NIR-Triggered Sequentially Responsive Nanocarriers Amplified Cascade Synergistic Effect of Chemo-Photodynamic Therapy with Inspired Antitumor Immunity

Fan, Jian; Qi, Jing; Zhu, Minxia; Liu, Di; You, Yuchan; Gao, Shu; Du, Yan; Wang, Jun; Yu, Hui; Sun, Mingchen; Xu, Xiaoling; Shen, Qiying; Ying, Xiaoying; Ji, Jiansong; Du, Yong‐Zhong

doi:10.1021/acsami.0c07503

Cited by 41 publications

(39 citation statements)

References 49 publications

(80 reference statements)

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“…However, both chemotherapeutic drugs and A2AR antagonists have limited tumor-targeting ability after intravenous administration, which often induces undesirable adverse effects and unsatisfactory efficacy. Smart nanoparticle drug delivery system is an effective way to alter biodistribution of drugs and achieve spatiotemporally controlled drug release, which is beneficial for improving treatment safety and efficacy 8,[21][22][23] . Significantly, thermal-sensitive drug delivery system has attracted much attention; hyperthermia stimuli at the tumor site can accelerate the drug release from nanoparticles to achieve precise therapy, and on the other hand, hyperthermia itself can also suppress tumor growth 24,25 .…”

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confidence: 99%

Synergistic effect of tumor chemo-immunotherapy induced by leukocyte-hitchhiking thermal-sensitive micelles

Fan

You

et al. 2021

Nat Commun

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Some specific chemotherapeutic drugs are able to enhance tumor immunogenicity and facilitate antitumor immunity by inducing immunogenic cell death (ICD). However, tumor immunosuppression induced by the adenosine pathway hampers this effect. In this study, E-selectin-modified thermal-sensitive micelles are designed to co-deliver a chemotherapeutic drug (doxorubicin, DOX) and an A2A adenosine receptor antagonist (SCH 58261), which simultaneously exhibit chemo-immunotherapeutic effects when applied with microwave irradiation. After intravenous injection, the fabricated micelles effectively adhere to the surface of leukocytes in peripheral blood mediated by E-selectin, and thereby hitchhiking with leukocytes to achieve a higher accumulation at the tumor site. Further, local microwave irradiation is applied to induce hyperthermia and accelerates the release rate of drugs from micelles. Rapidly released DOX induces tumor ICD and elicits tumor-specific immunity, while SCH 58261 alleviates immunosuppression caused by the adenosine pathway, further enhancing DOX-induced antitumor immunity. In conclusion, this study presents a strategy to increase the tumor accumulation of drugs by hitchhiking with leukocytes, and the synergistic strategy of chemo-immunotherapy not only effectively arrested primary tumor growth, but also exhibited superior effects in terms of antimetastasis, antirecurrence and antirechallenge.

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Synergistic effect of tumor chemo-immunotherapy induced by leukocyte-hitchhiking thermal-sensitive micelles

Fan

You

et al. 2021

Nat Commun

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“…Results also indicated that chemo-PDT treatment was effective in inhibiting tumor metastasis in lungs with an increased proportion of CD4 + , CD8 + T lymphocytes in a 4T1 murine model. 45 …”

Section: Combination Of Pdt With Icd-based Therapymentioning

confidence: 99%

Nanomaterials-Based Photodynamic Therapy with Combined Treatment Improves Antitumor Efficacy Through Boosting Immunogenic Cell Death

Fan¹,

Liu²,

Xu³

et al. 2021

IJN

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Benefiting from the rapid development of nanotechnology, photodynamic therapy (PDT) is arising as a novel non-invasive clinical treatment for specific cancers, which exerts direct efficacy in destroying primary tumors by generating excessive cytotoxic reactive oxygen species (ROS). Notably, PDT-induced cell death is related to T cell-mediated antitumor immune responses through induction of immunogenic cell death (ICD). However, ICD elicited via PDT is not strong enough and is limited by immunosuppressive tumor microenvironment (ITM). Therefore, it is necessary to improve PDT efficacy through enhancing ICD with the combination of synergistic tumor therapies. Herein, the recent progress of nanomaterials-based PDT combined with chemotherapy, photothermal therapy, radiotherapy, and immunotherapy, employing ICD-boosted treatments is reviewed. An outlook about the future application in clinics of nanomaterials-based PDT strategies is also mentioned.

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“…The ICD process mainly has adenosine triphosphate (ATP) secretion, heat shock protein (HSP)-antigen peptide complex, calreticulin (CRT) surface exposure, and release of high migration protein B1 (HMGB1) (Garg et al, 2013 ). Jin et al loaded chemotherapy DOX and photosensitive rose-bengal (RB) into ROS response micelles based on UCNPs (β-NaYF 4 :Yb,Er), and constructed the treatment nanoplatform (Jin et al, 2020 ). The ROS response micelles were constructed from biocompatible sialic acid (SA), PEG, thioketone (TK), and poly(lactic-co-glycolic acid) (PLGA).…”

Section: The Corpration Of Ucnps and Immunotherapymentioning

confidence: 99%

Section: The Corpration Of Ucnps and Immunotherapymentioning

confidence: 99%

Recent Advances on Rare Earth Upconversion Nanomaterials for Combined Tumor Near-Infrared Photoimmunotherapy

et al. 2020

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Cancer has been threatening the safety of human life. In order to treat cancer, many methods have been developed to treat tumor, such as traditional therapies like surgery, chemotherapy, radiotherapy, as well as new strategies like photodynamic therapy, photothermal therapy, sonodynamic therapy, and other emerging therapies. Although there are so many ways to treat tumors, these methods all face the dilemma that they are incapable to cope with metastasis and recurrence of tumors. The emergence of immunotherapy has given the hope to conquer the challenge. Immunotherapy is to use the body's own immune system to stimulate and maintain a systemic immune response to form immunological memory, resist the metastasis and recurrence of tumors. At the same time, immunotherapy can combine with other treatments to exhibit excellent antitumor effects. Upconversion nanoparticles (UCNPs) can convert near-infrared (NIR) light into ultraviolet and visible light, thus have good performance in bioimaging and NIR triggered phototherapy. In this review paper, we summarize the design, fabrication, and application of UCNPs-based NIR photoimmunotherapy for combined cancer treatment, as well as put forward the prospect of future development.

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NIR-Triggered Sequentially Responsive Nanocarriers Amplified Cascade Synergistic Effect of Chemo-Photodynamic Therapy with Inspired Antitumor Immunity

Cited by 41 publications

References 49 publications

Synergistic effect of tumor chemo-immunotherapy induced by leukocyte-hitchhiking thermal-sensitive micelles

Synergistic effect of tumor chemo-immunotherapy induced by leukocyte-hitchhiking thermal-sensitive micelles

Nanomaterials-Based Photodynamic Therapy with Combined Treatment Improves Antitumor Efficacy Through Boosting Immunogenic Cell Death

Recent Advances on Rare Earth Upconversion Nanomaterials for Combined Tumor Near-Infrared Photoimmunotherapy

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