Nitric oxide and sleep

Gautier-Sauvigné, Sabine; Colas, Damien; Parmantier, Pierre; Clément, P.; Gharib, Abdallah; Sarda, Nicole; Cespuglio, Raymond

doi:10.1016/j.smrv.2004.07.004

Cited by 72 publications

(50 citation statements)

References 93 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Supporting evidence was obtained from previous studies showing increased free radical production and increased lipid peroxidation accompanying with lower antioxidant levels in OSAHS patients [3][4][5]. Reactive oxygen and nitrogen species are the most important free radicals causing oxidative/nitrosative stress and tissue injury related to the several diseases, which are also seen in OSAHS patients [6][7][8]. Nitric oxide (NO) is synthesized in mammalian cells from L-arginine through enzymatic reactions catalyzed by a family of NO synthases (NOS).…”

Section: Introductionsupporting

confidence: 62%

“…Nitric oxide (NO) is synthesized in mammalian cells from L-arginine through enzymatic reactions catalyzed by a family of NO synthases (NOS). Besides acting as a key vasodilator in the vascular system, it is also regulates a great variety of physiological functions including the memory process and sleep-wake cycle and inflammatory process [6,9]. Lower NO levels were shown in OSAHS patients compared with healthy controls in previous studies [10][11][12].…”

Section: Introductionmentioning

confidence: 88%

See 1 more Smart Citation

Circulating nitric oxide (NO), asymmetric dimethylarginine (ADMA), homocysteine, and oxidative status in obstructive sleep apnea–hypopnea syndrome (OSAHS)

Özkan

Fırat²,

Şimşek

et al. 2007

Sleep Breath

View full text Add to dashboard Cite

Obstructive sleep apnea-hypopnea syndrome (OSAHS) with episodic hypoxia-reoxygenation is associated with increased cardiovascular morbidity and mortality. Therefore, increased homocysteine, asymmetric dimethylarginine (ADMA), oxidative status, and decreased nitric oxide levels have been implicated as possible mechanisms for development of cardiovascular diseases. We aimed to investigate changes in the levels of these substances in patients with OSAHS in comparison with nonapneic controls. Thirty-four OSAHS patients and 15 healthy controls were included in this study. In the blood samples, oxidative status and nitric oxide levels were measured with spectrophotometric methods. Plasma ADMA and homocysteine levels were determined by using high-performance liquid chromatography with fluorescence detection. Nitric oxide levels were significantly low in OSAHS patients (p < 0.05) and correlated with mean SaO(2) (r = 0.513, p < 0.002) and lowest SaO(2) (r = 0.363, p < 0.03). Oxidative status, ADMA, and homocysteine levels were higher in OSAHS patients, but difference did not reach statistical significance. After dividing patients into moderate (AHI = 5-29) and severe (AHI > or = 30) OSAHS groups, significantly increased homocysteine levels were observed in the severe OSAHS group (p < 0.05). Nitric oxide levels negatively correlated with oxidative status in total OSAHS patients (r = -0.415, p < 0.02) and also in severe OSAHS group (r = -0.641, p < 0.007). Hyperhomocysteinemia and diminished NO production may be causal factors in endothelial dysfunction seen in OSAHS and may explain the association between OSAHS and cardiovascular diseases. These modifiable factors should be monitored in patients suspected of having OSAHS.

show abstract

Section: Introductionsupporting

confidence: 62%

Section: Introductionmentioning

confidence: 88%

Circulating nitric oxide (NO), asymmetric dimethylarginine (ADMA), homocysteine, and oxidative status in obstructive sleep apnea–hypopnea syndrome (OSAHS)

Özkan

Fırat²,

Şimşek

et al. 2007

Sleep Breath

View full text Add to dashboard Cite

show abstract

“…The NO concentrations produced by these enzymes remain relatively low as compared to the amounts produced by iNOS (rev. by Esplugues 2002;Gautier-Sauvigné et al 2005;Guix et al 2005). This suggests that low or phasic increases of NO level, produced by nNOS/ eNOS during arousal, stimulate BF neurons and facilitate processes relating with high neuronal activity, while the increase produced by iNOS, e.g., during sleep deprivation could promote sleep via inhibition of BF neurons (Kalinchuk et al 2006b).…”

Section: Discussionmentioning

confidence: 99%

Nitric oxide modulates the discharge rate of basal forebrain neurons

et al. 2008

View full text Add to dashboard Cite

show abstract

“…NO has been reported to be associated with the control of sleep wake regulation [34] as well as the regulation of striatal dopamine neurotransmission [35,36]. An association was observed between NOS1 rs7977109 and RLS in a 3-stage design study, after correction for multiple testing [20].…”

Section: Discussionmentioning

confidence: 95%

Genetic Association Study of Restless Legs Syndrome in Chinese Population

Chen¹,

Luo²,

Li³

et al. 2019

Eur Neurol

View full text Add to dashboard Cite

Backgrounds: Several recent case-control studies have suggested some candidate genes being responsible for causing the restless legs syndrome (RLS). However, the association between those genes and the risk for RLS among the Asian population has not been well investigated. Objectives: The aim of the study was to investigate the genetic risk factors of RLS among the Chinese Population. Methods: A total of 158 RLS patients and 229 controls were recruited and the diagnosis of RLS was based on the criteria of International RLS Study Group. Polymer chain reaction and sequencing were used to detect 14 single nucleotide polymorphisms (SNPs) in 9 genetic loci (heme oxygenase 1 [HMOX1], HMOX2, vitamin D3 [1, 25-dihydroxyvitamin D3] receptor gene [VDR], interleukin 17A [IL17A], IL1B, NOS1, alcohol-dehydrogenase [ADH1B], gamma-aminobutyrate acid receptors[GABRR3] and GABRA4). Results: Among 14 selected SNPs, the frequency of IL1B rs1143634C allelic variant was lower in RLS patients than that in controls. Moreover, after adjustment for age and sex, rs731236 of VDR were found associated with increased risk of RLS in the dominant model. However, none of those results survived Bonferroni correction. The effects of HMOX1 and HMOX2 gene on developing RLS were not seen after the inclusion of RLS patients with a low ferritin level. Conclusions: Our study failed to replicate the association between 9 candidate genetic loci (HMOX1, HMOX2, VDR, IL17A, IL1B, NOS1, ADH1B, GABRR3 and GABRA4) and RLS in the Chinese population.

show abstract

Nitric oxide and sleep

Cited by 72 publications

References 93 publications

Circulating nitric oxide (NO), asymmetric dimethylarginine (ADMA), homocysteine, and oxidative status in obstructive sleep apnea–hypopnea syndrome (OSAHS)

Circulating nitric oxide (NO), asymmetric dimethylarginine (ADMA), homocysteine, and oxidative status in obstructive sleep apnea–hypopnea syndrome (OSAHS)

Nitric oxide modulates the discharge rate of basal forebrain neurons

Genetic Association Study of Restless Legs Syndrome in Chinese Population

Contact Info

Product

Resources

About