Nitric oxide and tissue destruction

Kendall, H. K.; Marshall, R. I.; Bartold, P. Mark

doi:10.1034/j.1601-0825.2001.0070102.x

Cited by 39 publications

(63 citation statements)

References 75 publications

(88 reference statements)

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“…According to Batista et al (2002), the increase in the number of iNOS + cells in human PD in relation to healthy tissues, and the fact that these positive cells were predominantly PMNs, suggest that these cells, while lower in number than mononuclear cells (MNs) in studied samples, are not just innate and specific immune defense components, but also are involved in the pathogenesis of PD through NO production. Additionally, the NO-mediated cytotoxicity probably occurs in association with its capacity to activate MMPs released mainly by macrophages, PMNs and activated resident fibroblasts (Kendall et al 2001;Kroncke et al 1997). In view of this, we suggest that the exuberant presence of PMNs, in tissues affected by experimental PD, especially during initial periods, may be related to the important expression of iNOS and MMP-9 mRNA found at 3 days post induction.…”

Section: Discussionmentioning

confidence: 89%

“…Several studies have verified increased presence and activity of iNOS on PD in rats (Lohinai et al 1998;Di Paola et al 2004) and humans (Matejka et al 1998;Kendall et al 2001;Batista et al 2002), especially in macrophages, plasma cells, lymphocytes and PMNs. A suggestive increase in NO production was also detected during initial periods of experimentally-induced PD at around day 8 (Lohinai et al 1998;Di Paola et al 2004).…”

Section: Discussionmentioning

confidence: 96%

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Morphologic evaluation and expression of matrix metalloproteinases-2 and 9 and nitric oxide during experimental periodontal disease in rat

et al. 2008

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The immunopathologic and inflammatory mechanisms involved in periodontal disease (PD) include the participation of host resident, inflammatory cells and chemical mediators. Metalloproteinases (MMPs) and nitric oxide (NO) play essential role in extracellular matrix turnover of periodontal tissue destruction. In this study, by means of RT-PCR through semi-quantitative densitometric scanning methods, the expression of MMPs -2 and -9 and inducible NO synthase (iNOS) was temporally and spatially investigated during the destructive mechanisms of experimentally induced PD in rats. Samples from different periods were microscopically analyzed and compared with the contralateral side (control). Our results showed significant expression of MMP-9 and iNOS in tissues affected by PD, as compared with controls, three days after PD induction, simultaneously with the beginning of alveolar bone loss. At 7 days post induction, only the MMP-9 mRNA presented a significantly higher expression, as compared with the respective controls. Thus, in the rat ligature-induced PD, MMP-9 and iNOS might importantly participate in the early stages of the disease, including inflammatory cell migration, tissue destruction and alveolar bone resorption. Also, we may suggest that the exuberant presence of PMNs may be related to the important expression of iNOS and MMP-9 found at 3 days post induction.

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Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 96%

Morphologic evaluation and expression of matrix metalloproteinases-2 and 9 and nitric oxide during experimental periodontal disease in rat

et al. 2008

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“…Also induction of apoptosis may be seen as a response to oxidative DNA damage, this damage can occurred by ROS, and especially by nitric oxide. Both in experimental models and human samples of periodontal diseases, an increase in local NO production has been reported [143]. The induction of NO synthesis expression may also inhibit fibroblast proliferation and induce apop tosis, contributing to the imbalance of tissue destruction with tissue repair that is characteristic of periodontitis.…”

Section: Ros Mediate Damage In Inflammatory Periodontal Pathologiesmentioning

confidence: 98%

Reactive Oxygen Species and Human Inflammatory Periodontal Diseases

Çanakçı

Çiçek

Çanakçı

2005

Biochemistry (Moscow)

122

107

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Reactive oxygen species (ROS) have emerged as important signaling molecules in the regulation of various cellular processes. They can be generated by the mitochondrial electron transport chain in mitochondria and activation of polymorphonuclear leukocytes (PMN) during inflammatory conditions. Excessive generation of ROS may result in attack of and damage to most intracellular and extracellular components in a living organism. Moreover, ROS can directly induce and/or regulate apoptotic and necrotic cell death. Periodontal pathologies are inflammatory and degenerative diseases. Several forms of periodontal diseases are associated with activated PMN. Damage of tissues in inflammatory periodontal pathologies can be mediated by ROS resulting from the physiological activity of PMN during the phagocytosis of periodontopathic bacteria.

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“…The third isoform is an inducible isoenzyme (iNOS or NOS2). NOS2 is a mediator of the tumoricidal and bactericidal action of macrophages [9,[29][30][31][32][33][34][35][37][38][39].…”

Section: Introductionmentioning

confidence: 99%

“…Nitric oxide (NO) is a free radical that has been implicated in osteoclast function under normal and pathologic conditions [29]. Three different isoforms of NOS have been described: Endothelial NOS (eNOS or NOS1) and neuronal NOS (nNOS or NOS3) are called constitutive because they are essentially expressed and continuously and functionally modulated [20,[25][26][27][28][29][30][31][32][33][34][35][36]. The third isoform is an inducible isoenzyme (iNOS or NOS2).…”

Section: Introductionmentioning

confidence: 99%

Histological and immunohistochemical evaluation of the peri-implant soft tissues around machined and acid-etched titanium healing abutments: a prospective randomised study

et al. 2011

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A close spatial correlation has been described between the roughness of intraoral materials and the rate of bacterial colonisation. The aim of the present study in man was to conduct a comparative immunohistochemical evaluation of the inflammatory infiltrate, microvessel density, the nitric oxide synthases 1 and 3 and the vascular endothelial growth factor expression, the proliferative activity, and the B and T lymphocyte and histiocyte positivity in the peri-implant soft tissues around machined and acid-etched titanium healing caps. Ten patients participated in this study. The patients were enrolled consecutively. All patients received dental implants left to heal in a non-submerged mode. Healing caps were inserted in all implants. Half of the implants were supplied randomly with machined caps of titanium (control), while the other half were provided randomly with acid-etched titanium caps (test). After a 6-month healing period, a gingival biopsy was performed with a circular scalpel around the healing caps of both groups. The inflammatory infiltrate was mostly present in test specimens. Their extension was much larger than that of the control samples. A higher number of T and B lymphocytes were observed in test specimens. Higher values of microvessel density and a higher expression of vascular endothelial growth factor intensity were observed in the test samples. Furthermore, the Ki-67, NOS1 and NOS3 expression was significantly higher in the test specimens. All these results showed that the tissues around test healing caps underwent a higher rate of restorative processes, most probably correlated to the higher inflammation processes observed in these tissues.

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Nitric oxide and tissue destruction

Cited by 39 publications

References 75 publications

Morphologic evaluation and expression of matrix metalloproteinases-2 and 9 and nitric oxide during experimental periodontal disease in rat

Morphologic evaluation and expression of matrix metalloproteinases-2 and 9 and nitric oxide during experimental periodontal disease in rat

Reactive Oxygen Species and Human Inflammatory Periodontal Diseases

Histological and immunohistochemical evaluation of the peri-implant soft tissues around machined and acid-etched titanium healing abutments: a prospective randomised study

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