Nitric oxide: an antiparasitic molecule of invertebrates

Rivero, Ana

doi:10.1016/j.pt.2006.02.014

Cited by 183 publications

(154 citation statements)

References 69 publications

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“…NO is an important molecule because it participates in several physiological and pathological processes, including immune response to microbes and parasites, in insects (47,48). To examine the potential involvement of NO in the differential survival of background D. melanogaster strains to bacterial infections, we estimated the amount of the NO oxidation product nitrite.…”

Section: Discussionmentioning

confidence: 99%

Nitric Oxide Levels Regulate the Immune Response of Drosophila melanogaster Reference Laboratory Strains to Bacterial Infections

Eleftherianos

Spivack

et al. 2014

Infect Immun

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Studies on the innate immune response against microbial infections in Drosophila melanogaster involve mutant strains and their reference strains that act as experimental controls. We used five standard D. melanogaster laboratory reference strains (Oregon R, w1118, Canton-S, Cinnabar Brown, and Yellow White [YW]) and investigated their response against two pathogenic bacteria (Photorhabdus luminescens and Enterococcus faecalis) and two nonpathogenic bacteria (Escherichia coli and Micrococcus luteus). We detected high sensitivity among YW flies to bacterial infections and increased bacterial growth compared to the other strains. We also found variation in the transcription of certain antimicrobial peptide genes among strains, with Oregon and YW infected flies showing the highest and lowest gene transcription levels in most cases. We show that Oregon and w1118 flies possess more circulating hemocytes and higher levels of phenoloxidase activity than the other strains upon infection with the nonpathogenic bacteria. We further observed reduced fat accumulation in YW flies infected with the pathogenic bacteria, which suggests a possible decline in physiological condition. Finally, we found that nitrite levels are significantly lower in infected and uninfected YW flies compared to w1118 flies and that nitric oxide synthase mutant flies in YW background are more susceptible to bacterial infection compared to mutants in w1118 background. Therefore, increased sensitivity of YW flies to bacterial infections can be partly attributed to lower levels of nitric oxide. Such studies will significantly contribute toward a better understanding of the genetic variation between D. melanogaster reference strains.

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Section: Discussionmentioning

confidence: 99%

Nitric Oxide Levels Regulate the Immune Response of Drosophila melanogaster Reference Laboratory Strains to Bacterial Infections

Eleftherianos

Spivack

et al. 2014

Infect Immun

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“…NO has been shown to have a crucial role in immunoregulation and it is implicated in host nonspecific defense in a variety of infections such as malaria, toxoplasmosis, leishmaniosis, trypanosomosis and schistosomosis. 76 Recently, we suggested a selective pressure by endemic malaria exerted on NOS1 (CA)n e29 alleles that correlated to NO overproduction in Corsica. 77 In this paper, we showed that alleles previously correlated with NO overproduction (alleles 16 and 17) are more represented in a sample of b 0 39 carriers than in control samples, suggesting a selective effect of malaria on alleles that correlated with NO overproduction.…”

Section: Discussionmentioning

confidence: 99%

Selective neutrality analysis of 17 STRs in Mediterranean populations

et al. 2010

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Detection of genes that have been targeted by natural selection is a powerful tool for predicting regions of the genome potentially linked with diseases and of interest in the field of genetic epidemiology. In recent years, several methods to detect patterns of natural selection have been developed. In general, these tests are based on different assumptions and parameters; hence, the detection of outlier loci with more than one statistical approach simultaneously will support the candidate status of a particular locus. In this study, we evaluated the presence of patterns of positive selection in 17 short tandem repeat loci genotyped in six different human populations from the Mediterranean area, for a total of 429 individuals. To identify patterns of selective pressure, we applied three different neutrality tests on the basis of different models, performing pairwise comparisons between populations. Results show the presence of one marker, a (CA)n repeat located in exon 29 of the NOS1 gene, which seems significant in the three different tests in two pairwise comparisons: Sicily vs Morocco and Balearic Islands vs Morocco. This suggests that this locus and its genome localization are candidates for further studies to investigate selective pressure, as well as for association studies.

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“…A ubiquitous member of the immune and nervous systems, NO is a potent molecule with deleterious properties towards pathogens ranging from viruses to metazoans (Rivero, 2006). In Drosophila, NO may be implicated in the destruction of parasites through various pathways (Carton et al, 2009).…”

Section: No and Other Free Radicalsmentioning

confidence: 99%

Parasite-induced alterations of sensorimotor pathways in gammarids: collateral damage of neuroinflammation?

Helluy

2013

Journal of Experimental Biology

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Nitric oxide: an antiparasitic molecule of invertebrates

Cited by 183 publications

References 69 publications

Nitric Oxide Levels Regulate the Immune Response of Drosophila melanogaster Reference Laboratory Strains to Bacterial Infections

Nitric Oxide Levels Regulate the Immune Response of Drosophila melanogaster Reference Laboratory Strains to Bacterial Infections

Selective neutrality analysis of 17 STRs in Mediterranean populations

Parasite-induced alterations of sensorimotor pathways in gammarids: collateral damage of neuroinflammation?

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