NIR triggered liposome gold nanoparticles entrapping curcumin as in situ adjuvant for photothermal treatment of skin cancer

Singh, Surya Prakash; Alvi, Syed Baseeruddin; Pemmaraju, Deepak Bharadwaj; Singh, Anula Divyash; Manda, Sasidhar Venkata; Srivastava, Rohit; Rengan, Aravind Kumar

doi:10.1016/j.ijbiomac.2017.11.163

Cited by 91 publications

(52 citation statements)

References 31 publications

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“…In many of these examples, the bioconjugation strategies are designed to impart controlled drug release by any of a number of external stimuli. Various nanoparticles are often incorporated with the liposomes in order to achieve this responsiveness [31][32][33][34][35][36][37][38][39][40][41]. While some of the examples discussed here may include this stimuli-triggered response, our main focus in this review is a discussion of the bioconjugation strategies used to load/append drugs to the liposome.…”

Section: Strategies For Drug Incorporation and Liposome Bioconjugatiomentioning

confidence: 99%

Recent Progress in Bioconjugation Strategies for Liposome-Mediated Drug Delivery

et al. 2020

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In nanoparticle (NP)-mediated drug delivery, liposomes are the most widely used drug carrier, and the only NP system currently approved by the FDA for clinical use, owing to their advantageous physicochemical properties and excellent biocompatibility. Recent advances in liposome technology have been focused on bioconjugation strategies to improve drug loading, targeting, and overall efficacy. In this review, we highlight recent literature reports (covering the last five years) focused on bioconjugation strategies for the enhancement of liposome-mediated drug delivery. These advances encompass the improvement of drug loading/incorporation and the specific targeting of liposomes to the site of interest/drug action. We conclude with a section highlighting the role of bioconjugation strategies in liposome systems currently being evaluated for clinical use and a forward-looking discussion of the field of liposomal drug delivery.

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Section: Strategies For Drug Incorporation and Liposome Bioconjugatiomentioning

confidence: 99%

Recent Progress in Bioconjugation Strategies for Liposome-Mediated Drug Delivery

et al. 2020

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“…The cytotoxic effects in murine melanoma cells increased more than 80% after laser irradiation for 5 min and caused irreversible cell damage. The addition of curcumin showed improved cytotoxicity in cancer cells [301].…”

Section: Laser Irradiation Therapymentioning

confidence: 96%

Nanotechnology approaches in the current therapy of skin cancer

Borgheti-Cardoso

Viegas

Silvestrini

et al. 2020

Advanced Drug Delivery Reviews

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Skin cancer is a high burden disease with a high impact on global health. Conventional therapies have several drawbacks; thus, the development of effective therapies is required. In this context, nanotechnology approaches are an attractive strategy for cancer therapy because they enable the efficient delivery of drugs and other bioactive molecules to target tissues with low toxic effects. In this review, nanotechnological tools for skin cancer will be summarized and discussed. First, pathology and conventional therapies will be presented, followed by the challenges of skin cancer therapy. Then, the main features of developing efficient nanosystems will be discussed, and next, the most commonly used nanoparticles (NPs) described in the literature for skin cancer therapy will be presented. Subsequently, the use of NPs to deliver chemotherapeutics, immune and vaccine molecules and nucleic acids will be reviewed and discussed as will the combination of physical methods and NPs. Finally, multifunctional delivery systems to codeliver anticancer therapeutic agents containing or not surface functionalization will be summarized.

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“…It is evident that the employment of AuNPs has several advantages since the treatment can be efficiently targeted to specific tissues and tumors in deep tissues and may be combined with drug therapy using AuNPs as DDSs. Several NIR-responsive AuNP-based nanosystems were developed to deliver Cur or Res to cancer cells for the treatment of malignant melanoma [ 97 , 98 , 108 , 109 , 110 , 111 , 112 , 113 ] and breast and cervical cancer [ 105 , 107 ] ( Table 3 and Table 4 ).…”

Section: Gold-based Hybrid Nanosystemsmentioning

confidence: 99%

Natural Product-Based Hybrids as Potential Candidates for the Treatment of Cancer: Focus on Curcumin and Resveratrol

et al. 2021

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One of the main current strategies for cancer treatment is represented by combination chemotherapy. More recently, this strategy shifted to the “hybrid strategy”, namely the designing of a new molecular entity containing two or more biologically active molecules and having superior features compared with the individual components. Moreover, the term “hybrid” has further extended to innovative drug delivery systems based on biocompatible nanomaterials and able to deliver one or more drugs to specific tissues or cells. At the same time, there is an increased interest in plant-derived polyphenols used as antitumoral drugs. The present review reports the most recent and intriguing research advances in the development of hybrids based on the polyphenols curcumin and resveratrol, which are known to act as multifunctional agents. We focused on two issues that are particularly interesting for the innovative chemical strategy involved in their development. On one hand, the pharmacophoric groups of these compounds have been used for the synthesis of new hybrid molecules. On the other hand, these polyphenols have been introduced into hybrid nanomaterials based on gold nanoparticles, which have many potential applications for both drug delivery and theranostics in chemotherapy.

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NIR triggered liposome gold nanoparticles entrapping curcumin as in situ adjuvant for photothermal treatment of skin cancer

Cited by 91 publications

References 31 publications

Recent Progress in Bioconjugation Strategies for Liposome-Mediated Drug Delivery

Recent Progress in Bioconjugation Strategies for Liposome-Mediated Drug Delivery

Nanotechnology approaches in the current therapy of skin cancer

Natural Product-Based Hybrids as Potential Candidates for the Treatment of Cancer: Focus on Curcumin and Resveratrol

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