 min kg À1 and blood glucose 316.2710.5 mg dl À1. Nit, 5-MeU and BMY 7378 blunted all the adrenergically induced renal vasoconstrictor responses in SHR and diabetic SHR by 25-35% (all Po0.05), but in diabetic rats the responses induced by RNS and NA treated with 5-MeU were not changed. By contrast, during the administration of CEC, vasoconstrictor responses to all agonists were enhanced by 20-25% (all Po0.05) in both the SHR and diabetic SHR. 4 These findings suggest that a 1A and a 1D -adrenoceptor subtypes contribute in mediating the adrenergically induced constriction of the renal vasculature in both the SHR and diabetic SHR. There was also an indication of a greater contribution of presynaptic adrenoceptors, that is, a 1B -, and/or a 2 -subtypes.

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Section: A Armenia Et Al Renal Adrenoceptors In Diabetes and Hypertementioning

confidence: 90%

The contribution of adrenoceptor subtype(s) in the renal vasculature of diabetic spontaneously hypertensive rats

Armenia

Munavvar

Abdullah

et al. 2004

British J Pharmacology

View full text Add to dashboard Cite

show abstract

“…Mice (n = 8 -10, age 3 weeks) received 60 mg/kg (i.p.) of Streptozocin (STZ) in 10 mM, pH 4.8 citrate buffer (Dresner et al, 1997), and designated as STZ mice, or buffer only as control mice.…”

Section: Animalsmentioning

confidence: 99%

Improving glycogenesis in Streptozocin (STZ) diabetic mice after administration of green algae Chlorella

Cherng

Shih

2006

Life Sciences

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“…Mice (n = 8 À 10, age 3 weeks) received 60 mg/kg (i.p.) of Streptozocin (STZ) in 10 mM, pH 4.8 citrate buffer (Dresner et al, 1997), and designated as STZ mice, or buffer only as control mice.…”

Section: Animalsmentioning

confidence: 99%

Potential hypoglycemic effects of Chlorella in streptozotocin-induced diabetic mice

Cherng

Shih

2005

Life Sciences

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Nitric Oxide Inhibition Simulates the Enhancement of α1Agonist-Induced Vasoconstriction in Diabetes

Cited by 21 publications

References 21 publications

The contribution of adrenoceptor subtype(s) in the renal vasculature of diabetic spontaneously hypertensive rats

The contribution of adrenoceptor subtype(s) in the renal vasculature of diabetic spontaneously hypertensive rats

Improving glycogenesis in Streptozocin (STZ) diabetic mice after administration of green algae Chlorella

Potential hypoglycemic effects of Chlorella in streptozotocin-induced diabetic mice

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