Nitric oxide in patients with transitional bladder cancer

Eiján, Ana María; Piccardo, Inés; Riveros, María D.; Sandes, Eduardo Omar; Porcella, Hugo; Jasnis, María A.; Lustig, Eugenia Sacerdote de; Malagrino, H.; Pasik, Leonardo; Casabé, Alberto Ricardo

doi:10.1002/jso.10170

Cited by 28 publications

(18 citation statements)

References 27 publications

(29 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has been reported that continuous NO production may be involved in the inflammatory process associated with the appearance of many human malignancies, including bladder cancer (O’Byrne and Dalgleish 2001). Furthermore, it has been reported that NO is elevated in the urine from patients with bladder cancer (Eijan et al 2002). However, Bukan et al (2003) did not observed any significant difference in serum total nitrite levels of the patients with bladder cancer and control subjects.…”

Section: Discussionmentioning

confidence: 99%

Serum prolidase activity, oxidative stress, and nitric oxide levels in patients with bladder cancer

Geçit

Aslan

Güneş

et al. 2012

J Cancer Res Clin Oncol

View full text Add to dashboard Cite

ObjectivesProlidase is a member of the matrix metalloproteinase family. It plays a major role in collagen turnover, matrix remodeling and cell growth. Nitric oxide (NO) regulates many processes such as collagen synthesis and matrix remodeling. Thus, NO may augment angiogenesis, tumor invasion, and metastasis. The aim of this study was to investigate total antioxidant status (TAS), malondialdehyde (MDA) and NO levels in patients with bladder cancer and to determine their relationship with prolidase activity.Design and methodsThirty-five patients with bladder cancer and 32 controls were enrolled. Serum TAS, MDA, prolidase activity and NO levels were determined.ResultsSerum prolidase activity, NO levels and MDA levels were significantly higher in bladder cancer than controls (all, P < 0.05), while TAS levels were significantly lower (P < 0.05).ConclusionsOur results show that increased prolidase seems to be associated with increased NO levels and oxidative stress along with decreased antioxidant levels in bladder cancer.

show abstract

Section: Discussionmentioning

confidence: 99%

Serum prolidase activity, oxidative stress, and nitric oxide levels in patients with bladder cancer

Geçit

Aslan

Güneş

et al. 2012

J Cancer Res Clin Oncol

View full text Add to dashboard Cite

show abstract

“…Various lines of evidence reported an increased oxidative stress in patients with breast cancer [152,153]. Increased NO levels have been reported in bladder cancer patients [154]. This NO stimulates matrix metalloproteinases (MMPs), especially prolidase activity, which is involved in the terminal step of collagen degradation.…”

Section: Bladder Cancermentioning

confidence: 99%

Free Radicals: Properties, Sources, Targets, and Their Implication in Various Diseases

2014

View full text Add to dashboard Cite

Free radicals and other oxidants have gained importance in the field of biology due to their central role in various physiological conditions as well as their implication in a diverse range of diseases. The free radicals, both the reactive oxygen species (ROS) and reactive nitrogen species (RNS), are derived from both endogenous sources (mitochondria, peroxisomes, endoplasmic reticulum, phagocytic cells etc.) and exogenous sources (pollution, alcohol, tobacco smoke, heavy metals, transition metals,

show abstract

“…An inverse correlation has been defined between NOS presence and tumor differentiation in human gynecologic tumors and human colorectal carcinoma cells 11,19 . Such a correlation was not observed between urine or tumor tissue NO and iNOS expression with tumor grade or stage 13,15 , 17 . Results of the present study were also in accordance with current literature.…”

Section: Discussionmentioning

confidence: 99%

“…In many studies, the association of NO with bladder cancer has been investigated by demonstrating iNOS expression in cancer tissue immunohistochemically, but quantitative measurement of serum, urine or tissue NO has rarely been performed 15–17 . Because iNOS expression was recently shown in bladder cancer tissue, Eijan et al .…”

Section: Discussionmentioning

confidence: 99%

Can the levels of nitric oxide in the urine, serum and tumor tissue be putative markers for bladder cancer?

Kılıç¹,

Bayraktar

Beytur³

et al. 2006

Int J of Urology

View full text Add to dashboard Cite

Aim:To determine nitric oxide (NO) levels in serum, urine, tumor tissue and non-malignant adjacent tissue in bladder cancer patients compared with those in patients with a non-neoplastic genitourinary disease and to evaluate postoperative serum and urine NO change. Methods: Samples was collected in 20 cancer and 41 control patients. Griess reagent was used for NO measurements. Results: Mean age in the cancer and control groups was 64.2 ± 9.9 and 63.7 ± 8.9 years, respectively. Preoperatively, urinary infection incidence was not statistically different between groups. There were no significant differences in serum, urine and tissue NO levels in patients with and without infection in both groups. Hematuria was found to not affect urine NO level in the cancer group. Urine NO level was significantly higher than in controls preoperatively, decreased significantly following operation and remained stable after the third month. High serum NO values decreased at the early postoperative period; however, they reincreased in the long-term. No significant differences were observed in the third month in serum and urine NO levels between the patients with (no. 6) and without (no. 14) residual or relapsing tumor. No statistical difference was observed between NO levels in non-malignant adjacent and control tissues. However, tumor tissue NO level was significantly higher than those in the other two. There were no statistical differences in the first and third month serum and urine NO levels between patients who underwent bacillus Calmette-Guérin instillation therapy postoperatively and the patients who took chemotherapy or no further treatment. Conclusions: Both local and generalized host defense mechanisms seem to function in bladder cancer patients. Although further evaluation with a longer observation period and larger numbers of patients is necessary, results suggest that serum and urine NO levels are not putative and useful markers for bladder cancer.

show abstract

Nitric oxide in patients with transitional bladder cancer

Abstract: Although a wider study is necessary, our results suggest that the enhanced NO levels could perhaps be considered as a putative marker in TBC patients.

Cited by 28 publications

References 27 publications

Serum prolidase activity, oxidative stress, and nitric oxide levels in patients with bladder cancer

Serum prolidase activity, oxidative stress, and nitric oxide levels in patients with bladder cancer

Free Radicals: Properties, Sources, Targets, and Their Implication in Various Diseases

Can the levels of nitric oxide in the urine, serum and tumor tissue be putative markers for bladder cancer?

Contact Info

Product

Resources

About