Nitric oxide as a regulatory molecule in the processing of the visual stimulus

Lima, Mônica Gomes; Maximino, Caio; Oliveira, Karen Renata Matos; Brasil, Alódia; Crespo-López, María Elena; Batista, Evander de Jesus Oliveira; Rocha, Fabiana; Picanço-Diniz, Domingos Luiz Wanderley; Herculano, Anderson Manoel

doi:10.1016/j.niox.2013.10.011

Cited by 18 publications

(7 citation statements)

References 93 publications

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“…Interestingly, nitric oxide (NO) downregulates Zeb2, and induces Zeb2-repressing microRNA, during mesoendodermal differentiation of mouse ESCs (Rosati et al, 2011). Considering the important regulatory roles of NO in the nervous system (Lima et al, 2014;Lorenc-Koci and Czarnecka, 2013;Savidge, 2014;Vincent, 2010), it is possible that NO targets Zeb2 in neurons also. In terms of other relevant studies which used ESCs as developmental models, Chng et al (2010) demonstrated that ZEB2 induces, and is required for, neuroectodermal differentiation in human ESCs, and that it represses mesoendodermal differentiation induced by activin-nodal signalling.…”

Section: Zeb2 In Neural Inductionmentioning

confidence: 99%

Zeb2: A multifunctional regulator of nervous system development

Hegarty

Sullivan

O’Keeffe

2015

Progress in Neurobiology

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Section: Zeb2 In Neural Inductionmentioning

confidence: 99%

Zeb2: A multifunctional regulator of nervous system development

Hegarty

Sullivan

O’Keeffe

2015

Progress in Neurobiology

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“…In the visual system, NO is involved in the processing of visual information from the retina to the higher visual centers. There is a comprehensive review by Lima et al discussing the role of NO in the visual system [126]. In the retinal cells, it was shown that not only NO influences the expression of AMPAR subunits, but also it was shown that AMPARs can influence the NO production.…”

Section: No and Ampars In Retina As An Example Of Mutual Interactionmentioning

confidence: 99%

“…In the retina, NOS is present in different types of cells, including the pigment epithelium [127], photoreceptors, Müller cells, horizontal, bipolar, amacrine, and ganglion cells [128]. In these cells, NO initially modulates the signal generally by altering the cGMP levels [126]. Thus, some studies demonstrated the involvement of NO through activation of the sGC-cGMP-PKG pathway, acting as a modulator of the temporal properties of the glutamate response [129,130].…”

Section: No and Ampars In Retina As An Example Of Mutual Interactionmentioning

confidence: 99%

Modulation of AMPA Receptors by Nitric Oxide in Nerve Cells

Ivanova¹,

Balaban²,

Bal³

2020

IJMS

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Nitric oxide (NO) is a gaseous molecule with a large number of functions in living tissue. In the brain, NO participates in numerous intracellular mechanisms, including synaptic plasticity and cell homeostasis. NO elicits synaptic changes both through various multi-chain cascades and through direct nitrosylation of targeted proteins. Along with the N-methyl-d-aspartate (NMDA) glutamate receptors, one of the key components in synaptic functioning are α-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors—the main target for long-term modifications of synaptic effectivity. AMPA receptors have been shown to participate in most of the functions important for neuronal activity, including memory formation. Interactions of NO and AMPA receptors were observed in important phenomena, such as glutamatergic excitotoxicity in retinal cells, synaptic plasticity, and neuropathologies. This review focuses on existing findings that concern pathways by which NO interacts with AMPA receptors, influences properties of different subunits of AMPA receptors, and regulates the receptors’ surface expression.

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“…Different retinal regions present an NO production. nNOS expression has been found in the inner retina [13]. The nNOS isoform has been located anatomically by immunohistochemistry in the mouse retina in the outer plexiform layer (OPL), in bipolar, amacrine and ganglionar somas and in cellular processes in the internal plexiform layer (IPL) [14,15,16,17].…”

Section: Nitric Oxide In the Retinamentioning

confidence: 99%

Nitrosative Stress in Retinal Pathologies: Review

et al. 2019

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Nitric oxide (NO) is a gas molecule with diverse physiological and cellular functions. In the eye, NO is used to maintain normal visual function as it is involved in photoreceptor light transduction. In addition, NO acts as a rapid vascular endothelial relaxant, is involved in the control of retinal blood flow under basal conditions and mediates the vasodilator responses of different substances such as acetylcholine, bradykinin, histamine, substance P or insulin. However, the retina is rich in polyunsaturated lipid membranes and is sensitive to the action of reactive oxygen and nitrogen species. Products generated from NO (i.e., dinitrogen trioxide (N2O3) and peroxynitrite) have great oxidative damaging effects. Oxygen and nitrogen species can react with biomolecules (lipids, proteins and DNA), potentially leading to cell death, and this is particularly important in the retina. This review focuses on the role of NO in several ocular diseases, including diabetic retinopathy, retinitis pigmentosa, glaucoma or age-related macular degeneration (AMD).

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Nitric oxide as a regulatory molecule in the processing of the visual stimulus

Cited by 18 publications

References 93 publications

Zeb2: A multifunctional regulator of nervous system development

Zeb2: A multifunctional regulator of nervous system development

Modulation of AMPA Receptors by Nitric Oxide in Nerve Cells

Nitrosative Stress in Retinal Pathologies: Review

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