Nitric oxide and antioxidant enzyme levels in blood of respiratory distress syndrome – Egyptian preterms and their mothers

El-Masry, Hosny M. A.; Nasr, Abdurrahman A.; Kabeer, Ashraf M. Al; Amin, Hiral; Eldeeb, Hussein M.

doi:10.3109/14767058.2014.900039

Cited by 5 publications

(5 citation statements)

References 20 publications

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“…have been inconclusive regarding the SOD antioxidant activity. Some authors have observed a decrease of levels or activities of SOD in preterm neonates compared with controls (36,39). However, other studies reported an increase (40) or the absence of significant differences in SOD between premature and term newborns (41,42).…”

Section: Discussionmentioning

confidence: 98%

“…Although it was reported that GPx activity increased in preterm infants vs. term infants (42), many other studies have evidenced a deficiency in the glutathione system in preterm newborns (51). Clifford and Lovina (52) and other authors have shown lower GPx activities in preterm infants relative to term neonates, especially in those preterm infants with OxS-related neonatal morbidities (36,39). Ochoa et al (53) also observed lower cytosolic GPx activity, associated with higher levels of hydroperoxides in erythrocyte membranes, among a group of preterm infants a 72 h after birth.…”

Section: Discussionmentioning

confidence: 99%

“…Thus, lower values of these enzymes are expected in preterm infants compared to term infants. There are multiple useful studies evaluating compounds of antioxidant systems in the cord blood samples of preterm infants (12,38,39). However, little information is available on the levels of enzymatic antioxidant activities in preterm children beyond birth and their possible roles in developing metabolic problems.…”

Section: Discussionmentioning

confidence: 99%

“…As indicated above, CAT is an important cytoprotective enzyme that converts hydrogen peroxide to water and oxygen (8). Some studies comparing the antioxidant systems in preterm and term neonates have shown reduced catalase values in infants born prematurely, especially in those developing neonatal complications (38,39). Nevertheless, other researchers did not find significant relationships between prematurity and catalase enzyme activity at birth (41,42).…”

Section: Discussionmentioning

confidence: 99%

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Impaired Antioxidant Defence Status Is Associated With Metabolic-Inflammatory Risk Factors in Preterm Children With Extrauterine Growth Restriction: The BIORICA Cohort Study

et al. 2021

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Introduction: An impaired antioxidant status has been described during foetal growth restriction (FGR). Similarly, the antioxidant defence system can be compromised in preterm children with extrauterine growth restriction (EUGR). The aim of this prospective study was to evaluate the antioxidant status in prepubertal children with a history of prematurity without FGR, with and without EUGR, compared to a healthy group.Methods: In total, 211 children were recruited and classified into three groups: 38 with a history of prematurity and EUGR; 50 with a history of prematurity and adequate extrauterine growth (AEUG); and 123 control children born at term. Catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx) and glutathione reductase (GR) activities were assessed in lysed erythrocytes with spectrophotometric methods. Plasma levels of the antioxidants α-tocopherol, retinol and β-carotene were determined through solvent extraction and ultra-high-pressure liquid chromatography coupled to mass spectrometry.Results: Children with the antecedent of EUGR and prematurity had lower CAT activity than the other two groups and lower GPx activity than the control children. Lower SOD, GPx and GR activities were observed in the AEUG group compared to the controls. However, higher concentrations of α-tocopherol and β-carotene were found in the EUGR group compared to the other groups; retinol levels were also higher in EUGR than in AEUG children. In EUGR and AEUG children, enzymatic antioxidant activities and plasma antioxidants were associated with metabolic syndrome components and pro-inflammatory biomarkers.Conclusions: This study reveals, for the first time, that the EUGR condition and prematurity appear to be linked to an impairment of the antioxidant defence status, which might condition an increased risk of adverse metabolic outcomes later in life.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Impaired Antioxidant Defence Status Is Associated With Metabolic-Inflammatory Risk Factors in Preterm Children With Extrauterine Growth Restriction: The BIORICA Cohort Study

et al. 2021

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“…Additionally, there are considerable variations in the contribution of vasoactive substances to endothelium-dependent relaxations in different tissues-it appears that nitric oxide (NO) is the principal vasodilator in conduit arteries, whereas other mediators, such as endothelialderived hyperpolarising factors (EDHF), make a significant contribution at the level of the resistance arteries [47,48]. Despite this clear role for other mediators, NO is the most extensively studied vasodilator in the preterm newborn [49][50][51][52][53], partly due to its therapeutic use for the treatment of persistent pulmonary hypertension of the newborn.…”

Section: Vasodilatationmentioning

confidence: 99%

Microcirculation of the Newborn

Wright¹,

Dyson²

2016

Microcirculation Revisited - From Molecules to Clinical Practice

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Appropriate regulation of microvascular blood flow in the neonate is crucial for cardiorespiratory stability and survival in the period immediately following birth. Inappropriate microvascular dilatation in the first few days of extrauterine life is associated with poor outcomes in preterm neonates. Male very preterm neonates (≤28 weeks completed gestation) have significantly higher flows than females of the same gestational age. This is of clinical importance as preterm males are twice as likely to die as females. Very little is known about the mechanisms underlying microvascular tone regulation in the perinatal period. Previous studies suggest a role for the gasotransmitters nitric oxide and carbon monoxide; however, differences in levels of these molecules do not account for all the variation observed, suggesting another player. In this chapter, the role of the third gasotransmitter-hydrogen sulphide-as a potential mediator of microvascular (dys)function in the preterm is explored.

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Factors relating caesarean section to persistent pulmonary hypertension of the newborn

2017

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Nitric oxide and antioxidant enzyme levels in blood of respiratory distress syndrome – Egyptian preterms and their mothers

Abstract: The existence of oxygen metabolites and lipid peroxidation was significantly more obvious in RDS preterms and in their mothers than those without.

Cited by 5 publications

References 20 publications

Impaired Antioxidant Defence Status Is Associated With Metabolic-Inflammatory Risk Factors in Preterm Children With Extrauterine Growth Restriction: The BIORICA Cohort Study

Impaired Antioxidant Defence Status Is Associated With Metabolic-Inflammatory Risk Factors in Preterm Children With Extrauterine Growth Restriction: The BIORICA Cohort Study

Microcirculation of the Newborn

Factors relating caesarean section to persistent pulmonary hypertension of the newborn

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