Nitrergic Inhibitory Component of Rectal Response to Pelvic Nerve Stimulation

Nitric Oxide Synthase Expression in Rat Anorectal Tissue after Sacral Neuromodulation

“…There is evidence that nitric oxide (NO) is an important inhibitory neurotransmitter in the internal anal sphincter (IAS) and the circular and longitudinal muscle layers of the rectum [7,8]. This simple molecule is a short-lived free radical, which has a number of physiologic functions including nonadrenergic-noncolinergic neurotransmission, and has emerged as a potent biological mediator and neurotransmitter in the central and peripheral nervous system [9].…”