Nitric oxide has no obligatory role in isoflurane late preconditioning against myocardial stunning

The role of hypoxia-inducible factor-1 and vascular endothelial growth factor in late-phase preconditioning with xenon, isoflurane and levosimendan in rat cardiomyocytes

“…We additionally found an induction of iNOS by xenon. The role of iNOS in late-phase preconditioning was previously shown to be mediated by activation through Akt during ischaemia [16], yet was absent after ISO-induced preconditioning [17], which was confirmed by our PCR results. Given this discrepancy between ischaemic-and ISO-induced preconditioning and present findings that indicate a xenon-mediated activation of iNOS, support the hypothesis that xenon-induced signalling should be considered separately from classical anaesthetic-induced preconditioning.…”