Nitric oxide modulates the discharge rate of basal forebrain neurons

Kostin, Andrey; Stenberg, Dag; Kalinchuk, Anna V.; Porkka‐Heiskanen, Tarja

doi:10.1007/s00213-008-1257-x

Cited by 12 publications

(30 citation statements)

References 60 publications

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“…Although the drugs used in these studies may act in the peripheral vasculature, central effects on cholinergic DBB neurons are also possible. Actually, effective triggering of migraine-like headaches can be achieved by nitric oxide donors’ infusion, which has been shown to alter DBB cholinergic neuronal activity (Kostin et al, 2008). …”

Section: Discussionmentioning

confidence: 99%

Hypothalamic and basal ganglia projections to the posterior thalamus: Possible role in modulation of migraine headache and photophobia

et al. 2013

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Migraine attacks are typically described as unilateral, throbbing pain that is usually accompanied by nausea, vomiting, and exaggerated sensitivities to light, noise and smell. The headache phase of a migraine attack is mediated by activation of the trigeminovascular pathway; a nociceptive pathway that originates in the meninges and carries pain signals through meningeal nociceptors to the spinal trigeminal nucleus and from there to the cortex through relay neurons in the thalamus. Recent studies in our lab have identified a population of trigeminovascular neurons in the posterior (Po) and lateral posterior (LP) thalamic nuclei that may be involved in the perception of whole-body allodynia (abnormal skin sensitivity) and photophobia (abnormal sensitivity to light) during migraine. The purpose of the current study was to identify sub-cortical areas that are in position to directly regulate the activity of these thalamic trigeminovascular neurons. Such process begins with anatomical mapping of neuronal projections to the posterior thalamus of the rat by performing discrete injections of the retrograde tracer Fluorogold into the Po/LP region. Such injections yielded retrogradely labeled neurons in the nucleus of the diagonal band of Broca, the dopaminergic cells group A11/A13, the ventromedial and ventral tuberomamillary nuclei of the hypothalamus. We also found that some of these neurons contain acetylcholine, dopamine, cholecystokinin and histamine, respectively. Accordingly, we speculate that these forebrain/hypothalamic projections to Po and LP may play a role in those migraine attacks triggered by disrupted sleep, skipping meals and emotional reactions.

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Section: Discussionmentioning

confidence: 99%

Hypothalamic and basal ganglia projections to the posterior thalamus: Possible role in modulation of migraine headache and photophobia

et al. 2013

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“…This response was more prominent in stimulus-on than in stimulus-off neurons and the inhibitory effect is partly mediated via purinergic or metabotropic glutamate receptors (22,23,32). Although the rationale for attenuated urinary sodium excretion observed after icv insulin administration in animals simultaneously treated with L-NAME remains unknown, speculatively, it is tempting to suggest that perhaps one of the efferent signals triggered by insulin in the CNS may be nitrergic in nature.…”

Section: Discussionmentioning

confidence: 85%

“…These effects might be partially due to a direct inhibition of growth factors by S-nitrosylation (21). Also, recent studies have demonstrated that NO modulates the synaptic activity and neuronal discharge rates in a dose-dependent manner (22,23). However, there is little information on the neural mechanisms that mediate the effects of icv insulin administration on renal sodium handling in rats.…”

Section: Introductionmentioning

confidence: 94%

Consequences of cerebroventricular insulin injection on renal sodium handling in rats: effect of inhibition of central nitric oxide synthase

Oliveira¹,

Michelotto²,

Zapparoli³

et al. 2009

Braz J Med Biol Res

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“…The details of the surgical and recording procedures have been described earlier (Kostin et al, 2008). Briefly, eleven rats were anesthetized by urethane (i.p., 1.5g/kg) and placed in a stereotaxic apparatus.…”

Section: Methodsmentioning

confidence: 99%

“…NO levels are higher in the cortex during spontaneous arousal and in the basal forebrain (BF) during sleep deprivation (SD) (Burlet and Cespuglio, 1997, Cespuglio et al, 2004, Kalinchuk et al, 2006a). Recent electrophysiological studies show that locally increased NO concentration predominantly exerts inhibitory effects on the discharge of BF neurons (Kostin et al, 2008, Kostin et al, 2009). Such inhibition is proposed to induce the compensatory recovery sleep after prolonged waking, since blockade of NO synthesis in the BF impairs recovery sleep subsequent to SD (Kalinchuk et al, 2006a, Kalinchuk et al, 2006b).…”

Section: Introductionmentioning

confidence: 99%

Nitric oxide production in the perifornical-lateral hypothalamic area and its influences on the modulation of perifornical-lateral hypothalamic area neurons

et al. 2011

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The perifornical-lateral hypothalamic area (PF-LHA) is a major wake-promoting structure. It predominantly contains neurons that are active during behavioral and cortical activation. PF-LHA stimulation produces arousal and PF-LHA lesions produce somnolence. Nitric oxide (NO) is a gaseous neurotransmitter that has been implicated in the regulation of multiple pathological and physiological processes including the regulation of sleep. NO levels are higher in the cortex and in the basal forebrain (BF) during arousal. In this study we determined whether NO levels increase in the PF-LHA during prolonged arousal and whether increased NO modulates the discharge activity of PF-LHA neurons. Experiments were conducted during lights-on phase between 8.00 – 20.00h (lights-on at 8.00h). First, we quantified levels of NO metabolites, NO2− and NO3− (collectively called NOx−) in the microdialysis dialysates collected from the PF-LHA during baseline (undisturbed rats), 6h of sleep deprivation (SD), and recovery after SD. We further determined the effects of a NO donor, NOC-18, on the discharge activity of PF-LHA neurons in urethane-anesthetized rats. Overall, SD significantly affected NOx− production in the PF-LHA (one way repeated measures ANOVA, F=7.827, p=0.004). The levels of NOx− increased progressively in animals that were subjected to prolonged arousal as compared to the undisturbed predominantly sleeping animals and decreased during the recovery period. Local application of NOC-18 significantly suppressed the discharge of PF-LHA neurons including a majority of stimulus-on neurons or neurons exhibiting activation during EEG desynchronization. The findings of this study suggest that in the PF-LHA, NO production is elevated during prolonged waking and that NO exerts predominantly inhibitory effects on PF-LHA neurons, especially on those neurons that are active during cortical activation. These findings are consistent with a hypothesis that NO in the PF-LHA plays a role in sleep regulation by inhibiting its neurons.

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Nitric oxide modulates the discharge rate of basal forebrain neurons

Abstract: NO modulates the BF neuronal discharge rates in a dose-dependent manner. The inhibitory effect is partly mediated via adenosine A1 receptors.

Cited by 12 publications

References 60 publications

Hypothalamic and basal ganglia projections to the posterior thalamus: Possible role in modulation of migraine headache and photophobia

Hypothalamic and basal ganglia projections to the posterior thalamus: Possible role in modulation of migraine headache and photophobia

Consequences of cerebroventricular insulin injection on renal sodium handling in rats: effect of inhibition of central nitric oxide synthase

Nitric oxide production in the perifornical-lateral hypothalamic area and its influences on the modulation of perifornical-lateral hypothalamic area neurons

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