Nitrate Supplementation Enhances the Contractile Properties of Human Skeletal Muscle

Haider, Georg; Folland, Jonathan P.

doi:10.1249/mss.0000000000000351

Cited by 141 publications

(205 citation statements)

References 31 publications

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“…These effects, which were reported in predominantly type II muscle, were accompanied by an increased muscle force production. Subsequent studies have confirmed the beneficial effect of NO 3 − on force production in humans (Haider and Folland 2014;Coggan et al 2015). It is therefore possible that elevated type II muscle Ca 2+ handling and muscle contractile function may have further contributed to the improved 1500 m performance observed in the present investigation.…”

Section: Effects Of Brj On 1500 M Tt Performancesupporting

confidence: 70%

Dietary nitrate supplementation enhances short but not longer duration running time-trial performance

et al. 2017

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TT performance between conditions (2643.1 ± 324. 1 vs. 2649.9 ± 319.8 s, P > 0.05). Conclusion Acute BRJ supplementation significantly enhanced 1500 m, but not 10,000 m TT performance. These findings suggest that BRJ might be ergogenic during shorter distance TTs which allow for a high work rate, but not during longer distance TTs, completed at a lower work rate. ) supplementation on physiological functioning and exercise performance in trained runners/triathletes conducting short and longer-distance treadmill running time-trials (TT). Method Eight trained male runners or triathletes completed four exercise performance tests comprising a 10 min warm up followed by either a 1500 or 10,000 m treadmill TT. Exercise performance tests were preceded 3 h before the exercise by supplementation with either 140 ml concentrated nitrate-rich (~12.5 mmol nitrate) (BRJ) or nitratedeplete (~0.01 mmol nitrate) (PLA) beetroot juice. Results BRJ supplementation significantly elevated plasma [NO 2 − ] (P < 0.05). Resting blood pressure and exercise V O 2 were not significantly different between BRJ and PLA (P > 0.05). However, post-exercise blood [lactate] was significantly greater in BRJ following the 1500 m TT (6.6 ± 1.2 vs. 6.1 ± 1.5 mM; P < 0.05), but not significantly different between conditions in the 10,000 m TT (P > 0.05). Performance in the 1500 m TT was significantly faster in BRJ vs. PLA (319.6 ± 36.2 vs. 325.7 ± 38.8 s; P < 0.05). Conversely, there was no significant difference in 10,000 m Communicated by Keywords

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Section: Effects Of Brj On 1500 M Tt Performancesupporting

confidence: 70%

Dietary nitrate supplementation enhances short but not longer duration running time-trial performance

et al. 2017

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“…These include, but are not restricted to: lower blood pressure [1][2][3], reduced O2 consumption (V O2) during steady-state exercise [4][5][6], attenuated muscle metabolic perturbations [7,8], and enhanced muscle force production [9,10]. These effects are not directly attributable to the nitrate anion, which is relatively inert [11].…”

Section: Introductionmentioning

confidence: 99%

Dietary nitrate supplementation enhances high-intensity running performance in moderate normobaric hypoxia, independent of aerobic fitness

et al. 2016

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Nitrate-rich beetroot juice (BRJ) increases plasma nitrite concentration, lowers the oxygen cost (V O2) of steady-state exercise and improves exercise performance in sedentary and moderately-trained, but rarely in well-trained individuals exercising at sea-level. BRJ supplementation may be more effective in a hypoxic environment, where the reduction of nitrite into nitric oxide (NO) is potentiated, such that well-trained and less well-trained individuals may derive a similar ergogenic effect.We conducted a randomised, counterbalanced, double-blind placebo controlled trial to determine the effects of BRJ on treadmill running performance in moderate normobaric hypoxia (equivalent to 2500 m altitude) in participants with a range of aerobic fitness levels. Twelve healthy males (V O2max ranging from 47.1 -76.8 ml·kg -1 ·min -1 ) ingested 138 ml concentrated BRJ (~ 15.2 mmol nitrate) or a nitrate-deplete placebo (PLA) (~ 0.2 mmol nitrate). Three hours later, participants completed steady-state moderate intensity running, and a 1500 m time-trial (TT) in a normobaric hypoxic chamber (FIO2 ~15 %). Plasma nitrite concentration was significantly greater following BRJ versus PLA 1 hour post supplementation, and remained higher in BRJ throughout the testing session (p < 0.01). Average V O2 was significantly lower (BRJ: 18.4 ± 2.0, PLA: 20.4 ± 12.6 ml·kg -1 ·min -1 ; p = 0.002), whilst arterial oxygen saturation (SaO2) was significantly greater (BRJ: 88.4 ± 2.7, PLA: 86.5 ± 3.3 %; p < 0.001) following BRJ. BRJ improved TT performance in all 12 participants by an average of 3.2 % (BRJ: 331.1 ± 45.3 vs. PL: 341.9 ± 46.1 s; p < 0.001). There was no apparent relationship between aerobic fitness and the improvement in performance following BRJ (r 2 = 0.05, p > 0.05). These findings suggests that a high nitrate dose in the form of a BRJ supplement may improve running performance in individuals with a range of aerobic fitness levels conducting moderate and high-intensity exercise in a normobaric hypoxic environment.

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“…25 The burden of hypertension is particularly important in developing countries where the 26 limited access to adequate treatments and health care and the concomitant occurrence of 27 communicable diseases and nutritional deficiencies increase the risk for disability and 28 cardiovascular fatal events [2].…”

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confidence: 99%

“…Eight studies had a cross-over study design [7,16, 26]and the remaining five studies adopted a parallel study design [17][18][19]27,28]. Ten studies 129 used a double-blind placebo controlled design [7,16,18,[22][23][24][25][26][27][28]. The trials were conducted characteristics of the studies included in the analysis are presented in Table S1 of the online 133 supplementary material.…”

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Medium-term effects of dietary nitrate supplementation on systolic and diastolic blood pressure in adults

Ashor

Lara

Siervo

2017

Journal of Hypertension

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1Objectives: Dietary nitrate supplementation has been shown to lower blood pressure (BP) 2 particularly in short-term clinical trials. Whether these effects are sustained in the long-term 3 remains to be established. The objective was to conduct a meta-analysis of randomised 4 controlled trials that examined whether dietary nitrate supplementation for more than one 5 week has beneficial effects on systolic and diastolic BP. control groups. Random-effects models were used to calculate the pooled BP effect sizes.

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Nitrate Supplementation Enhances the Contractile Properties of Human Skeletal Muscle

Cited by 141 publications

References 31 publications

Dietary nitrate supplementation enhances short but not longer duration running time-trial performance

Dietary nitrate supplementation enhances short but not longer duration running time-trial performance

Dietary nitrate supplementation enhances high-intensity running performance in moderate normobaric hypoxia, independent of aerobic fitness

Medium-term effects of dietary nitrate supplementation on systolic and diastolic blood pressure in adults

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